The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by E-cadherin.
Open accessAbstract
Gap junctional intercellular communication (GJIC) of cultured mouse epidermal cells is mediated by a gap junction protein, connexin 43, and is dependent on the calcium concentration in the medium, with higher GJIC in a high-calcium (1.2 mM) medium. In several mouse epidermal cell lines, we found a good correlation between the level of GJIC and that of immunohistochemical staining of E-cadherin, a calcium-dependent cell adhesion molecule, at cell-cell contact areas. The variant cell line P3/22 showed both low GJIC and E-cadherin protein expression in low- and high-Ca2+ media. P3/22 cells showed very low E-cadherin mRNA expression. To test directly whether E-cadherin is involved in the Ca(2+)-dependent regulation of GJIC, we transfected the E-cadherin expression vector into P3/22 cells and obtained several stable clones which expressed high levels of E-cadherin mRNA. All transfectants expressed E-cadherin molecules at cell-cell contact areas in a calcium-dependent manner. GJIC was also observed in these transfectants and was calcium dependent. These results suggest that Ca(2+)-dependent regulation of GJIC in mouse epidermal cells is directly controlled by a calcium-dependent cell adhesion molecule, E-cadherin. Furthermore, several lines of evidence suggest that GJIC control by E-cadherin involves posttranslational regulation (assembly and/or function) of the gap junction protein connexin 43.
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Cites
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Cited by
Connections with Connexins: the Molecular Basis of Direct Intercellular Signaling
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Regulation of Gap Junctions by Phosphorylation of Connexins
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Gap junctions and connexin-interacting proteins
Giepmans, B. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.12.009 · Cited by 450
Metadata
- Authors
- Jongen, W. M., Fitzgerald, D. J., Asamoto, M., Piccoli, C., Slaga, T. J., Gros, D., Takeichi, M., & Yamasaki, H.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1991-08-01
- Volume
- 114
- Issue
- 3
- Pages
- 545-555
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2072228548
- Cited by
- 364
- References
- 41
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by E-cadherin. https://app.cochat.ai/papers/10.1083/jcb.114.3.545
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- Jongen, W. M., Fitzgerald, D. J., Asamoto, M., Piccoli, C., Slaga, T. J., Gros, D., Takeichi, M., & Yamasaki, H. (1991). Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by E-cadherin. The Journal of cell biology. https://doi.org/10.1083/jcb.114.3.545
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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