The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Cytochrome P450: What Have We Learned and What Are the Future Issues?
Abstract
The cytochrome P450 (P450) field came out of interest in the metabolism of drugs, carcinogens, and steroids, which remain major focal points. Over the years we have come to understand the P450 system components, the multiplicity of P450s, and many aspects of the regulation of the genes and also the catalytic mechanism. Many crystal structures are now becoming available. The significance of P450 in in vivo metabolism is appreciated, particularly in the context of pharmacogenetics. Current scientific issues involve posttranslational modification, gene regulation, component interactions, structures of P450 complexed with ligands, details of high-valent oxygen chemistry, the nature and influence of rate-limiting steps, greater details about some reaction steps, cooperativity, and the relevance of P450 variations to cancer risk. Some emerging research areas involve new methods of analysis of ligand interactions, roles of conformational changes linked to individual reaction steps, functions of orphan P450s, "molecular breeding" of new P450 functions and enhanced activity, and the utilization of P450s in chemical synthesis.
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Cites
The Aryl Hydrocarbon Receptor Complex
Hankinson, O. (1995) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.001515 · Cited by 1,649 · cited 1×
“Knowledge of the roles of these receptors and the AhR/ARNT system (Hankinson, 1995) has led to the use of simplified reporter systems to use in screening for P450 induction with new drugs, which has relevance to predictions of drug interactions and, in some cases, tumorigenicity.”
MethodCongenital adrenal hyperplasia
Speiser, P. W., & White, P. C. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021561 · Cited by 1,405
Poland, A., Glover, E., & Kende, A. S. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33205-2 · Cited by 1,370
Mammalian Microsomal Cytochrome P450 Monooxygenase
Williams, P. A., Cosme, J., Sridhar, V., Johnson, E. F., & McRee, D. E. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80408-6 · Cited by 696
Chung, B. C., Matteson, K. J., Voutilainen, R., Mohandas, T. K., & Miller, W. L. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.23.8962 · Cited by 354
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Self-citationShimozawa, O., Sakaguchi, M., Ogawa, H., Harada, N., Mihara, K., & Omura, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36937-6 · Cited by 91
Cited by
Cytochromes P450 as versatile biocatalysts
Bernhardt, R. (2006) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2006.01.026 · Cited by 886
Cytochrome P450s and other enzymes in drug metabolism and toxicity
Guengerich, F. P. (2006) · The AAPS Journal · doi:10.1208/aapsj080112 · Cited by 624
Targeting Aldehyde Dehydrogenase 2: New Therapeutic Opportunities
Chen, C.-H., Ferreira, J. C. B., Gross, E. R., & Mochly-Rosen, D. (2014) · Physiological Reviews · doi:10.1152/physrev.00017.2013 · Cited by 614
Huang, N., Pandey, A. V., Agrawal, V., Reardon, W., Lapunzina, P. D., Mowat, D., Jabs, E. W., Vliet, G. V., Sack, J., Flück, C. E., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/429417 · Cited by 336
Huang, N., Agrawal, V., Giacomini, K. M., & Miller, W. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711621105 · Cited by 198
Metadata
- Authors
- Peter Guengerich, F.
- Venue
- Drug Metabolism Reviews
- Publisher
- Informa UK Limited
- Published
- 2004-01
- Volume
- 36
- Issue
- 2
- Pages
- 159-197
- ISSN
- 0360-2532 (ISSN-L)
- 1097-9883
- OpenAlex
- W2155529149
- Cited by
- 193
- References
- 7
- FWCI
- 14.45
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
