The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Suppression of tumorigenicity in transformed cells after transfection with vinculin cDNA.
Open accessAbstract
Transfection of chicken vinculin cDNA into two tumor cell lines expressing diminished levels of the endogenous protein, brought about a drastic suppression of their tumorigenic ability. The SV-40-transformed Balb/c 3T3 line (SVT2) contains four times less vinculin than the parental 3T3 cells, and the rat adenocarcinoma BSp73ASML has no detectable vinculin. Restoration of vinculin in these cells, up to the levels found in 3T3 cells, resulted in an apparent increase in substrate adhesiveness, a decrease in the ability to grow in soft agar, and suppression of their capacity to develop tumors after injection into syngeneic hosts or nude mice. These results suggest that vinculin, a cytoplasmic component of cell-matrix and cell-cell adhesions, may have a major suppressive effect on the transformed phenotype.
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Cites
Vleminckx, K., Vakaet, L., Mareel, M., Fiers, W., & Van Roy, F. (1991) · Cell · doi:10.1016/0092-8674(91)90143-m · Cited by 1,656
Cited by
Whitfield, M. L., Sherlock, G., Saldanha, A. J., Murray, J. I., Ball, C. A., Alexander, K. E., Matese, J. C., Perou, C. M., Hurt, M. M., Brown, P. O., et al. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.02-02-0030 · Cited by 1,527
Cytoskeleton—Plasma Membrane Interactions
Luna, E. J., & Hitt, A. L. (1992) · Science · doi:10.1126/science.1439807 · Cited by 786
A role for Rho in Ras transformation
Qiu, R. G., Chen, J., McCormick, F., & Symons, M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11781 · Cited by 533
The structure and regulation of vinculin
Ziegler, W. H., Liddington, R. C., & Critchley, D. R. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.07.004 · Cited by 481
Prevention of tumor metastasis formation by anti-variant CD44.
Seiter, S., Arch, R., Reber, S., Komitowski, D., Hofmann, M., Ponta, H., Herrlich, P., Matzku, S., & Zöller, M. (1993) · The Journal of experimental medicine · doi:10.1084/jem.177.2.443 · Cited by 334
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Metadata
- Authors
- Rodríguez Fernández, J. L., Geiger, B., Salomon, D., Sabanay, I., Zöller, M., & Ben-Ze'ev, A.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1992-10-15
- Volume
- 119
- Issue
- 2
- Pages
- 427-438
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2143805521
- Cited by
- 225
- References
- 1
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Rodríguez Fernández, J. L., Geiger, B., Salomon, D., Sabanay, I., Zöller, M., & Ben-Ze'ev, A. (1992). Suppression of tumorigenicity in transformed cells after transfection with vinculin cDNA. The Journal of cell biology. https://doi.org/10.1083/jcb.119.2.427
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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