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Cited by 295

Localization and actions of transforming growth factor-β s in the embryonic nervous system

Flanders, Kathleen C., Lüdecke, Gerson, Engels, Sibelle, Cissel, David S., Roberts, Anita B., Kondaiah, Paturu, Lafyatis, Robert, Sporn, Michael B. +1 more·1991·Development
DOI 10.1242/dev.113.1.183
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Abstract

We present evidence for unique localization and specific biological activities for transforming growth factor-βs (TGF-βs) 2 and 3, as compared to TGF-β1, in the nervous system of the 12– 18 day mouse embryo. Each TGF-β isoform was localized immunohistochemically by specific antibodies raised to peptides corresponding to unique sequences in the respective TGF-β proteins. Staining for TGF-β1 was principally in the meninges, while TGF-βs 2 and 3 co-localized in neuronal perikarya and axons, as well as in radial glial cells. In the central nervous system, staining was most prominent in zones where neuronal differentiation occurs and less intense in zones of active proliferation, while in the peripheral nervous system, many nerve fibers as well as their cell bodies were strongly immunoreactive for TGF-βs 2 and 3. Functionally, we have also found that in the presence of an extract of chick eye tissue, TGF-βs 2 and 3 inhibit survival of cultured embryonic chick ciliary ganglionic neurons in a dose-dependent fashion; TGF-β1 shows no inhibitory effects. Our data suggest that TGF-β 2 and 3 may play a role in regulation of neuronal migration and differentiation, as well as in glial cell proliferation and differentiation.

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  • TGF-β and their receptors are expressed at low levels by both neurons and glial cells, and their expression is upregulated in response to a wide range of neuronal insults and during aging.

    “TGF-β and their receptors are expressed at low levels by both neurons and glial cells42,43, and their expression is upregulated in response to a wide range of neuronal insults and during aging44,45.”

    From Identification of a unique TGF-β–dependent molecular and functional signature in microglia (2014) · cites this paper as [42]

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Authors
Flanders, K. C., Lüdecke, G., Engels, S., Cissel, D. S., Roberts, A. B., Kondaiah, P., Lafyatis, R., Sporn, M. B., & Unsicker, K.
Affiliations
  • 1 Laboratory of Chemoprevention, National Cancer Institute, Building 41, Bethesda, MD 20892 USA
  • University of Marburg, Marburg, Germany 2 Department of Anatomy and Cell Biology ,
Venue
Development
Publisher
The Company of Biologists
Published
1991-01-09
Volume
113
Issue
1
Pages
183-191
ISSN
  • 0950-1991
  • 1477-9129
DOI
10.1242/dev.113.1.183
Cited by
295
References
0
Language
en
Licence
www.biologists.com/user-licence-1-1/ (vor)

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