An environmentally friendly, low cost, one-pot synthesis of artemisitene
Abstract
An environmentally friendly, one-pot synthesis of artemisitene from artemisinin is described.
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Artemisitene can be obtained readily by chemical transformations of artemisinin, and a partial synthesis of artemisitene from artemisinic acid (473) has been reported.
“although artemisitene can be obtained readily by chemical transformations of artemisinin [165,213,241,242]; and a partial synthesis of artemisitene from artemisinic acid (473) has also been reported [243].”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [241]
Cites
Qinghaosu (Artemisinin): an Antimalarial Drug from China
Klayman, D. L. (1985) · Science · doi:10.1126/science.3887571 · Cited by 2,186 · see citing works
Artemisitene, a New Sesquiterpene Lactone Endoperoxide fromArtemisia annua
Acton, N., & Klayman, D. L. (1985) · Planta Medica · doi:10.1055/s-2007-969543 · Cited by 100 · see citing works
Paitayatat, S., Tarnchompoo, B., Thebtaranonth, Y., & Yuthavong, Y. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm960767v · Cited by 99 · see citing works
White, N. J. (1994) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(94)90459-6 · Cited by 97 · see citing works
Ekthawatchai, S., Kamchonwongpaisan, S., Kongsaeree, P., Tarnchompoo, B., Thebtaranonth, Y., & Yuthavong, Y. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm0103007 · Cited by 80 · see citing works
Overview of clinical studies on artemisinin derivatives in Thailand
Looareesuwan, S. (1994) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(94)90462-6 · Cited by 68 · see citing works
Conversion of artemisinin to artemisitene
El-Feraly, F. S., Ayalp, A., Al-Yahya, M. A., McPhail, D. R., & McPhail, A. T. (1990) · Journal of Natural Products · doi:10.1021/np50067a008 · Cited by 40 · see citing works
Methyl 2-pyridinesulfinate. A convenient reagent for sulfinylation-dehydrosulfinylation
Trost, B. M., & Parquette, J. R. (1993) · The Journal of Organic Chemistry · doi:10.1021/jo00058a048 · Cited by 34 · see citing works
Roush, W. R., & Spada, A. P. (1983) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)94511-8 · Cited by 31 · see citing works
Acid catalyzed michael additions to artemisitene
Ma, J., Weiss, E., Kyle, D. E., & Ziffer, H. (2000) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(00)00297-3 · Cited by 23 · see citing works
Michael addition of artemisitene
Liao, X., Han, J., & Li, Y. (2001) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)00310-0 · Cited by 23 · see citing works
Partial Syntheses of Methyl Dehydrojasmonate and Tuberolactone
Dubs, P., & Stüssi, R. (1978) · Helvetica Chimica Acta · doi:10.1002/hlca.19780610308 · Cited by 23 · see citing works
Total synthesis of the macrocyclic spermidine alkaloids (±)-lunarine and (±)-lunaridine
Nagao, Y., Takao, S., Miyasaka, T., & Fujita, E. (1981) · Journal of the Chemical Society Chemical Communications · doi:10.1039/c39810000286 · Cited by 21 · see citing works
Kurzer, F. (2003) · Organic Syntheses · doi:10.1002/0471264180.os034.31 · Cited by 2 · see citing works
TROST, H. M., & Parquette, J. R. (1993) · ChemInform · doi:10.1002/chin.199328164 · Cited by 1 · see citing works
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The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363 · see citing works
Artemisone—A Highly Active Antimalarial Drug of the Artemisinin Class
Haynes, R. K., Fugmann, B., Stetter, J., Rieckmann, K. H., Heilmann, H., Chan, H., Cheung, M., Lam, W. W. ‐., Wong, H. N., Croft, S. L., et al. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200503071 · Cited by 262 · see citing works
Artemisone—A Highly Active Antimalarial Drug of the Artemisinin Class
Haynes, R. K., Fugmann, B., Stetter, J., Rieckmann, K. H., Heilmann, H., Chan, H., Cheung, M., Lam, W. W. ‐., Wong, H. N., Croft, S. L., et al. (2006) · Angewandte Chemie · doi:10.1002/ange.200503071 · Cited by 31 · see citing works
Chemical transformations of artemisinin
Семаков, А. В., Afanasyeva, S. V., & Pukhov, S. A. (2025) · Russian Chemical Bulletin · doi:10.1007/s11172-024-4651-6 · Cited by 2 · see citing works
Bicyclic 6-6 Systems: Four Heteroatoms 1:3
Groundwater, P. W., Anderson, R. J., & Nyerges, M. (2008) · Elsevier eBooks · doi:10.1016/b978-008044992-0.00917-2 · Cited by 2 · see citing works
An Environmentally Friendly, Low Cost, One‐Pot Synthesis of Artemisitene.
Ekthawatchai, S., Lertvorachon, J., Meepowpan, P., Thongpanchang, T., Thebtaranonth, Y., & Yuthavong, Y. (2003) · ChemInform · doi:10.1002/chin.200338157
- Authors
- Ekthawatchai, S., Lertvorachon, J., Meepowpan, P., Thongpanchang, T., Thebtaranonth, Y., & Yuthavong, Y.
- Affiliations
- Mahidol University (TH)
- National Center for Genetic Engineering and Biotechnology (TH)
- Corresponding author
- Thongpanchang, Tienthong
- Venue
- Synthetic Communications
- Publisher
- Informa UK Limited
- Published
- 2003-06
- Volume
- 33
- Issue
- 11
- Pages
- 1855-1860
- ISSN
- 0039-7911 (ISSN-L)
- 1532-2432
- OpenAlex
- W2149745169
- Cited by
- 6
- References
- 15
- Citations by year
- 2025: 1
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Synthetic Communications (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Physical Sciences › Chemistry › Organic Chemistry › Organic Chemistry Synthesis Methods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biological Activity of Diterpenoids and Biflavonoids
- Keywords
- artemisinin, one-pot synthesis, green chemistry, low-cost synthesis, sesquiterpene synthesis, sesquiterpene lactones
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