The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization.
Open accessAbstract
Human adenovirus type 2 (Ad2) enters host cells by receptor-mediated endocytosis, an event mediated by the virus penton base binding to cell surface integrins alpha v beta 3 and alpha v beta 5. While both alpha v integrins promote virus internalization, alpha v beta 5 is involved in the subsequent event of membrane permeabilization. Cells transfected with the beta 5 or beta 3 subunit, expressing either alpha v beta 5 and alpha v beta 3, respectively, were capable of supporting Ad2 infection to varying degrees. In this case, cells expressing alpha v beta 5 were significantly more susceptible to Ad2-induced membrane permeabilization, as well as to Ad2 infection, than cells expressing alpha v beta 3. Adenovirus-mediated gene delivery was also more efficient in cells expressing alpha v beta 5. These results suggest that the interaction of alpha v beta 5 with Ad2 penton base facilitates the subsequent step of virus penetration into the cell. These studies provide evidence for the involvement of a cellular receptor in virus-mediated membrane permeabilization and suggest a novel biological role for integrin alpha v beta 5 in the infectious pathway of a human adenovirus.
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Cites
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Fechner, H., Haack, A., Wang, H., Wang, X., Eizema, K., Pauschinger, M., Schoemaker, R. G., van Veghel, R., Houtsmuller, A. B., Schultheiss, H.-P., et al. (1999) · Gene Therapy · doi:10.1038/sj.gt.3301030 · Cited by 310
The role of the nuclear pore complex in adenovirus DNA entry
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Dynein- and microtubule-mediated translocation of adenovirus serotype 5 occurs after endosomal lysis
Leopold, P. L., Kreitzer, G., Miyazawa, N., Rempel, S., Pfister, K. K., Rodriguez-Boulan, E., & Crystal, R. G. (2000) · Human Gene Therapy · doi:10.1089/10430340050016238 · Cited by 254
Metadata
- Authors
- Wickham, T. J., Filardo, E. J., Cheresh, D. A., & Nemerow, G. R.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1994-10-01
- Volume
- 127
- Issue
- 1
- Pages
- 257-264
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2140362030
- Cited by
- 417
- References
- 31
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Wickham, T. J., Filardo, E. J., Cheresh, D. A., & Nemerow, G. R. (1994). Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization. The Journal of cell biology. https://doi.org/10.1083/jcb.127.1.257
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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