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Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast.
Open accessAbstract
BiP/GRP78 is an essential member of the HSP70 family that resides in the lumen of the endoplasmic reticulum. In yeast, BiP/GRP78 is encoded by the KAR2 gene. A temperature sensitive mutation was isolated in KAR2 and found to cause a rapid block in protein secretion. Secretory precursors of a number of proteins (invertase, carboxypeptidase Y, alpha-factor, and BiP) accumulated that were characteristic of a block in translocation into the lumen of the ER. Protease protection experiments confirmed that the precursors accumulated on the cytoplasmic side of the ER membrane. Moreover, depletion of wild-type KAR2 protein also resulted in a block in translocation of secretory proteins. These results implicate BiP/GRP78 function in the continued translocation of proteins into the lumen of the ER.
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Cites
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
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Wiertz, E. J. H. J., Jones, T. R., Sun, L., Bogyo, M., Geuze, H. J., & Ploegh, H. L. (1996) · Cell · doi:10.1016/s0092-8674(00)81054-5 · Cited by 1,072
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Metadata
- Authors
- Vogel, J. P., Misra, L. M., & Rose, M. D.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1990-06-01
- Volume
- 110
- Issue
- 6
- Pages
- 1885-1895
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2111538369
- Cited by
- 432
- References
- 2
- FWCI
- 25.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vogel, J. P., Misra, L. M., & Rose, M. D. (1990). Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast. The Journal of cell biology. https://doi.org/10.1083/jcb.110.6.1885
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
