The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
SPARC/osteonectin in mineralized tissue
Open accessAbstract
Secreted protein acidic and rich in cysteine (SPARC/osteonectin/BM40) is one of the most abundant non-collagenous protein expressed in mineralized tissues. This review will focus on elucidating functional roles of SPARC in bone formation building upon results from non-mineralized cells and tissues, the phenotype of SPARC-null bones, and recent discoveries of human diseases with either dysregulated expression of SPARC or mutations in the gene encoding SPARC that give rise to bone pathologies. The capacity of SPARC to influence pathways involved in extracellular matrix assembly such as procollagen processing and collagen fibril formation as well as the capacity to influence osteoblast differentiation and osteoclast activity will be addressed. In addition, the potential for SPARC to regulate cross-linking of extracellular matrix proteins by members of the transglutaminase family of enzymes is explored. Elucidating defined biological functions of SPARC in terms of bone formation and turnover are critical. Further insight into specific cellular mechanisms involved in the formation and homeostasis of mineralized tissues will lead to a better understanding of disease progression.
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Osteonectin, a bone-specific protein linking mineral to collagen
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Self-citationSPARC, a matricellular protein: at the crossroads of cell–matrix communication
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CRTAP Is Required for Prolyl 3- Hydroxylation and Mutations Cause Recessive Osteogenesis Imperfecta
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Revisiting the matricellular concept
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Osteopenia and decreased bone formation in osteonectin-deficient mice
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New Insights into Monogenic Causes of Osteoporosis
Mäkitie, R. E., Costantini, A., Kämpe, A., Alm, J. J., & Mäkitie, O. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00070 · Cited by 108
An integrated multi-omics analysis reveals osteokines involved in global regulation
Liang, W., Wei, T., Hu, L., Chen, M., Tong, L., Zhou, W., Duan, X., Zhao, X., Zhou, W., Jiang, Q., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.03.006 · Cited by 67
Human cells with osteogenic potential in bone tissue research
Dvorakova, J., Wiesnerova, L., Chocholata, P., Kulda, V., Landsmann, L., Cedikova, M., Kripnerova, M., Eberlova, L., & Babuska, V. (2023) · BioMedical Engineering OnLine · doi:10.1186/s12938-023-01096-w · Cited by 58
Metadata
- Authors
- Rosset, E. M., & Bradshaw, A. D.
- Venue
- Matrix Biology
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 52-54
- Pages
- 78-87
- ISSN
- 0945-053X (ISSN-L)
- OpenAlex
- W2288411839
- Cited by
- 320
- References
- 48
- FWCI
- 18.36
- Type
- journal article
- Language
- en
- Open access
- green
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