The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin.
Open accessAbstract
Neutrophils roll on P-selectin expressed by activated platelets or endothelial cells under the shear stresses in the microcirculation. P-selectin glycoprotein ligand-1 (PSGL-1) is a high affinity ligand for P-selectin on myeloid cells. However, it has not been demonstrated that PSGL-1 contributes to the rolling of neutrophils on P-selectin. We developed two IgG mAbs, PL1 and PL2, that appear to recognize protein-dependent epitopes on human PSGL-1. The mAbs bound to PSGL-1 on all leukocytes as well as on heterologous cells transfected with PSGL-1 cDNA. PL1, but not PL2, blocked binding of 125-I-PSGL-1 to immobilized P-selectin, binding of fluid-phase P-selectin to myeloid and lymphoid leukocytes, adhesion of neutrophils to immobilized P-selectin under static conditions, and rolling of neutrophils on P-selectin-expressing CHO cells under a range of shear stresses. PSGL-1 was localized to microvilli on neutrophils, a topography that may facilitate its adhesive function. These data indicate that (a) PSGL-1 accounts for the high affinity binding sites for P-selectin on leukocytes, and (b) PSGL-1 must interact with P-selectin in order for neutrophils to roll on P-selectin at physiological shear stresses.
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Cites
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Cited by
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Metadata
- Authors
- Moore, K. L., Patel, K. D., Bruehl, R. E., Li, F., Johnson, D. A., Lichenstein, H. S., Cummings, R. D., Bainton, D. F., & McEver, R. P.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1995-02-15
- Volume
- 128
- Issue
- 4
- Pages
- 661-671
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2122028809
- Cited by
- 710
- References
- 52
- FWCI
- 15.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Moore, K. L., Patel, K. D., Bruehl, R. E., Li, F., Johnson, D. A., Lichenstein, H. S., Cummings, R. D., Bainton, D. F., & McEver, R. P. (1995). P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin. The Journal of cell biology. https://doi.org/10.1083/jcb.128.4.661
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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