The DOI matches its Crossref record; 327 of the 327 references it cites were found in a registry or an index.
Targeting Aldehyde Dehydrogenase 2: New Therapeutic Opportunities
Open accessAbstract
A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a subject of recent interest, as its role in detoxifying aldehydes that accumulate through metabolism and to which we are exposed from the environment has been elucidated. Although the human genome has 19 ALDH genes, one ALDH emerges as a particularly important enzyme in a variety of human pathologies. This ALDH, ALDH2, is located in the mitochondrial matrix with much known about its role in ethanol metabolism. Less known is a new body of research to be discussed in this review, suggesting that ALDH2 dysfunction may contribute to a variety of human diseases including cardiovascular diseases, diabetes, neurodegenerative diseases, stroke, and cancer. Recent studies suggest that ALDH2 dysfunction is also associated with Fanconi anemia, pain, osteoporosis, and the process of aging. Furthermore, an ALDH2 inactivating mutation (termed ALDH2*2) is the most common single point mutation in humans, and epidemiological studies suggest a correlation between this inactivating mutation and increased propensity for common human pathologies. These data together with studies in animal models and the use of new pharmacological tools that activate ALDH2 depict a new picture related to ALDH2 as a critical health-promoting enzyme.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
3 retracted
Doser, T. A., Turdi, S., Thomas, D. P., Epstein, P. N., Li, S.-Y., & Ren, J. (2009) · Circulation · doi:10.1161/circulationaha.108.823799 · Cited by 196
RetractedHwang, E., & Kim, G. (2006) · Toxicology · doi:10.1016/j.tox.2006.10.013 · Cited by 149
RetractedZhang, Y., Babcock, S. A., Hu, N., Maris, J. R., Wang, H., & Ren, J. T. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-40 · Cited by 130
RetractedGlobal Cancer Statistics, 2002
Parkin, D. M., Bray, F., Ferlay, J., & Pisani, P. (2005) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.55.2.74 · Cited by 18,196
A simple technique for quantitation of low levels of DNA damage in individual cells
Singh, N. P., McCoy, M. T., Tice, R. R., & Schneider, E. L. (1988) · Experimental Cell Research · doi:10.1016/0014-4827(88)90265-0 · Cited by 10,828
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
Zuckerman, A. J. (1995) · Journal of Clinical Pathology · doi:10.1136/jcp.48.7.691-a · Cited by 8,728
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
Esterbauer, H., Schaur, R. J., & Zollner, H. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90192-6 · Cited by 6,672
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Liu, C.-C., Kanekiyo, T., Xu, H., & Bu, G. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.263 · Cited by 3,459
Cited by
Millwood, I. Y., Walters, R. G., Mei, X. W., Guo, Y., Yang, L., Bian, Z., Bennett, D. A., Chen, Y., Dong, C., Hu, R., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(18)31772-0 · Cited by 514
Wang, S., Wang, L., Qin, X., Turdi, S., Sun, D., Culver, B., Reiter, R. J., Wang, X., Zhou, H., & Ren, J. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0171-5 · Cited by 135
Disulfiram Treatment Normalizes Body Weight in Obese Mice
Bernier, M., Mitchell, S. J., Wahl, D., Diaz, A., Singh, A., Seo, W., Wang, M., Ali, A., Kaiser, T., Price, N. L., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.019 · Cited by 85
Huang, P.-H., Hu, C.-C., Chien, C.-H., Chen, L.-W., Chien, R.-N., Lin, Y.-S., Chao, M., Lin, C.-L., & Yeh, C.-T. (2019) · Journal of Cancer · doi:10.7150/jca.33221 · Cited by 15
Ferreira, I., Machado de Oliveira, R., Carvalho, A. S., Teshima, A., Beck, H. C., Matthiesen, R., Costa-Silva, B., & Macedo, M. P. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00353 · Cited by 9
Metadata
- Authors
- Chen, C.-H., Ferreira, J. C. B., Gross, E. R., & Mochly-Rosen, D.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2014-01
- Volume
- 94
- Issue
- 1
- Pages
- 1-34
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2110549318
- Cited by
- 614
- References
- 327
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Targeting Aldehyde Dehydrogenase 2: New Therapeutic Opportunities. https://app.cochat.ai/papers/10.1152/physrev.00017.2013
- The paper
- Chen, C.-H., Ferreira, J. C. B., Gross, E. R., & Mochly-Rosen, D. (2014). Targeting Aldehyde Dehydrogenase 2: New Therapeutic Opportunities. Physiological Reviews. https://doi.org/10.1152/physrev.00017.2013
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
