Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta.
Open accessAbstract
Transforming growth factors beta 1 and beta 2 bind with high affinity to the core protein of a 250-350-kD cell surface proteoglycan. This proteoglycan (formerly referred to as the type III TGF-beta receptor) coexists in many cells with the receptor implicated in TGF-beta signal transduction (type I TGF-beta receptor), but its function is not known. We report here that soluble TGF-beta-binding proteoglycans are released by several cell types into the culture media, and can be found in serum and extracellular matrices. As has been shown for the membrane-bound form, the soluble proteoglycans have a heterogeneous core protein of 100-120 kD that carries chondroitin sulfate and/or heparan sulfate glycosaminoglycan chains and a small amount of N-linked carbohydrate. The membrane-bound form of this proteoglycan is hydrophobic and associates with liposomes, whereas the soluble forms lack a membrane anchor and do not associate with liposomes. Differences in the electrophoretic migration of the soluble and membrane forms of this proteoglycan suggest additional structural differences in their core proteins and glycosaminoglycan chains. These soluble and membrane-bound proteoglycans, for which we propose the name "betaglycans," might play distinct roles in pericellular retention, delivery, or clearance of activated TGF-beta.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
TGFβR3 may act as a reservoir for TGFβ ligand, establishing a signaling environment for later in development.
“here TGFβR3 may act as a reservoir for TGFβ ligand, establishing a signaling environment for later in development”
From Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages (2020) · cites this paper as Andres et al., 1989
The paper proposes that betaglycan might help retain and deliver activated TGFβ locally (opening summary, p. 3137; discussion). That supports the hedged reservoir idea, but the paper does not connect this role to establishing a signaling environment for later in development. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Roberts, A. B., Sporn, M. B., Assoian, R. K., Smith, J. M., Roche, N. S., Wakefield, L. M., Heine, U., Liotta, L. A., Falanga, V., & Kehrl, J. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4167 · Cited by 2,867 · see citing works
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492 · see citing works
Self-citationHashimoto, C., Hudson, K., & Anderson, K. V. (1988) · Cell · doi:10.1016/0092-8674(88)90516-8 · Cited by 1,097 · see citing works
Role of transforming growth factor-beta in the development of the mouse embryo.
Heine, U., Munoz, E. F., Flanders, K. C., Ellingsworth, L. R., Lam, H. Y., Thompson, N. L., Roberts, A. B., & Sporn, M. B. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.6.2861 · Cited by 739 · see citing works
Fisher, L. W., Termine, J. D., & Young, M. F. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83781-4 · Cited by 703 · see citing works
The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors
Cheifetz, S., Weatherbee, J. A., Tsang, M., Anderson, J. K., Mole, J. E., Lucas, R., & Massagué, J. (1987) · Cell · doi:10.1016/0092-8674(87)90192-9 · Cited by 701 · see citing works
Self-citationThe TGF-β family of growth and differentiation factors
Massagué, J. (1987) · Cell · doi:10.1016/0092-8674(87)90443-0 · Cited by 672 · see citing works
Self-citationStamenkovic, I., Amiot, M., Pesando, J. M., & Seed, B. (1989) · Cell · doi:10.1016/0092-8674(89)90638-7 · Cited by 672 · see citing works
Goldstein, L. A., Zhou, D., Picker, L. J., Minty, C., Bargatze, R. F., Ding, J., & Butcher, E. C. (1989) · Cell · doi:10.1016/0092-8674(89)90639-9 · Cited by 556 · see citing works
Type beta transforming growth factor is an inhibitor of myogenic differentiation.
Massagué, J., Cheifetz, S., Endo, T., & Nadal‐Ginard, B. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.21.8206 · Cited by 550 · see citing works
Self-citationWakefield, L. M., Smith, D. M., Flanders, K. C., & Sporn, M. B. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68547-3 · Cited by 538 · see citing works
Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA.
Krusius, T., & Ruoslahti, E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.20.7683 · Cited by 529 · see citing works
Purification and characterization of two cartilage-inducing factors from bovine demineralized bone.
Seyedin, S. M., Thomas, T. C., Thompson, A. Y., Rosen, D. M., & Piez, K. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.8.2267 · Cited by 498 · see citing works
Cell adhesion protein receptors as targets for transforming growth factor-$beta; action
IGNOTZ, R. (1987) · Cell · doi:10.1016/0092-8674(87)90146-2 · Cited by 485 · see citing works
Bassols, A., & Massagué, J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69173-2 · Cited by 409 · see citing works
Self-citationOhta, M., Greenberger, J. S., Anklesaria, P. N., Bassols, A., & Massagué, J. (1987) · Nature · doi:10.1038/329539a0 · Cited by 392 · see citing works
Self-citationPROTEOGLYCAN CORE PROTEIN FAMILIES
Hassell, J. R., Kimura, J. H., & Hascall, V. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.002543 · Cited by 367 · see citing works
Type beta transforming growth factor controls the adipogenic differentiation of 3T3 fibroblasts.
Ignotz, R. A., & Massagué, J. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8530 · Cited by 363 · see citing works
Self-citationMassagué, J., & Like, B. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89408-x · Cited by 342 · see citing works
Self-citationBoyd, F. T., & Massagué, J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94172-4 · Cited by 314 · see citing works
Self-citationKoda, J. E., Rapraeger, A. C., & Bernfield, M. R. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39576-5 · Cited by 287 · see citing works
Glycosyl‐phosphatidylinositol: a versatile anchor for cell surface proteins 1
Low, M. G. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.5.2522071 · Cited by 267 · see citing works
Cheifetz, S., Andres, J., & Massagué, J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37487-8 · Cited by 242 · see citing works
Self-citationAlternative splicing generates a secreted form of N-CAM in muscle and brain
Gower, H. J., Barton, C. H., Elsom, V. L., Thompson, J., Moore, S. E., Dickson, G., & Walsh, F. S. (1988) · Cell · doi:10.1016/0092-8674(88)90241-3 · Cited by 241 · see citing works
Cellular distribution of type I and type II receptors for transforming growth factor-beta.
Cheifetz, S., Like, B., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67611-2 · Cited by 200 · see citing works
Self-citationAmyloid β Protein Precursor Is Possibly a Heparan Sulfate Proteoglycan Core Protein
Schubert, D. A., Schroeder, R., LaCorbiere, M., Saitoh, T., & Cole, G. M. (1988) · Science · doi:10.1126/science.2968652 · Cited by 190 · see citing works
Segarini, P. R., & Seyedin, S. M. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68486-8 · Cited by 180 · see citing works
Carrington, J. L., Roberts, A. B., Flanders, K. C., Roche, N. S., & Reddi, A. H. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.5.1969 · Cited by 155 · see citing works
Massagué, J. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88887-1 · Cited by 137 · see citing works
Self-citationCheifetz, S., Bassols, A., Stanley, K., Ohta, M., Greenberger, J. S., & Massagué, J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)38039-6 · Cited by 134 · see citing works
Self-citationStroynowski, I., Soloski, M. J., Low, M. G., & Hood, L. (1987) · Cell · doi:10.1016/0092-8674(87)90334-5 · Cited by 117 · see citing works
Transforming growth factor-β (TGF-β) receptor proteoglycan
Cheifetz, S., & Massagué, J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)80169-7 · Cited by 107 · see citing works
Self-citationA secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing.
Giblin, P. A., Ledbetter, J. A., & Kavathas, P. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.3.998 · Cited by 52 · see citing works
Miller, J., Hatch, J. A., Simonis, S., & Cullen, S. E. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.5.1359 · Cited by 48 · see citing works
Weitzhandler, M., Streeter, H. B., Henzel, W. J., & Bernfield, M. R. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68586-2 · Cited by 24 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dvorak, H. F., Brown, L. F., Detmar, M. J., & Dvořàk, A. M. (1995) · Europe PMC (PubMed Central) · Cited by 3,103 · see citing works
TGFβ signals through a heteromeric protein kinase receptor complex
Wrana, J. L., Attisano, L., Cárcamo, J. M., Zentella‐Dehesa, A., Doody, J. F., Laiho, M., Wang, X.-F., & Massagué, J. (1992) · Cell · doi:10.1016/0092-8674(92)90395-s · Cited by 1,528 · see citing works
Self-citationNegative regulation of transforming growth factor-β by the proteoglycan decorin
Yamaguchi, Y., Mann, D. M., & Ruoslahti, E. (1990) · Nature · doi:10.1038/346281a0 · Cited by 1,516 · see citing works
Proteoglycans as modulators of growth factor activities
Ruoslahti, E. I., & Yamaguchi, Y. (1991) · Cell · doi:10.1016/0092-8674(91)90308-l · Cited by 1,342 · see citing works
Regulation of development and differentiation by the extracellular matrix
Adams, J. C., & Watt, F. M. (1993) · Development · doi:10.1242/dev.117.4.1183 · Cited by 1,197 · see citing works
Park, J. E., Keller, G. A., & Ferrara, N. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.12.1317 · Cited by 1,123 · see citing works
Betaglycan presents ligand to the TGFβ signaling receptor
López‐Casillas, F., Wrana, J. L., & Massagué, J. (1993) · Cell · doi:10.1016/0092-8674(93)90368-z · Cited by 892 · see citing works
Self-citationVascular permeability factor (VPF, VEGF) in tumor biology
Senger, D. R., Water, L. V. D., Brown, L. F., Nagy, J. A., Yeo, K.-T., Yeo, T.-K., Berse, B., Jackman, R. W., Dvořàk, A. M., & Dvorak, H. F. (1993) · Cancer and Metastasis Reviews · doi:10.1007/bf00665960 · Cited by 840 · see citing works
Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation.
Laiho, M., DeCaprio, J. A., Ludlow, J. W., Livingston, D. M., & Massague, J. (1990) · Cell · doi:10.1016/0092-8674(90)90251-9 · Cited by 797 · see citing works
Self-citationBroekelmann, T. J., Limper, A. H., Colby, T. V., & McDonald, J. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.15.6642 · Cited by 794 · see citing works
Role of Transforming Growth Factor Beta in Human Cancer
Elliott, R. L., & Blobe, G. C. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.047 · Cited by 705 · see citing works
López‐Casillas, F., Cheifetz, S., Doody, J. F., Andres, J., Lane, W. S., & Massagué, J. (1991) · Cell · doi:10.1016/0092-8674(91)90073-8 · Cited by 676 · see citing works
Self-citationAttisano, L. (1993) · Cell · doi:10.1016/0092-8674(93)90488-c · Cited by 639 · see citing works
Expression cloning and characterization of the TGF-β type III receptor
Wang, X., Lin, H. Y.-F., Eaton, E. N., Downward, J., Lodish, H. F., & Weinberg, R. A. (1991) · Cell · doi:10.1016/0092-8674(91)90074-9 · Cited by 635 · see citing works
Hooper, N. M., Karran, E. H., & Turner, A. J. (1997) · Biochemical Journal · doi:10.1042/bj3210265 · Cited by 613 · see citing works
Keyt, B. A., Berleau, L. T., Nguyen, H. V., Chen, H., Heinsohn, H. G., VANDLEN, R. L., & Ferrara, N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.13.7788 · Cited by 603 · see citing works
Jones, J. I., Gockerman, A., Busby, W. H., Camacho-Hübner, C., & Clemmons, D. R. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.121.3.679 · Cited by 538 · see citing works
Transforming Growth Factor-β Gene Family Members and Bone*
Horowitz, M. C., Wozney, J. M., & McCarthy, T. L. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-1-27 · Cited by 496 · see citing works
TGF-β: Regulation of extracellular matrix
Roberts, A. B., McCune, B. K., & Sporn, M. B. (1992) · Kidney International · doi:10.1038/ki.1992.81 · Cited by 492 · see citing works
Gitay-Goren, H., Söker, S., Vlodavsky, I., & Neufeld, G. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42666-x · Cited by 490 · see citing works
Attisano, L., Wrana, J. L., Cheifetz, S., & Massagué, J. (1992) · Cell · doi:10.1016/0092-8674(92)90209-u · Cited by 468 · see citing works
Self-citationDesigning new treatment strategies in vital pulp therapy
Tziafas, D., Smith, A. J., & Lesot, H. (2000) · Journal of Dentistry · doi:10.1016/s0300-5712(99)00047-0 · Cited by 468 · see citing works
Doege, K. J., Sasaki, M., Kimura, T., & Yamada, Y. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35257-2 · Cited by 447 · see citing works
Kanzaki, T., Olofsson, A., Morén, A., Wernstedt, C., Hellman, U., Miyazono, K., Claesson, L., & Heldin, C. (1990) · Cell · doi:10.1016/0092-8674(90)90069-q · Cited by 446 · see citing works
Derynck, R., & Feng, X. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(97)00017-6 · Cited by 436 · see citing works
Transforming growth factor-alpha. A model for membrane-anchored growth factors.
Massagué, J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45745-6 · Cited by 424 · see citing works
Self-citationTransforming growth factor beta (TGF-?) in inflammation: A cause and a cure
Wahl, S. M. (1992) · Journal of Clinical Immunology · doi:10.1007/bf00918135 · Cited by 407 · see citing works
Endothelial–mesenchymal transition in atherosclerosis
Souilhol, C., Harmsen, M. C., Evans, P. C., & Krenning, G. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvx253 · Cited by 402 · see citing works
López‐Casillas, F., Payne, H., Andres, J., & Massagué, J. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.4.557 · Cited by 393 · see citing works
Self-citationMathematical modeling of tumor-induced angiogenesis
Mantzaris, N. V., Webb, S., & Othmer, H. G. (2004) · Journal of Mathematical Biology · doi:10.1007/s00285-003-0262-2 · Cited by 360 · see citing works
Cheifetz, S., Hernandez, H., Laiho, M., ten Dijke, P., Iwata, K. K., & Massagué, J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30535-5 · Cited by 348 · see citing works
Self-citationSaharinen, J., Hyytiäinen, M. M., Taipale, J., & Keski‐Oja, J. (1999) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(99)00010-6 · Cited by 315 · see citing works
Interactions of developing neurons with the extracellular matrix
Letourneau, P. C., Condic, M., & Snow, D. M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-00915.1994 · Cited by 304 · see citing works
Robey, P. G. (1989) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30347-5 · Cited by 297 · see citing works
Leptin Receptor (OB-R) Signaling
White, D. W., Kuropatwinski, K. K., Devos, R., Baumann, H., & Tartaglia, L. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4065 · Cited by 293 · see citing works
Ehlers, M. R., & Riordan, J. F. (1991) · Biochemistry · doi:10.1021/bi00106a001 · Cited by 281 · see citing works
Rauch, U., Gao, P., Janetzko, A., Flaccus, A., Hilgenberg, L., Tekotte, H., Margolis, R. K., & Margolis, R. U. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98755-7 · Cited by 267 · see citing works
Margolis, R. K., & Margolis, R. U. (1993) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923587 · Cited by 265 · see citing works
Kähäri, V., Larjava, H., & Uitto, J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99267-7 · Cited by 262 · see citing works
Lee, A. A., DILLMANN, W. H., McCulloch, A. D., & Villarreal, F. J. (1995) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(95)91983-x · Cited by 255 · see citing works
The emerging role of TGF-β superfamily coreceptors in cancer
Bernabéu, C., López-Novoa, J. M., & Quintanilla, M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.07.003 · Cited by 254 · see citing works
Vlodavsky, I., Korner, G., Ishai-Michaeli, R., Bashkin, P., Bar‐Shavit, R., & FUKS, Z. Y. (1990) · Cancer and Metastasis Reviews · doi:10.1007/bf00046361 · Cited by 250 · see citing works
The type III TGF-β receptor suppresses breast cancer progression
Dong, M., How, T., Kirkbride, K. C., Gordon, K. J., Lee, J. D., Hempel, N., Kelly, P., Moeller, B. J., Marks, J. R., & Blobe, G. C. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29293 · Cited by 246 · see citing works
Mechanisms of placental invasion of the uterus and their control
Graham, C. H., & Lala, P. K. (1992) · Biochemistry and Cell Biology · doi:10.1139/o92-135 · Cited by 245 · see citing works
Mertens, G., Cassiman, J. J., BERGHE, H. V. D., Vermylen, J., & David, G. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)88721-5 · Cited by 242 · see citing works
Tremellen, K. P., Seamark, R. F., & Robertson, S. A. (1998) · Biology of Reproduction · doi:10.1095/biolreprod58.5.1217 · Cited by 232 · see citing works
Growth factors and cutaneous wound repair
Martin, P. B., Hopkinson-Woolley, J. A., & McCluskey, J. T. (1992) · Progress in Growth Factor Research · doi:10.1016/0955-2235(92)90003-z · Cited by 231 · see citing works
Massagué, J., Cheifetz, S., Boyd, F. T., & Andres, J. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb16100.x · Cited by 231 · see citing works
Self-citationAn Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor
Martinez-Martín, N., Marcandalli, J., Huang, C., Arthur, C. P., Perotti, M., Foglierini, M., Ho, H., Dosey, A. M., Shriver, S. K., Payandeh, J., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.028 · Cited by 229 · see citing works
Transforming Growth Factor-β: Latent Forms, Binding Proteins and Receptors
Miyazono, K., Ichijo, H., & Heldin, C. (1993) · Growth Factors · doi:10.3109/08977199309029130 · Cited by 209 · see citing works
Control of Growth and Differentiation of Vascular Cells by Extracellular Matrix Proteins
Carey, D. J. (1991) · Annual Review of Physiology · doi:10.1146/annurev.ph.53.030191.001113 · Cited by 207 · see citing works
Ishai-Michaeli, R., Eldor, A., & Vlodavsky, I. (1990) · Cell Regulation · doi:10.1091/mbc.1.11.833 · Cited by 206 · see citing works
The types II and III transforming growth factor-beta receptors form homo-oligomers.
Henis, Y. I., Moustakas, A., Lin, H. Y.-F., & Lodish, H. F. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.1.139 · Cited by 205 · see citing works
Taipale, J., Koli, K., & Keski‐Oja, J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74051-4 · Cited by 201 · see citing works
TGF-β family co-receptor function and signaling
Nickel, J., Ten Dijke, P., & Mueller, T. D. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx126 · Cited by 198 · see citing works
Toma, I., & McCaffrey, T. A. (2011) · Cell and Tissue Research · doi:10.1007/s00441-011-1189-3 · Cited by 193 · see citing works
Keloid scarring: bench and bedside
Seifert, O., & Mrowietz, U. (2009) · Archives of Dermatological Research · doi:10.1007/s00403-009-0952-8 · Cited by 183 · see citing works
Roles for the type III TGF-β receptor in human cancer
Gatza, C. E., Oh, S. Y., & Blobe, G. C. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.01.016 · Cited by 181 · see citing works
Receptors for Transforming Growth Factor-β
Miyazono, K., ten Dijke, P., Ichijo, H., & Heldin, C. (1993) · Advances in immunology · doi:10.1016/s0065-2776(08)60510-6 · Cited by 177 · see citing works
Moustakas, A., Lin, H. Y.-F., Henis, Y. I., Plamondon, J., O'Connor‐McCourt, M. D., & Lodish, H. F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41509-8 · Cited by 181 · see citing works
Olofsson, A., Miyazono, K., Kanzaki, T., Colosetti, P., Engström, U., & Heldin, C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41801-7 · Cited by 178 · see citing works
Odekon, L. E., Blasi, F., & Rifkin, D. B. (1994) · Journal of Cellular Physiology · doi:10.1002/jcp.1041580303 · Cited by 178 · see citing works
The extracellular regulation of growth factor action.
Flaumenhaft, R. C., & Rifkin, D. B. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.10.1057 · Cited by 177 · see citing works
Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences.
Raines, E. W., & Ross, R. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.116.2.533 · Cited by 177 · see citing works
TGF-β and the Smad signal transduction pathway
Mehra, A., & Wrana, J. L. (2002) · Biochemistry and Cell Biology · doi:10.1139/o02-161 · Cited by 175 · see citing works
Kokenyesi, R., & Bernfield, M. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32716-3 · Cited by 173 · see citing works
Integration of the TGF-β pathway into the cellular signalling network
Lutz, M., & Knaus, P. I. (2002) · Cellular Signalling · doi:10.1016/s0898-6568(02)00058-x · Cited by 168 · see citing works
Esparza‐López, J., Montiel-Hernández, J. L., Vilchis‐Landeros, M. M., Okadome, T., Miyazono, K., & López‐Casillas, F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008866200 · Cited by 164 · see citing works
Centrella, M., McCarthy, T. L., & CANALIS, E. M. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.9.4490 · Cited by 164 · see citing works
Receptors for the TGF-β superfamily: multiple polypeptides and serine/threonine kinases
Lin, H. Y.-F., & Lodish, H. F. (1993) · Trends in Cell Biology · doi:10.1016/0962-8924(93)90195-7 · Cited by 163 · see citing works
Binding of two growth factor families to separate domains of the proteoglycan betaglycan.
Andres, J., DeFalcis, D., Noda, M., & Massagué, J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42643-9 · Cited by 160 · see citing works
Self-citationRole of heparan sulfate as a tissue-specific regulator of FGF-4 and FGF receptor recognition
Allen, B. L., Filla, M. S., & Rapraeger, A. C. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200106075 · Cited by 154 · see citing works
Betaglycan Inhibits TGF-β Signaling by Preventing Type I-Type II Receptor Complex Formation
Eickelberg, O., Reiß, M., Kashgarian, M. J., & Wells, R. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m105110200 · Cited by 149 · see citing works
Sanderson, R. D., Yang, Y., Kelly, T. J., MacLeod, V., Dai, Y., & Theus, A. M. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20602 · Cited by 147 · see citing works
Velasco-Loyden, G., Arribas, J., & López‐Casillas, F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306499200 · Cited by 144 · see citing works
Kaiser, U. B., Lee, B. L., Carroll, R. S., Unabia, G. C., Chin, W. W., & Childs, G. V. (1992) · Endocrinology · doi:10.1210/en.130.5.3048 · Cited by 144 · see citing works
Heparan Sulfate Core Proteins in Cell-Cell Signaling
Kramer, K. L., & Yost, H. J. (2003) · Annual Review of Genetics · doi:10.1146/annurev.genet.37.061103.090226 · Cited by 142 · see citing works
Proteoglycan signaling co-receptors: Roles in cell adhesion, migration and invasion
Mythreye, K., & Blobe, G. C. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.05.001 · Cited by 141 · see citing works
Droguett, R., Cabello‐Verrugio, C., Riquelme, C. A., & Brandan, E. (2006) · Matrix Biology · doi:10.1016/j.matbio.2006.04.004 · Cited by 140 · see citing works
Godyna, S., Liau, G., Popa, I., Stefansson, S., & Argraves, W. S. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.5.1403 · Cited by 140 · see citing works
LaMarre, J., Hayes, M. A., Wollenberg, G. K., Hussaini, I. M., Hall, S. W., & Gonias, S. L. (1991) · Journal of Clinical Investigation · doi:10.1172/jci114998 · Cited by 137 · see citing works
Transforming growth factor-β and its role in asthma
Duvernelle, C., Freund‐Michel, V., & Frossard, N. (2003) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/s1094-5539(03)00051-8 · Cited by 133 · see citing works
Massagué, J., Andres, J., Attisano, L., Cheifetz, S., López‐Casillas, F., Ohtsuki, M., & Wrana, J. L. (1992) · Molecular Reproduction and Development · doi:10.1002/mrd.1080320204 · Cited by 135 · see citing works
Self-citationTissue architecture and breast cancer: the role of extracellular matrix and steroid\nhormones
Hansen, R. K. (2000) · eScholarship (California Digital Library) · Cited by 134 · see citing works
Ultrastructural Localisation of TGF-β Exposure in Dentine by Chemical Treatment
Zhao, S., Sloan, A. J., Murray, P. E., Lumley, P. J., & Smith, A. J. (2000) · The Histochemical Journal · doi:10.1023/a:1004100518245 · Cited by 133 · see citing works
Extracellular matrix regulation of growth factor and protease activity
Flaumenhaft, R., & Rifkin, D. B. (1991) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(91)90055-4 · Cited by 130 · see citing works
Heparan sulfate proteoglycans in glomerular inflammation
Rops, A. L. W. M. M., van der Vlag, J., Lensen, J. F. M., Wijnhoven, T. J. M., van den Heuvel, L. P. W. J., Kuppevelt, T. H. V., & Berden, J. H. M. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00451.x · Cited by 129 · see citing works
Transforming growth factor-β in calf articular cartilage organ cultures: Synthesis and distribution
Morales, T. I., Joyce, M. E., Sobel, M. E., Danielpour, D., & Roberts, A. B. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90212-2 · Cited by 128 · see citing works
Arribas, J., López‐Casillas, F., & Massagué, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.17160 · Cited by 125 · see citing works
Self-citationType III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment
Hanks, B. A., Holtzhausen, A., Evans, K. S., Jamieson, R., Gimpel, P., Campbell, O. M., Hector-Greene, M., Sun, L., Tewari, A. K., George, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65745 · Cited by 120 · see citing works
Coker, R. K. (2001) · Thorax · doi:10.1136/thorax.56.7.549 · Cited by 118 · see citing works
Betaglycan: A multifunctional accessory
Bilandzic, M., & Stenvers, K. L. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.04.014 · Cited by 115 · see citing works
Canning, D. R., Höke, A., Malemud, C. J., & Silver, J. (1996) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(96)00004-4 · Cited by 113 · see citing works
Mertens, G., der Schueren, B. V., BERGHE, H. V. D., & David, G. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.132.3.487 · Cited by 111 · see citing works
Tamada, H., Das, S., Andrews, G. K., & Dey, S. K. (1991) · Biology of Reproduction · doi:10.1095/biolreprod45.2.365 · Cited by 111 · see citing works
Active Transforming Growth Factor-β in Wound Repair
Yang, L., Qiu, C. X., Ludlow, A., Ferguson, M. W. J., & Brunner, G. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65256-x · Cited by 105 · see citing works
Herndon, M. E., Stipp, C. S., & Lander, A. D. (1999) · Glycobiology · doi:10.1093/glycob/9.2.143 · Cited by 105 · see citing works
Angiogenin supports endothelial and fibroblast cell adhesion.
Soncin, F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.6.2232 · Cited by 103 · see citing works
Zentella‐Dehesa, A., Weis, F. M., Ralph, D. A., Laiho, M., & Massagué, J. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.10.4952 · Cited by 104 · see citing works
Self-citationTGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies
Hachana, S., & Larrivée, B. (2022) · Cells · doi:10.3390/cells11152336 · Cited by 104 · see citing works
- Authors
- Andres, J. L., Stanley, K., Cheifetz, S., & Massagué, J.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- ORCID
- Massagué, J
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1989-12-01
- Volume
- 109
- Issue
- 6
- Pages
- 3137-3145
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2115961
- OpenAlex
- W2117901334
- Cited by
- 354
- References
- 35
- Citations by year
- 2026: 1 · 2024: 13 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 1 · 2015: 2 · 2014: 6 · 2013: 4 · 2012: 2
- FWCI
- 14.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Cell Biology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (CA34610)
- National Cancer Institute (CA34610)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- betaglycan, TGF-beta type I receptor, chondroitin sulfate, heparan sulfate, glycosaminoglycan chains, extracellular matrix
- MeSH terms
- Animals, Cell Line, Cell Membrane, Cells, Cultured, Chromatography, Affinity, Chromatography, Ion Exchange, Cytosol, Humans, Kinetics, Liposomes, Molecular Weight, Protein Binding, Proteoglycans, Transforming Growth Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
