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Macromolecular organization of chicken type X collagen in vitro.
Open accessAbstract
The macromolecular structure of type X collagen in the matrices of primary cultures of chick hypertrophic chondrocytes was initially investigated using immunoelectron microscopy. Type X collagen was observed to assemble into a matlike structure with-in the matrix elaborated by hypertrophic chondrocytes. The process of self assembly was investigated at the molecular level using purified chick type X collagen and rotary-shadowing EM. It was shown that under neutral conditions at 34 degrees C, individual type X collagen molecules associate rapidly into multimeric clusters via their carboxy-terminal globular domains forming structures with a central nodule of carboxy-terminal domains and the triple helices radiating outwards. Prolonged incubation resulted in the formation of a regular hexagonal lattice by lateral association of the juxtaposed triple-helical domains from adjacent multimeric clusters. This extended lattice may play an important role in modifying the cartilage matrix for subsequent events occurring in endochondral bone formation.
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Cited by
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Singh, B., Fleury, C., Jalalvand, F., & Riesbeck, K. (2012) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2012.00340.x · Cited by 302
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Warman, M. L., Abbott, M., Apte, S. S., Hefferon, T., McIntosh, I., Cohn, D. H., Hecht, J. T., Olsen, B. R., & Francomano, C. A. (1993) · Nature Genetics · doi:10.1038/ng0993-79 · Cited by 261
Hayward, C., Shu, X., Cideciyan, A. V., Lennon, A., Barran, P., Zareparsi, S., Sawyer, L., Hendry, G., Dhillon, B., Milam, A. H., et al. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg289 · Cited by 191
Metadata
- Authors
- Kwan, A. P., Cummings, C. E., Chapman, J. A., & Grant, M. E.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1991-08-01
- Volume
- 114
- Issue
- 3
- Pages
- 597-604
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2078867880
- Cited by
- 193
- References
- 0
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Kwan, A. P., Cummings, C. E., Chapman, J. A., & Grant, M. E. (1991). Macromolecular organization of chicken type X collagen in vitro. The Journal of cell biology. https://doi.org/10.1083/jcb.114.3.597
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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