The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The kinesin-like protein KLP61F is essential for mitosis in Drosophila.
Open accessAbstract
We report here that disruption of a recently discovered kinesin-like protein in Drosophila melanogaster, KLP61F, results in a mitotic mutation lethal to the organism. We show that in the absence of KLP61F function, spindle poles fail to separate, resulting in the formation of monopolar mitotic spindles. The resulting phenotype of metaphase arrest with polyploid cells is reminiscent of that seen in the fungal bimC and cut7 mutations, where it has also been shown that spindle pole bodies are not segregated. KLP61F is specifically expressed in proliferating tissues during embryonic and larval development, consistent with a primary role in cell division. The structural and functional homology of the KLP61F, bimC, cut7, and Eg5 kinesin-like proteins demonstrates the existence of a conserved family of kinesin-like molecules important for spindle pole separation and mitotic spindle dynamics.
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Cites
Predicting coiled coils from protein sequences.
Lupas, A., Van Dyke, M., & Stock, J. (1991) · Science · doi:10.1126/science.252.5009.1162 · Cited by 3,953
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
VALE, R., REESE, T., & SHEETZ, M. (1985) · Cell · doi:10.1016/s0092-8674(85)80099-4 · Cited by 1,993 · cited 1×
“The matriarch of the kinesin superfamily (kinesin) was discovered in squid axoplasm and as such, is likely to function in axonal transport (Allen et al., 1985; Brady, 1985; Vale et al., 1985).”
BackgroundSaxton, W. M., Hicks, J., Goldstein, L. S. B., & Raff, E. C. (1991) · Cell · doi:10.1016/0092-8674(91)90264-y · Cited by 201
Cited by
Blangy, A., Lane, H. A., d'Hérin, P., Harper, M., Kress, M., & Niggt, E. A. (1995) · Cell · doi:10.1016/0092-8674(95)90142-6 · Cited by 952
Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
Glover, D. M., Leibowitz, M. H., McLean, D. A., & Parry, H. (1995) · Cell · doi:10.1016/0092-8674(95)90374-7 · Cited by 836
Kapoor, T. M., Mayer, T. U., Coughlin, M. L., & Mitchison, T. J. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.5.975 · Cited by 717
The design plan of kinesin motors
Vale, R. D., & Fletterick, R. J. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.745 · Cited by 474
Walczak, C. E., Vernos, I., Mitchison, T. J., Karsenti, E., & Heald, R. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00370-3 · Cited by 396
Metadata
- Authors
- Heck, M. M., Pereira, A., Pesavento, P., Yannoni, Y., Spradling, A. C., & Goldstein, L. S.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1993-11-01
- Volume
- 123
- Issue
- 3
- Pages
- 665-679
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2101176165
- Cited by
- 286
- References
- 3
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Heck, M. M., Pereira, A., Pesavento, P., Yannoni, Y., Spradling, A. C., & Goldstein, L. S. (1993). The kinesin-like protein KLP61F is essential for mitosis in Drosophila. The Journal of cell biology. https://doi.org/10.1083/jcb.123.3.665
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