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Transforming growth factors-beta 1 and beta 2 are mitogens for rat Schwann cells.
Open accessAbstract
Transforming growth factor-beta 1 (TGF-beta 1) and TGF-beta 2 were found to be potent mitogens for purified rat Schwann cells, each stimulating DNA synthesis in quiescent cells and also increasing their proliferation rate. Half-maximal stimulation of DNA synthesis occurred at approximately 0.1 ng/ml TGF-beta 1 or TGF-beta 2. Mitogenic stimulation by TGF-beta 1 and TGF-beta 2 was enhanced by forskolin, which activates adenylate cyclase, at concentrations up to 0.5 microM forskolin. However, at 5 microM forskolin, the synergistic interaction between forskolin and TGF-beta 1 was abolished. These results are in contrast to the observed synergy between forskolin and another Schwann cell mitogen, glial growth factor (GGF). Both 0.5 and 5 microM forskolin were found to enhance the stimulation of DNA synthesis by partially purified GGF (GGF-CM). As well as being functionally distinct, TGF-beta 1 and GGF-CM activities were also physically separable by chromatography on a Superose 12 gel permeation column. Thus, TGF-beta 1 and beta 2 are rat Schwann cell mitogens, and Schwann cells are one of the few normal cell populations to respond mitogenically to TGF-beta.
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Cited by
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Localization and actions of transforming growth factor-β s in the embryonic nervous system
Flanders, K. C., Lüdecke, G., Engels, S., Cissel, D. S., Roberts, A. B., Kondaiah, P., Lafyatis, R., Sporn, M. B., & Unsicker, K. (1991) · Development · doi:10.1242/dev.113.1.183 · Cited by 359
Metadata
- Authors
- Ridley, A. J., Davis, J. B., Stroobant, P., & Land, H.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1989-12-01
- Volume
- 109
- Issue
- 6
- Pages
- 3419-3424
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2131497800
- Cited by
- 186
- References
- 0
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Transforming growth factors-beta 1 and beta 2 are mitogens for rat Schwann cells. https://app.cochat.ai/papers/10.1083/jcb.109.6.3419
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- Ridley, A. J., Davis, J. B., Stroobant, P., & Land, H. (1989). Transforming growth factors-beta 1 and beta 2 are mitogens for rat Schwann cells. The Journal of cell biology. https://doi.org/10.1083/jcb.109.6.3419
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