Improvement of image quality of non-invasive coronary artery imaging with magnetic resonance by the use of the intravascular contrast agent Clariscan™ (NC100150 injection) in patients with coronary artery disease
Open accessAbstract
PURPOSE: To assess the feasibility of Clariscan, an intravascular contrast agent, for free breathing, navigator assisted, high resolution, three-dimensional-magnetic resonance coronary angiography (MRCA) in patients, as extracellular contrast agents are unfavorable for the improvement of image quality. MATERIALS AND METHODS: MRCA was performed in 10 patients with known coronary artery disease (CAD) with (1-5 mg Fe/kg body weight) and without contrast agent. RESULTS: Compared to unenhanced images, Clariscan did not improve signal-to-noise (SNR) or contrast-to-noise ratios (CNR) compared to fat or myocardium in the proximal parts of the coronary arteries. However, when analyzing the peripheral parts (>4 cm from origin), CNR(fat) and CNR(myo) improved up to a factor of 1.81 and 5.85, respectively, at a dose of 3 mg Fe/kg body weight, while SNR did not reach statistical significance. The visible length of the coronary arteries was improved from 49 +/- 18 mm to 73 +/- 33 mm. The proximal diameter was reduced from 3.6 +/- 0.8mm to 3.2 +/- 0.8 mm, representing more closely the diameter of 3.1 +/- 0.7 mm measured by quantitative coronary angiography. Of 11 significant stenoses (>50%), eight were identified in the enhanced compared to six in the unenhanced images. CONCLUSION: The use of Clariscan at a dose of 2-3 mg Fe/kg body weight improves image quality of three-dimensional-MRCA, especially in the peripheral segments, and, thus, the diagnostic accuracy for the detection of CAD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Coronary Magnetic Resonance Angiography for the Detection of Coronary Stenoses
Kim, W. Y., Danias, P. G., Stuber, M., Flamm, S. D., Plein, S., Nagel, E. C., Langerak, S. E., Weber, O. M., Pedersen, E. M., Schmidt, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010866 · Cited by 901 · see citing works
Self-citationGadolinium-enhanced MR aortography.
Prince, M. R. (1994) · Radiology · doi:10.1148/radiology.191.1.8134563 · Cited by 896 · see citing works
A Preliminary Report Comparing Magnetic Resonance Coronary Angiography with Conventional Angiography
Manning, W. J., Li, W., & Edelman, R. R. (1993) · New England Journal of Medicine · doi:10.1056/nejm199303253281202 · Cited by 547 · see citing works
gadolinium-enchanced MR aortography.
Kumar, P. (1994) · Radiology · Cited by 495 · see citing works
Improved Coronary Artery Definition With T2-Weighted, Free-Breathing, Three-Dimensional Coronary MRA
Botnar, R. M., Stuber, M., Danias, P. G., et al. (1999) · Circulation · doi:10.1161/01.cir.99.24.3139 · Cited by 426 · see citing works
Wang, Y., Rossman, P. J., Grimm, R. C., Riederer, S. J., & Ehman, R. L. (1996) · Radiology · doi:10.1148/radiology.198.1.8539406 · Cited by 385 · see citing works
Li, D., Paschal, C. B., Haacke, E. M., et al. (1993) · Radiology · doi:10.1148/radiology.187.2.8475281 · Cited by 227 · see citing works
Two-dimensional coronary MR angiography: analysis of initial clinical results.
Duerinckx, A. J., & Urman, M. K. (1994) · Radiology · doi:10.1148/radiology.193.3.7972815 · Cited by 226 · see citing works
Post, J. C., van Rossum, A. C., Hofman, M. B. M., Valk, J., & Visser, C. A. (1996) · American Journal of Roentgenology · doi:10.2214/ajr.166.6.8633453 · Cited by 176 · see citing works
Magnetic resonance imaging of coronary arteries: technique and preliminary results.
Pennell, D. J., Keegan, J., Firmin, D. N., Gatehouse, P. D., Underwood, S. R., & Longmore, D. B. (1993) · Heart · doi:10.1136/hrt.70.4.315 · Cited by 170 · see citing works
Coronary arteries: breath-hold, gadolinium-enhanced, three-dimensional MR angiography.
Goldfarb, J. W., & Edelman, R. R. (1998) · Radiology · doi:10.1148/radiology.206.3.9494509 · Cited by 161 · see citing works
MRI of coronary arteries: 2D breath-hold vs 3D respiratory-gated acquisition.
Hofman, M. B., Paschal, C. B., Li, D., et al. (1995) · PubMed · Cited by 115 · see citing works
Woodard, P. K., Li, D., Haacke, E. M., et al. (1998) · American Journal of Roentgenology · doi:10.2214/ajr.170.4.9530027 · Cited by 94 · see citing works
&NA; (1995) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199501000-00011 · Cited by 94 · see citing works
Classification of human liposarcoma and lipoma using ex vivo proton NMR spectroscopy
Millis, K. K., Weybright, P., Campbell, N., Fletcher, J. A., Fletcher, C. D. �., Cory, D. G., & Singer, S. (1999) · Magnetic Resonance in Medicine · doi:10.1002/(sici)1522-2594(199902)41:2 · Cited by 92 · see citing works
Motion‐adapted gating based on k‐space weighting for reduction of respiratory motion artifacts
Weiger, M., Börnert, P., Proksa, R., et al. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910380223 · Cited by 79 · see citing works
Li, D., Zheng, J., & Weinmann, H. (2001) · Radiology · doi:10.1148/radiology.218.3.r01mr03670 · Cited by 72 · see citing works
Two-dimensional coronary MRA: limitations and artifacts
Duerinckx, A. J., Atkinson, D. P., Mintorovitch, J., et al. (1996) · European Radiology · doi:10.1007/bf00180601 · Cited by 60 · see citing works
Edelman, R. R., Manning, W. J., Pearlman, J. D., et al. (1993) · Radiology · doi:10.1148/radiology.187.3.8497620 · Cited by 53 · see citing works
In vivo diffusion tensor imaging of rat spinal cord with echo planar imaging
Fenyes, D. A., & Narayana, P. A. (1999) · Magnetic Resonance in Medicine · doi:10.1002/(sici)1522-2594(199908)42:2 · Cited by 53 · see citing works
Sakuma, H., Caputo, G. R., Steffens, J.-C., et al. (1994) · American Journal of Roentgenology · doi:10.2214/ajr.163.3.8079838 · Cited by 51 · see citing works
Taupitz, M., Schnorr, J., Wagner, S., et al. (2001) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1279 · Cited by 43 · see citing works
NMR angiography of coronary vessels with 2‐D planar image scanning
Cho, Z. H., Mun, C. W., & Friedenberg, R. M. (1991) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910200114 · Cited by 42 · see citing works
Achenbach, S. S., Kessler, W., Moshage, W. E. L., et al. (1997) · Coronary Artery Disease · doi:10.1097/00019501-199707000-00006 · Cited by 32 · see citing works
Bedaux, W. L. F., Hofman, M. B. M., Wielopolski, P. A., de Cock, C. C., Hoffmann, V., Oudkerk, M., de Feyter, P. J., & van Rossum, A. C. (2002) · Journal of Cardiovascular Magnetic Resonance · doi:10.1081/jcmr-120003953 · Cited by 14 · see citing works
Self-citationSpatial regularization of flow patterns in magnetic resonance velocity mapping
Herment, A., Mousseaux, É., Cesare, A. D., Jolivet, O., Dumée, P., Todd-Pokropek, A. E., & Bittoun, J. (1999) · Journal of Magnetic Resonance Imaging · doi:10.1002/(sici)1522-2586(199911)10:5 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- Nagel E, Bornstedt A, Schnackenburg B, Hug J, Oswald H, Fleck E. Optimization of realtime adaptive navigator correction for 3D-mag- netic resonance coronary angiography. Magn Reson Med 1999;42: 408 -411.
- Wagenseil JE, Johansson LOM, Lorenz CH. Characterisation of T1 relaxation and blood-myocardial contrast enhancement of NC100150 injection in cardiac MRI. J Magn Reson Imag 1999;10: 784 -789.
- Hofman MB, Henson RE, Kova ´cs SJ, et al. Blood pool agent strongly improves 3D magnetic resonance coronary angiography using an inversion pre-pulse. Magn Reson Med 1999;41:360 -367.
- Stuber M, Botnar RM, Danias PG, et al. Contrast agent-enhanced, free breathing, three-dimensional coronary magnetic resonance angiography. J Magn Reson Imag 1999;10:790 -799.
Cited by
Sorted by citations
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
Superparamagnetic iron oxide nanoparticles: from preparations to in vivo MRI applications
Qiao, R., Yang, C., & Gao, M. (2009) · Journal of Materials Chemistry · doi:10.1039/b902394a · Cited by 685 · see citing works
Coronary CT versus MR angiography: the role of MR angiography
Sakuma, H. (2011) · Radiology · doi:10.1148/radiol.10100116 · Cited by 73 · see citing works
da Luz, P. L., Bertini, P. J., & Favarato, D. (2005) · Clinics · doi:10.1590/s1807-59322005000500011 · Cited by 13 · see citing works
- Authors
- Klein, C., Schalla, S., Schnackenburg, B., Bornstedt, A., Hoffmann, V., Fleck, E., & Nagel, E.
- Affiliations
- Deutsches Herzzentrum der Charité (DE)
- Philips (Germany) (DE)
- Corresponding author
- Klein, Christoph
- Venue
- Journal of Magnetic Resonance Imaging
- Publisher
- Wiley
- Published
- 2003-05-19
- Volume
- 17
- Issue
- 6
- Pages
- 656-662
- ISSN
- 1053-1807 (ISSN-L)
- 1522-2586
- OpenAlex
- W1999903528
- Cited by
- 29
- References
- 26
- Citations by year
- 2023: 2 · 2022: 1 · 2019: 2 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Magnetic Resonance Imaging (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Coronary Artery Anomalies
- Keywords
- intravascular contrast agents, coronary magnetic resonance angiography, coronary artery disease, image quality, contrast-to-noise ratio, signal-to-noise ratio, free breathing, coronary stenosis detection, iron-based contrast agents
- MeSH terms
- Analysis of Variance, Contrast Media, Coronary Artery Disease, Coronary Vessels, Dextrans, Feasibility Studies, Female, Humans, Image Enhancement, Iron, Magnetic Resonance Imaging, Male, Middle Aged, Oxides, Coronary Angiography, Magnetic Resonance Angiography, Imaging, Three-Dimensional, Ferrosoferric Oxide, Magnetite Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
