The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mutations in human dynamin block an intermediate stage in coated vesicle formation
Open accessAbstract
The role of human dynamin in receptor-mediated endocytosis was investigated by transient expression of GTP-binding domain mutants in mammalian cells. Using assays which detect intermediates in coated vesicle formation, the dynamin mutants were found to block endocytosis at a stage after the initiation of coat assembly and preceding the sequestration of ligands into deeply invaginated coated pits. Membrane transport from the ER to the Golgi complex was unaffected indicating that dynamin mutants specifically block early events in endocytosis. These results demonstrate that mutations in the GTP-binding domain of dynamin block Tfn-endocytosis in mammalian cells and suggest that a functional dynamin GTPase is required for receptor-mediated endocytosis via clathrin-coated pits.
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Citations
Cites
The GTPase superfamily: conserved structure and molecular mechanism
Bourne, H. R., Sanders, D. A., & McCormick, F. (1991) · Nature · doi:10.1038/349117a0 · Cited by 3,392
Tisdale, E. J., Bourne, J. R., Khosravi-Far, R., Der, C. J., & Balch, W. E. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.4.749 · Cited by 500
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Cited by
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
McMahon, H. T., & Boucrot, E. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3151 · Cited by 2,223
Dynamin, a membrane-remodelling GTPase
Ferguson, S. M., & De Camilli, P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3266 · Cited by 992
Mitochondrial Dynamics in Mammalian Health and Disease
Liesa, M., Palacín, M., & Zorzano, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00030.2008 · Cited by 953
Araki, N., Johnson, M. T., & Swanson, J. A. (1996) · The Journal of cell biology · doi:10.1083/jcb.135.5.1249 · Cited by 949
“tein implicated in elathrin-mediated endocytosis (14, 34).”
Gandre-Babbe, S., & van der Bliek, A. M. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-12-1287 · Cited by 769
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Metadata
- Authors
- van der Bliek, A., Redelmeier, T., Damke, H., Tisdale, E., Meyerowitz, E., & Schmid, S.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1993-08-01
- Volume
- 122
- Issue
- 3
- Pages
- 553-563
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1961999388
- Cited by
- 698
- References
- 2
- FWCI
- 13.37
- Type
- journal article
- Language
- en
- Open access
- green
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- van der Bliek, A., Redelmeier, T., Damke, H., Tisdale, E., Meyerowitz, E., & Schmid, S. (1993). Mutations in human dynamin block an intermediate stage in coated vesicle formation. The Journal of cell biology. https://doi.org/10.1083/jcb.122.3.553
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
