The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells.
Open accessAbstract
Studies on the molecular mechanisms underlying neuronal differentiation are frequently performed using cell lines established from neuroblastomas. In this study we have used mouse N1E-115 neuroblastoma cells that undergo neuronal differentiation in response to DMSO. During differentiation, cyclin-dependent kinase (cdk) activities decline and phosphorylation of the retinoblastoma gene product (pRb) is lost, leading to the appearance of a pRb-containing E2F DNA-binding complex. The loss of cdk2 activity is due to a decrease in cdk2 abundance whereas loss of cdk4 activity is caused by strong association with the cdk inhibitor (CKI) p27KIP1 and concurrent loss of cdk4 phosphorylation. Moreover, neuronal differentiation can be induced by overexpression of p27KIP1 or pRb, suggesting that inhibition of cdk activity leading to loss of pRb phosphorylation, is the major determinant for neuronal differentiation.
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Cites
Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein
Lee, J. E., Hollenberg, S. M., Snider, L., Turner, D. L., Lipnick, N., & Weintraub, H. (1995) · Science · doi:10.1126/science.7754368 · Cited by 1,023
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Cell cycle dependent regulation of phosphorylation of the human retinoblastoma gene product
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Cited by
Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27
Kiyokawa, H., Kineman, R. D., Manova-Todorova, K. O., Soares, V. C., Hoffman, E. S., Ono, M., Khanam, D., Hayday, A. C., Frohman, L. A., & Koff, A. (1996) · Cell · doi:10.1016/s0092-8674(00)81238-6 · Cited by 1,251
p27Kip1 links cell proliferation to morphogenesis in the developing organ of Corti
Chen, P., & Segil, N. (1999) · Development · doi:10.1242/dev.126.8.1581 · Cited by 555
The Developmental Biology of Brain Tumors
Wechsler-Reya, R., & Scott, M. P. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.385 · Cited by 462
Stem cell repopulation efficiency but not pool size is governed by p27kip1
Cheng, T., Rodrigues, N., Dombkowski, D., Stier, S., & Scadden, D. T. (2000) · Nature Medicine · doi:10.1038/81335 · Cited by 347
Blain, S. W., Montalvo, E., & Massagué, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25863 · Cited by 279
Metadata
- Authors
- Kranenburg, O., Scharnhorst, V, Van der Eb, A. J., & Zantema, A.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1995-10-01
- Volume
- 131
- Issue
- 1
- Pages
- 227-234
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2075280050
- Cited by
- 166
- References
- 4
- FWCI
- 13.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Kranenburg, O., Scharnhorst, V, Van der Eb, A. J., & Zantema, A. (1995). Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells. The Journal of cell biology. https://doi.org/10.1083/jcb.131.1.227
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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