The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cell surface receptors for herpes simplex virus are heparan sulfate proteoglycans.
Open accessAbstract
The role of cell surface heparan sulfate in herpes simplex virus (HSV) infection was investigated using CHO cell mutants defective in various aspects of glycosaminoglycan synthesis. Binding of radiolabeled virus to the cells and infection were assessed in mutant and wild-type cells. Virus bound efficiently to wild-type cells and initiated an abortive infection in which immediate-early or alpha viral genes were expressed, despite limited production of late viral proteins and progeny virus. Binding of virus to heparan sulfate-deficient mutant cells was severely impaired and mutant cells were resistant to HSV infection. Intermediate levels of binding and infection were observed for a CHO cell mutant that produced undersulfated heparan sulfate. These results show that heparan sulfate moieties of cell surface proteoglycans serve as receptors for HSV.
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Cites
Yayon, A., Klagsbrun, M., Esko, J. D., Leder, P., & Ornitz, D. M. (1991) · Cell · doi:10.1016/0092-8674(91)90512-w · Cited by 2,440
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Cited by
The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line
Xu, X., Nagarajan, H., Lewis, N. E., Pan, S., Cai, Z., Liu, X., Chen, W., Xie, M., Wang, W., Hammond, S., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1932 · Cited by 785
“, the addition of mouse genes encoding HS3ST to CHO-K1 cells renders them susceptible to HSV-1 infectio”
Microtubule-mediated transport of incoming herpes simplex virus 1 capsids to the nucleus
Sodeik, B., Ebersold, M. W., & Helenius, A. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.5.1007 · Cited by 687
Warner, M. S., Geraghty, R. J., Martinez, W. M., Montgomery, R. I., Whitbeck, J. C., Xu, R., Eisenberg, R. J., Cohen, G. H., & Spear, P. G. (1998) · Virology · doi:10.1006/viro.1998.9218 · Cited by 494
Self-citationMicrobial adherence to and invasion through proteoglycans
Rostand, K. S., & Esko, J. D. (1997) · Infection and Immunity · doi:10.1128/iai.65.1.1-8.1997 · Cited by 490
Self-citationHuman fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2
Qing, K., Mah, C., Hansen, J., Zhou, S., Dwarki, V., & Srivastava, A. (1999) · Nature Medicine · doi:10.1038/4758 · Cited by 443
Metadata
- Authors
- Shieh, M. T., WuDunn, D., Montgomery, R. I., Esko, J. D., & Spear, P. G.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1992-03-01
- Volume
- 116
- Issue
- 5
- Pages
- 1273-1281
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2130363568
- Cited by
- 545
- References
- 1
- FWCI
- 9.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Shieh, M. T., WuDunn, D., Montgomery, R. I., Esko, J. D., & Spear, P. G. (1992). Cell surface receptors for herpes simplex virus are heparan sulfate proteoglycans. The Journal of cell biology. https://doi.org/10.1083/jcb.116.5.1273
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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