The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Adenovirus-Mediated Transfer of a Recombinant α1-Antitrypsin Gene to the Lung Epithelium in Vivo
Abstract
The respiratory epithelium is a potential site for somatic gene therapy for the common hereditary disorders α1-antitrypsin (α1AT) deficiency and cystic fibrosis. A replication-deficient adenoviral vector (Ad-α1AT) containing an adenovirus major late promoter and a recombinant human α1AT gene was used to infect epithelial cells of the cotton rat respiratory tract in vitro and in vivo. Freshly isolated tracheobronchial epithelial cells infected with Ad-α1AT contained human α1AT messenger RNA transcripts and synthesized and secreted human α1AT. After in vivo intratracheal administration of Ad-α1AT to these rats, human α1AT messenger RNA was observed in the respiratory epithelium, human α1AT was synthesized and secreted by lung tissue, and human α1AT was detected in the epithelial lining fluid for at least 1 week.
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Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
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Identification of the Cystic Fibrosis Gene: Genetic Analysis
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Cited by
Viral vector platforms within the gene therapy landscape
Bulcha, J. T., Wang, Y., Ma, H., Tai, P. W. L., & Gao, G. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00487-6 · Cited by 1,404
Polyamidoamine cascade polymers mediate efficient transfection of cells in culture
Haensler, J., & Szoka, F. C. (1993) · Bioconjugate Chemistry · doi:10.1021/bc00023a012 · Cited by 1,207
Widespread long-term gene transfer to mouse skeletal muscles and heart.
Stratford-Perricaudet, L. D., Makeh, I., Perricaudet, M., & Briand, P. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115902 · Cited by 580
Self-citationPackaging capacity and stability of human adenovirus type 5 vectors
Bett, A. J., Prevec, L., & Graham, F. L. (1993) · Journal of Virology · doi:10.1128/jvi.67.10.5911-5921.1993 · Cited by 472
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Metadata
- Authors
- Rosenfeld, M. A., Siegfried, W., Yoshimura, K., Yoneyama, K., Fukayama, M., Stier, L. E., Pääkkö, P. K., Gilardi, P., Stratford-Perricaudet, L. D., Perricaudet, M., Jallat, S., Pavirani, A., Lecocq, J.-P., & Crystal, R. G.
- Venue
- Science
- Published
- 1991-04-19
- Volume
- 252
- Issue
- 5004
- Pages
- 431-434
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1980401440
- Cited by
- 737
- References
- 3
- FWCI
- 34.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rosenfeld, M. A., Siegfried, W., Yoshimura, K., Yoneyama, K., Fukayama, M., Stier, L. E., Pääkkö, P. K., Gilardi, P., Stratford-Perricaudet, L. D., Perricaudet, M., Jallat, S., Pavirani, A., Lecocq, J.-P., & Crystal, R. G. (1991). Adenovirus-Mediated Transfer of a Recombinant α1-Antitrypsin Gene to the Lung Epithelium in Vivo. Science. https://doi.org/10.1126/science.2017680
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
