Three-Dimensional Magnetic Resonance Coronary Angiography Using a New Blood Pool Contrast Agent: Initial Experience
Abstract
Objective The aim of this feasibility study was to assess the effect of a new blood pool contrast agent on magnetic resonance coronary angiography (MRCA) in patients suspected of having coronary artery disease. Methods Nine patients referred for diagnostic x-ray coronary angiography in the evaluation of chest pain underwent MRCA using a thin-slab three-dimensional (3D) breath-hold segmented gradient echo technique at 1.5 T before and after intravenous administration of feruglose, a new blood pool contrast agent. Results A total of 36 coronary arteries, including 15 stenoses were evaluated. Overall agreement of visually assessed stenoses > 50% was 86%. The mean signal-to-noise ratio in the left anterior descending artery (LAD) did not change significantly after contrast administration, a relative improvement of 1.2 +/- 0.4 (p = 0.1), whereas the mean contrast-to-noise ratio of blood to myocardium improved by 3 +/- 2 (p = 0.01). Conclusion A thin-slab 3D breath-hold scan combined with feruglose allows rapid localization and coverage of the proximal coronary arteries.
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Feruglose has been proven suitable for visualization of proximal coronary arteries with thin slab 3D breath hold scans.
“Together with thin slab 3D breath hold scans, feruglose has been proven to be suitable for the visualization of proximal coronary arteries [185].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [185]
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Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
Klein, C., Schalla, S., Schnackenburg, B., Bornstedt, A., Hoffmann, V., Fleck, E., & Nagel, E. (2003) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.10317 · Cited by 29 · see citing works
Self-citation
- Authors
- Bedaux, W. L. F., Hofman, M. B. M., Wielopolski, P. A., de Cock, C. C., Hoffmann, V., Oudkerk, M., de Feyter, P. J., & van Rossum, A. C.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- Erasmus University Rotterdam (NL)
- Venue
- Journal of Cardiovascular Magnetic Resonance
- Publisher
- Elsevier BV
- Published
- 2002
- Volume
- 4
- Issue
- 2
- Pages
- 273-282
- ISSN
- 1097-6647 (ISSN-L)
- 1532-429X
- OpenAlex
- W2143612860
- Cited by
- 14
- References
- 0
- Citations by year
- 2023: 1 · 2019: 1
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cardiovascular Magnetic Resonance (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Coronary Artery Anomalies
- Keywords
- coronary magnetic resonance angiography, blood pool contrast agent, coronary artery disease, coronary artery stenosis, signal-to-noise ratio, contrast-to-noise ratio, left anterior descending artery, diagnostic accuracy
- MeSH terms
- Aged, Contrast Media, Coronary Artery Disease, Coronary Vessels, Feasibility Studies, Female, Humans, Image Enhancement, Iron, Male, Middle Aged, Oxides, Magnetic Resonance Angiography, Imaging, Three-Dimensional
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