Cited by 402Neutrophil, Myeloperoxidase and Oxidative MechanismsAntimicrobial Resistance in StaphylococcusInflammation biomarkers and pathways

Neutrophils in innate host defense against Staphylococcus aureus infections

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Rigby, Kevin M., DeLeo, Frank R.·2012·Seminars in Immunopathology

Abstract

Staphylococcus aureus has been an important human pathogen throughout history and is currently a leading cause of bacterial infections worldwide. S. aureus has the unique ability to cause a continuum of diseases, ranging from minor skin infections to fatal necrotizing pneumonia. Moreover, the emergence of highly virulent, drug-resistant strains such as methicillin-resistant S. aureus in both healthcare and community settings is a major therapeutic concern. Neutrophils are the most prominent cellular component of the innate immune system and provide an essential primary defense against bacterial pathogens such as S. aureus. Neutrophils are rapidly recruited to sites of infection where they bind and ingest invading S. aureus, and this process triggers potent oxidative and non-oxidative antimicrobial killing mechanisms that serve to limit pathogen survival and dissemination. S. aureus has evolved numerous mechanisms to evade host defense strategies employed by neutrophils, including the ability to modulate normal neutrophil turnover, a process critical to the resolution of acute inflammation. Here we provide an overview of the role of neutrophils in host defense against bacterial pathogens and discuss strategies employed by S. aureus to circumvent neutrophil function.

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Authors
Rigby, K. M., & DeLeo, F. R.
Affiliations
National Institutes of Health (US)
Corresponding author
DeLeo, Frank R.
Venue
Seminars in Immunopathology
Published
2011-11-12
Volume
34
Issue
2
Pages
237-259
ISSN
  • 1863-2297 (ISSN-L)
  • 1863-2300
OpenAlex
W1990621187
Cited by
400
References
311
Citations by year
2026: 17 · 2025: 20 · 2024: 25 · 2023: 31 · 2022: 29 · 2021: 20 · 2020: 22 · 2019: 33 · 2018: 30 · 2017: 28 · 2016: 30 · 2015: 31 · 2014: 40 · 2013: 36 · 2012: 8
FWCI
2.41
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Seminars in Immunopathology (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords
neutrophils, Staphylococcus aureus, innate immunity, host defense, methicillin-resistant Staphylococcus aureus, bacterial virulence, neutrophil turnover, oxidative killing, necrotizing pneumonia, skin infections
MeSH terms
Animals, Anti-Infective Agents, Humans, Immunity, Innate, Neutrophils, Staphylococcal Infections, Staphylococcus aureus, Virulence, Host-Pathogen Interactions, Methicillin-Resistant Staphylococcus aureus, Immune Evasion

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