The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Recombinant human bone morphogenetic protein 2B stimulates PC12 cell differentiation: potentiation and binding to type IV collagen.
Open accessAbstract
Bone morphogenetic protein 2B (BMP 2B, also known as BMP 4) induces cartilage and bone morphogenesis in ectopic extraskeletal sites. BMP 2B is one of several bone morphogenetic proteins which along with activins and inhibins are members of the transforming growth factor-beta (TGF-beta) family. Both BMP 2B and activin A, but not TGF-beta 1, induce rat pheochromocytoma PC12 neuronal cell differentiation and expression of VGF, a nervous system-specific mRNA. PC12 cells exhibited approximately 2,500 receptors per cell for BMP 2B with an apparent dissociation constant of 19 pM. Extracellular matrix components, including fibronectin, laminin, and collagen type IV potentiated the activity of BMP and activin A, with the latter being the most active. Direct experiments demonstrated that radioiodinated BMP 2B bound to collagen type IV better than to either laminin or fibronectin. These data demonstrate a common neurotrophic activity of both BMP 2B and activin A, and suggest that these regulatory molecules alone and in conjunction with extracellular matrix components may play a role in both the development and repair of nervous tissue.
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The trk Proto-Oncogene Product: a Signal Transducing Receptor for Nerve Growth Factor
Kaplan, D. R., Hempstead, B. L., Martin-Zanca, D., Chao, M. V., & Parada, L. F. (1991) · Science · doi:10.1126/science.1850549 · Cited by 1,379
Cited by
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.
ten Dijke, P., Yamashita, H., Sampath, T. K., Reddi, A. H., Estevez, M., Riddle, D. L., Ichijo, H., Heldin, C. H., & Miyazono, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32506-1 · Cited by 730
Self-citationRuppert, R., Hoffmann, E., & Sebald, W. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0295n.x · Cited by 558
Characterization and Cloning of a Receptor for BMP-2 and BMP-4 from NIH 3T3 Cells
Koenig, B. B., Cook, J. S., Wolsing, D. H., Ting, J., Tiesman, J. P., Correa, P. E., Olson, C. A., Pecquet, A. L., Ventura, F., Grant, R. A., et al. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5961 · Cited by 366
Type IV collagens regulate BMP signalling in Drosophila
Wang, X., Harris, R. E., Bayston, L. J., & Ashe, H. L. (2008) · Nature · doi:10.1038/nature07214 · Cited by 337
Kuo, D. S., Labelle-Dumais, C., & Gould, D. B. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds346 · Cited by 320
Metadata
- Authors
- Paralkar, V. M., Weeks, B. S., Yu, Y. M., Kleinman, H. K., & Reddi, A. H.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1992-12-15
- Volume
- 119
- Issue
- 6
- Pages
- 1721-1728
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2032950084
- Cited by
- 161
- References
- 2
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Recombinant human bone morphogenetic protein 2B stimulates PC12 cell differentiation: potentiation and binding to type IV collagen. https://app.cochat.ai/papers/10.1083/jcb.119.6.1721
- The paper
- Paralkar, V. M., Weeks, B. S., Yu, Y. M., Kleinman, H. K., & Reddi, A. H. (1992). Recombinant human bone morphogenetic protein 2B stimulates PC12 cell differentiation: potentiation and binding to type IV collagen. The Journal of cell biology. https://doi.org/10.1083/jcb.119.6.1721
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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