The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta.
Open accessAbstract
Transforming growth factors beta 1 and beta 2 bind with high affinity to the core protein of a 250-350-kD cell surface proteoglycan. This proteoglycan (formerly referred to as the type III TGF-beta receptor) coexists in many cells with the receptor implicated in TGF-beta signal transduction (type I TGF-beta receptor), but its function is not known. We report here that soluble TGF-beta-binding proteoglycans are released by several cell types into the culture media, and can be found in serum and extracellular matrices. As has been shown for the membrane-bound form, the soluble proteoglycans have a heterogeneous core protein of 100-120 kD that carries chondroitin sulfate and/or heparan sulfate glycosaminoglycan chains and a small amount of N-linked carbohydrate. The membrane-bound form of this proteoglycan is hydrophobic and associates with liposomes, whereas the soluble forms lack a membrane anchor and do not associate with liposomes. Differences in the electrophoretic migration of the soluble and membrane forms of this proteoglycan suggest additional structural differences in their core proteins and glycosaminoglycan chains. These soluble and membrane-bound proteoglycans, for which we propose the name "betaglycans," might play distinct roles in pericellular retention, delivery, or clearance of activated TGF-beta.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“here TGFβR3 may act as a reservoir for TGFβ ligand, establishing a signaling environment for later in development”
From Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages (2020) · cites this paper as Andres et al., 1989
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Roberts, A. B., Sporn, M. B., Assoian, R. K., Smith, J. M., Roche, N. S., Wakefield, L. M., Heine, U., Liotta, L. A., Falanga, V., & Kehrl, J. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4167 · Cited by 2,867
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Self-citationHashimoto, C., Hudson, K., & Anderson, K. V. (1988) · Cell · doi:10.1016/0092-8674(88)90516-8 · Cited by 1,097
Role of transforming growth factor-beta in the development of the mouse embryo.
Heine, U., Munoz, E. F., Flanders, K. C., Ellingsworth, L. R., Lam, H. Y., Thompson, N. L., Roberts, A. B., & Sporn, M. B. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.6.2861 · Cited by 739
Fisher, L. W., Termine, J. D., & Young, M. F. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83781-4 · Cited by 703
The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors
Cheifetz, S., Weatherbee, J. A., Tsang, M., Anderson, J. K., Mole, J. E., Lucas, R., & Massagué, J. (1987) · Cell · doi:10.1016/0092-8674(87)90192-9 · Cited by 701
Self-citationThe TGF-β family of growth and differentiation factors
Massagué, J. (1987) · Cell · doi:10.1016/0092-8674(87)90443-0 · Cited by 672
Self-citationStamenkovic, I., Amiot, M., Pesando, J. M., & Seed, B. (1989) · Cell · doi:10.1016/0092-8674(89)90638-7 · Cited by 672
Type beta transforming growth factor is an inhibitor of myogenic differentiation.
Massagué, J., Cheifetz, S., Endo, T., & Nadal‐Ginard, B. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.21.8206 · Cited by 560
Self-citationGoldstein, L. A., Zhou, D., Picker, L. J., Minty, C., Bargatze, R. F., Ding, J., & Butcher, E. C. (1989) · Cell · doi:10.1016/0092-8674(89)90639-9 · Cited by 556
Wakefield, L. M., Smith, D. M., Flanders, K. C., & Sporn, M. B. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68547-3 · Cited by 534
Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA.
Krusius, T., & Ruoslahti, E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.20.7683 · Cited by 529
Purification and characterization of two cartilage-inducing factors from bovine demineralized bone.
Seyedin, S. M., Thomas, T. C., Thompson, A. Y., Rosen, D. M., & Piez, K. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.8.2267 · Cited by 498
Cell adhesion protein receptors as targets for transforming growth factor-$beta; action
IGNOTZ, R. (1987) · Cell · doi:10.1016/0092-8674(87)90146-2 · Cited by 485
Bassols, A., & Massagué, J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69173-2 · Cited by 409
Self-citationOhta, M., Greenberger, J. S., Anklesaria, P. N., Bassols, A., & Massagué, J. (1987) · Nature · doi:10.1038/329539a0 · Cited by 392
Self-citationPROTEOGLYCAN CORE PROTEIN FAMILIES
Hassell, J. R., Kimura, J. H., & Hascall, V. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.002543 · Cited by 367
Type beta transforming growth factor controls the adipogenic differentiation of 3T3 fibroblasts.
Ignotz, R. A., & Massagué, J. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8530 · Cited by 363
Self-citationMassagué, J., & Like, B. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89408-x · Cited by 342
Self-citationBoyd, F. T., & Massagué, J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94172-4 · Cited by 314
Self-citationKoda, J. E., Rapraeger, A. C., & Bernfield, M. R. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39576-5 · Cited by 287
Glycosyl‐phosphatidylinositol: a versatile anchor for cell surface proteins 1
Low, M. G. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.5.2522071 · Cited by 267
Cheifetz, S., Andres, J., & Massagué, J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37487-8 · Cited by 242
Self-citationAlternative splicing generates a secreted form of N-CAM in muscle and brain
Gower, H. J., Barton, C. H., Elsom, V. L., Thompson, J., Moore, S. E., Dickson, G., & Walsh, F. S. (1988) · Cell · doi:10.1016/0092-8674(88)90241-3 · Cited by 241
Cellular distribution of type I and type II receptors for transforming growth factor-beta.
Cheifetz, S., Like, B., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67611-2 · Cited by 200
Self-citationAmyloid β Protein Precursor Is Possibly a Heparan Sulfate Proteoglycan Core Protein
Schubert, D. A., Schroeder, R., LaCorbiere, M., Saitoh, T., & Cole, G. M. (1988) · Science · doi:10.1126/science.2968652 · Cited by 190
Segarini, P. R., & Seyedin, S. M. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68486-8 · Cited by 180
Carrington, J. L., Roberts, A. B., Flanders, K. C., Roche, N. S., & Reddi, A. H. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.5.1969 · Cited by 154
Massagué, J. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88887-1 · Cited by 137
Self-citationCheifetz, S., Bassols, A., Stanley, K., Ohta, M., Greenberger, J. S., & Massagué, J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)38039-6 · Cited by 134
Self-citationStroynowski, I., Soloski, M. J., Low, M. G., & Hood, L. (1987) · Cell · doi:10.1016/0092-8674(87)90334-5 · Cited by 117
Transforming growth factor-β (TGF-β) receptor proteoglycan
Cheifetz, S., & Massagué, J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)80169-7 · Cited by 107
Self-citationA secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing.
Giblin, P. A., Ledbetter, J. A., & Kavathas, P. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.3.998 · Cited by 52
Miller, J., Hatch, J. A., Simonis, S., & Cullen, S. E. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.5.1359 · Cited by 48
Weitzhandler, M., Streeter, H. B., Henzel, W. J., & Bernfield, M. R. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68586-2 · Cited by 24
Flagged first, then by citations
Cited by
Sorted by citations
Dvorak, H. F., Brown, L. F., Detmar, M. J., & Dvořàk, A. M. (1995) · Europe PMC (PubMed Central) · Cited by 3,100
TGFβ signals through a heteromeric protein kinase receptor complex
Wrana, J. L., Attisano, L., Cárcamo, J. M., Zentella‐Dehesa, A., Doody, J. F., Laiho, M., Wang, X.-F., & Massagué, J. (1992) · Cell · doi:10.1016/0092-8674(92)90395-s · Cited by 1,528
Self-citationNegative regulation of transforming growth factor-β by the proteoglycan decorin
Yamaguchi, Y., Mann, D. M., & Ruoslahti, E. (1990) · Nature · doi:10.1038/346281a0 · Cited by 1,516
Proteoglycans as modulators of growth factor activities
Ruoslahti, E. I., & Yamaguchi, Y. (1991) · Cell · doi:10.1016/0092-8674(91)90308-l · Cited by 1,342
Regulation of development and differentiation by the extracellular matrix
Adams, J. C., & Watt, F. M. (1993) · Development · doi:10.1242/dev.117.4.1183 · Cited by 1,207
Metadata
- Authors
- Andres, J. L., Stanley, K., Cheifetz, S., & Massagué, J.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- ORCID
- Massagué, J
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1989-12-01
- Volume
- 109
- Issue
- 6
- Pages
- 3137-3145
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2115961
- OpenAlex
- W2117901334
- Cited by
- 354
- References
- 35
- Citations by year
- 2026: 1 · 2024: 13 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 1 · 2015: 2 · 2014: 6 · 2013: 4 · 2012: 2
- FWCI
- 14.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Cell Biology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (CA34610)
- National Cancer Institute (CA34610)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- betaglycan, TGF-beta type I receptor, chondroitin sulfate, heparan sulfate, glycosaminoglycan chains, extracellular matrix
- MeSH terms
- Animals, Cell Line, Cell Membrane, Cells, Cultured, Chromatography, Affinity, Chromatography, Ion Exchange, Cytosol, Humans, Kinetics, Liposomes, Molecular Weight, Protein Binding, Proteoglycans, Transforming Growth Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
