The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Stimulus-Responsive “Smart” Hydrogels as Novel Drug Delivery Systems
Abstract
Recently, there has been a great deal of research activity in the development of stimulus-responsive polymeric hydrogels. These hydrogels are responsive to external or internal stimuli and the response can be observed through abrupt changes in the physical nature of the network. This property can be favorable in many drug delivery applications. The external stimuli can be temperature, pH, ionic strength, ultrasonic sound, electric current, etc. A majority of the literature related to the development of stimulus-responsive drug delivery systems deals with temperature-sensitive poly(N-isopropyl acrylamide) (pNIPAAm) and its various derivatives. However, acrylic-based pH-sensitive systems with weakly acidic/basic functional groups have also been widely studied. Quite recently, glucose-sensitive hydrogels that are responsive to glucose concentration have been developed to monitor the release of insulin. The present article provides a brief introduction and recent developments in the area of stimulus-responsive hydrogels, particularly those that respond to temperature and pH, and their applications in drug delivery.
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Cites
Kohori, F., Sakai, K., Aoyagi, T., Yokoyama, M., Sakurai, Y., & Okano, T. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00023-6 · Cited by 273
Cited by
Hydrogels in controlled release formulations: Network design and mathematical modeling
Lin, C.-C., & Metters, A. T. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.004 · Cited by 1,768
Responsive polymers in controlled drug delivery
Bajpai, A. K., Shukla, S. K., Bhanu, S., & Kankane, S. (2008) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2008.07.005 · Cited by 1,391
Thermo-responsive polymers and their application as smart biomaterials
Kim, Y.-J., & Matsunaga, Y. T. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb00157f · Cited by 568
El-Husseiny, H. M., Mady, E. A., Hamabe, L., Abugomaa, A., Shimada, K., Yoshida, T., Tanaka, T., Yokoi, A., Elbadawy, M., & Tanaka, R. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2021.100186 · Cited by 533
Release mechanisms for polyelectrolyte capsules
De Geest, B. G., Sanders, N. N., Sukhorukov, G. B., Demeester, J., & De Smedt, S. C. (2007) · Chem. Soc. Rev. · doi:10.1039/b600460c · Cited by 462
Metadata
- Authors
- Soppimath, K. S., Aminabhavi, T. M., Dave, A. M., Kumbar, S. G., & Rudzinski, W. E.
- Venue
- Drug Development and Industrial Pharmacy
- Publisher
- Informa UK Limited
- Published
- 2002-01
- Volume
- 28
- Issue
- 8
- Pages
- 957-974
- ISSN
- 0363-9045 (ISSN-L)
- 1520-5762
- OpenAlex
- W2043860148
- Cited by
- 389
- References
- 1
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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