The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Heterogeneity of microvascular pericytes for smooth muscle type alpha-actin.
Open accessAbstract
Microvascular pericytes are believed to be involved in various functions such as regulation of capillary blood flow and endothelial proliferation. Since pericytes represent a morphologically heterogeneous cell population ranging from circular smooth musclelike to elongated fibroblast-like morphology it is possible that regulation of blood flow (via contractility) and control of endothelial proliferation (as well as other metabolic functions) may be accomplished by different subsets of pericytes. In the present study we provide evidence for heterogeneity of pericytes at the molecular level by using two novel technical approaches. These are (a) immunostaining of whole mounts of the microvascular beds of the rat mesentery and bovine retina and (b) immunoblotting studies of microdissected retinal microvessels. We show that pericytes of true capillaries (midcapillaries) apparently lack the smooth muscle isoform of alpha-actin whereas transitional pericytes of pre- and postcapillary microvascular segments do express this isoform. Thus, regulation of capillary blood flow may be accomplished by the smooth muscle-related pre- and postcapillary pericytes whereas the nonmuscle pericytes of true capillaries may play a role in other functions.
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Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells.
Orlidge, A., & D'Amore, P. A. (1987) · The Journal of cell biology · doi:10.1083/jcb.105.3.1455 · Cited by 611
Microvascular pericytes contain muscle and nonmuscle actins.
Herman, I. M., & D'Amore, P. A. (1985) · The Journal of cell biology · doi:10.1083/jcb.101.1.43 · Cited by 402
Skalli, O., Pelte, M. F., Peclet, M. C., Gabbiani, G., Gugliotta, P., Bussolati, G., Ravazzola, M., & Orci, L. (1989) · Journal of Histochemistry & Cytochemistry · doi:10.1177/37.3.2918221 · Cited by 373
Topography and function of the mesenteric capillary circulation
Chambers, R., & Zweifach, B. W. (1944) · American Journal of Anatomy · doi:10.1002/aja.1000750204 · Cited by 365
Retinal Vascular Patterns: VI. Mural Cells of the Retinal Capillaries
KUWABARA, T. (1963) · Archives of Ophthalmology · doi:10.1001/archopht.1963.00960040498013 · Cited by 331
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Self-citationMicrovascular pericyte contractility in vitro: comparison with other cells of the vascular wall.
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“Mural cells have two subtypes: pericytes, which associate with capillaries, and smooth muscle alpha actin (SMA) cells, which associate with larger-bore vasculature and control blood flow (Hill et al., 2015; Hughes and Chan-Ling, 2004; Nehls and Drenckhahn, 1991).”
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Metadata
- Authors
- Nehls, V, & Drenckhahn, D.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1991-04-01
- Volume
- 113
- Issue
- 1
- Pages
- 147-154
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2112219075
- Cited by
- 386
- References
- 18
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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