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Cartilage contains mixed fibrils of collagen types II, IX, and XI.
Open accessAbstract
The distribution of collagen XI in fibril fragments from 17-d chick embryo sternal cartilage was determined by immunoelectron microscopy using specific polyclonal antibodies. The protein was distributed throughout the fibril fragments but was antigenically masked due to the tight packing of collagen molecules and could be identified only at sites where the fibril structure was partially disrupted. Collagens II and IX were also distributed uniformly along fibrils but, in contrast to collagen XI, were accessible to the antibodies in intact fibrils. Therefore, cartilage fibrils are heterotypically assembled from collagens II, IX, and XI. This implies that collagen XI is an integral component of the cartilage fibrillar network and homogeneously distributed throughout the tissue. This was confirmed by immunofluorescence.
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Cited by
Collagen fibrillogenesis in vitro: interaction of types I and V collagen regulates fibril diameter
Birk, D. E., Fitch, J. M., Babiarz, J. P., Doane, K. J., & Linsenmayer, T. F. (1990) · Journal of Cell Science · doi:10.1242/jcs.95.4.649 · Cited by 596
Maciewicz, R. A., Wotton, S. F., Etherington, D. J., & Duance, V. C. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81151-d · Cited by 147
Hughes, A., Oxford, A., Tawara, K., Jorcyk, C., & Oxford, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030665 · Cited by 113
Metadata
- Authors
- Mendler, M., Eich-Bender, S. G., Vaughan, L., Winterhalter, K. H., & Bruckner, P.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1989-01-01
- Volume
- 108
- Issue
- 1
- Pages
- 191-197
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2078744277
- Cited by
- 509
- References
- 0
- FWCI
- 30.36
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cartilage contains mixed fibrils of collagen types II, IX, and XI. https://app.cochat.ai/papers/10.1083/jcb.108.1.191
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- Mendler, M., Eich-Bender, S. G., Vaughan, L., Winterhalter, K. H., & Bruckner, P. (1989). Cartilage contains mixed fibrils of collagen types II, IX, and XI. The Journal of cell biology. https://doi.org/10.1083/jcb.108.1.191
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.