The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
The function of intermediate filaments in cell shape and cytoskeletal integrity.
Open accessAbstract
This study describes the development and use of a specific method for disassembling intermediate filament (IF) networks in living cells. It takes advantage of the disruptive effects of mimetic peptides derived from the amino acid sequence of the helix initiation 1A domain of IF protein chains. The results demonstrate that at 1:1 molar ratios, these peptides disassemble vimentin IF into small oligomeric complexes and monomers within 30 min at room temperature in vitro. Upon microinjection into cultured fibroblasts, these same peptides induce the rapid disassembly of IF networks. The disassembly process is accompanied by a dramatic alteration in cell shape and the destabilization of microtubule and actin-stress fiber networks. These changes in cell shape and IF assembly states are reversible. The results are discussed with respect to the roles of IF in cell shape and the maintenance of the integrity and mechanical properties of the cytoplasm, as well as the stability of the other major cytoskeletal systems.
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Cites
Mechanotransduction Across the Cell Surface and Through the Cytoskeleton
Wang, N., Butler, J. P., & Ingber, D. E. (1993) · Science · doi:10.1126/science.7684161 · Cited by 3,003
FORMATION OF ARROWHEAD COMPLEXES WITH HEAVY MEROMYOSIN IN A VARIETY OF CELL TYPES
Ishikawa, H., Bischoff, R., & Holtzer, H. (1969) · The Journal of Cell Biology · doi:10.1083/jcb.43.2.312 · Cited by 967
Viscoelastic properties of vimentin compared with other filamentous biopolymer networks.
Janmey, P. A., Euteneuer, U., Traub, P., & Schliwa, M. (1991) · The Journal of cell biology · doi:10.1083/jcb.113.1.155 · Cited by 721
Mice lacking vimentin develop and reproduce without an obvious phenotype
Colucci-Guyon, E., Portier, M.-M., Dunia, I., Paulin, D., Pournin, S., & Babinet, C. (1994) · Cell · doi:10.1016/0092-8674(94)90553-3 · Cited by 598
THE ROLE OF THREE CYTOPLASMIC FIBERS IN BHK-21 CELL MOTILITY
Goldman, R. D. (1971) · The Journal of Cell Biology · doi:10.1083/jcb.51.3.752 · Cited by 446
Self-citationWelch, W. J., & Suhan, J. P. (1985) · The Journal of cell biology · doi:10.1083/jcb.101.4.1198 · Cited by 427
Borisy, G. G., Marcum, J. M., Olmsted, J. B., Murphy, D. B., & Johnson, K. A. (1975) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1975.tb19196.x · Cited by 423
A mutation in the conserved helix termination peptide of keratin 5 in hereditary skin blistering
Lane, E. B., Rugg, E. L., Navsaria, H., Leigh, I. M., Heagerty, A. H. M., Ishida-Yamamoto, A., & Eady, R. A. J. (1992) · Nature · doi:10.1038/356244a0 · Cited by 404
Chou, Y.-H., Bischoff, J. R., Beach, D., & Goldman, R. D. (1990) · Cell · doi:10.1016/0092-8674(90)90384-q · Cited by 330
Self-citationIntermediate filament proteins in the developing chick spinal cord
Tapscott, S. J., Bennett, G. S., Toyama, Y., Kleinbart, F., & Holtzer, H. (1981) · Developmental Biology · doi:10.1016/0012-1606(81)90313-4 · Cited by 313
Cited by
Cytoskeletal regulation of pulmonary vascular permeability
Dudek, S. M., & Garcia, J. G. N. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.4.1487 · Cited by 985
Mendez, M. G., Kojima, S., & Goldman, R. D. (2010) · The FASEB Journal · doi:10.1096/fj.09-151639 · Cited by 939
Self-citationIntermediate filaments: from cell architecture to nanomechanics
Herrmann, H., Bär, H., Kreplak, L., Strelkov, S. V., & Aebi, U. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2197 · Cited by 698
Intermediate filaments mediate cytoskeletal crosstalk
Chang, L., & Goldman, R. D. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1438 · Cited by 386
Self-citationIntermediate filament interactions can be altered by HSP27 and αB-crystallin
Perng, M. D., Cairns, L., van den Ijssel, P., Prescott, A., Hutcheson, A. M., & Quinlan, R. A. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.13.2099 · Cited by 358
Metadata
- Authors
- Goldman, R. D., Khuon, S., Chou, Y. H., Opal, P., & Steinert, P. M.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1996-08-15
- Volume
- 134
- Issue
- 4
- Pages
- 971-983
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2126048177
- Cited by
- 373
- References
- 60
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Goldman, R. D., Khuon, S., Chou, Y. H., Opal, P., & Steinert, P. M. (1996). The function of intermediate filaments in cell shape and cytoskeletal integrity. The Journal of cell biology. https://doi.org/10.1083/jcb.134.4.971
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
