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Cited by 509

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Cartilage contains mixed fibrils of collagen types II, IX, and XI.

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Mendler, M, Eich-Bender, S G, Vaughan, L, Winterhalter, K H, Bruckner, P·1989·The Journal of cell biology

Abstract

The distribution of collagen XI in fibril fragments from 17-d chick embryo sternal cartilage was determined by immunoelectron microscopy using specific polyclonal antibodies. The protein was distributed throughout the fibril fragments but was antigenically masked due to the tight packing of collagen molecules and could be identified only at sites where the fibril structure was partially disrupted. Collagens II and IX were also distributed uniformly along fibrils but, in contrast to collagen XI, were accessible to the antibodies in intact fibrils. Therefore, cartilage fibrils are heterotypically assembled from collagens II, IX, and XI. This implies that collagen XI is an integral component of the cartilage fibrillar network and homogeneously distributed throughout the tissue. This was confirmed by immunofluorescence.

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Metadata

Authors
Mendler, M., Eich-Bender, S. G., Vaughan, L., Winterhalter, K. H., & Bruckner, P.
Venue
The Journal of cell biology
Published
1989-01-01
Volume
108
Issue
1
Pages
191-197
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
OpenAlex
W2078744277
Cited by
509
References
0
FWCI
30.36
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Cartilage contains mixed fibrils of collagen types II, IX, and XI. https://app.cochat.ai/papers/10.1083/jcb.108.1.191
The paper
Mendler, M., Eich-Bender, S. G., Vaughan, L., Winterhalter, K. H., & Bruckner, P. (1989). Cartilage contains mixed fibrils of collagen types II, IX, and XI. The Journal of cell biology. https://doi.org/10.1083/jcb.108.1.191

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.