The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization.
Open accessAbstract
In situ hybridization is used to survey the tissue-specific and developmental expression of the cloned mouse gene Sparc, coding for a protein homologous to the bovine Ca++-binding protein, osteonectin. High levels of SPARC RNA are found in osteoblasts and odontoblasts. In addition, high grain counts are associated with a variety of other cell types in the embryo and newborn mouse, including parietal endoderm, deciduum, whisker follicles (connective tissue sheath), peripheral nerve trunk, skin (dermis), and stomach (submucosa). Spatially restricted but high levels of SPARC mRNA are also seen in the adult adrenal glands, testis, and ovary. This pattern of differential gene expression demands a reassessment of the function originally proposed for osteonectin, and predicts a much wider role for the protein in a variety of biological processes.
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Cites
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Self-citationDetection of mRNAs in sea urchin embryos by in situ hybridization using asymmetric RNA probes
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Osteonectin, a bone-specific protein linking mineral to collagen
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Cited by
Role of transforming growth factor-beta in the development of the mouse embryo.
Heine, U., Munoz, E. F., Flanders, K. C., Ellingsworth, L. R., Lam, H. Y., Thompson, N. L., Roberts, A. B., & Sporn, M. B. (1987) · The Journal of cell biology · doi:10.1083/jcb.105.6.2861 · Cited by 745
SPARC, a matricellular protein: at the crossroads of cell–matrix communication
Brekken, R. A., & Sage, E. H. (2001) · Matrix Biology · doi:10.1016/s0945-053x(00)00133-5 · Cited by 585
Raines, E. W., Lane, T. F., Iruela-Arispe, M. L., Ross, R., & Sage, E. H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.4.1281 · Cited by 362
In vitro differentiation of embryonic stem cells into mineralized osteoblasts
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SPARC/osteonectin in mineralized tissue
Rosset, E. M., & Bradshaw, A. D. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.02.001 · Cited by 320
Metadata
- Authors
- Holland, P. W., Harper, S. J., McVey, J. H., & Hogan, B. L.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1987-07-01
- Volume
- 105
- Issue
- 1
- Pages
- 473-482
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2077637821
- Cited by
- 296
- References
- 23
- FWCI
- 22.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Holland, P. W., Harper, S. J., McVey, J. H., & Hogan, B. L. (1987). In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization. The Journal of cell biology. https://doi.org/10.1083/jcb.105.1.473
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
