The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex.
Open accessAbstract
Mammalian telomeres are composed of long arrays of TTAGGG repeats complexed with the TTAGGG repeat binding factor, TRF. Biochemical and ultrastructural data presented here show that the telomeric DNA and TRF colocalize in individual, condensed structures in the nuclear matrix. Telomeric TTAGGG repeats were found to carry an array of nuclear matrix attachment sites occurring at a frequency of at least one per kb. The nuclear matrix association of the telomeric arrays extended over large domains of up to 20-30 kb, encompassing the entire length of most mammalian telomeres. TRF protein and telomeric DNA cofractionated in nuclear matrix preparations and colocalized in discrete, condensed sites throughout the nuclear volume. FISH analysis indicated that TRF is an integral component of the telomeric complex and that the presence of TRF on telomeric DNA correlates with the compact configuration of telomeres and their association with the nuclear matrix. Biochemical fractionation of TRF and telomeric DNA did not reveal an interaction with the nuclear lamina. Furthermore, ultrastructural analysis indicated that the mammalian telomeric complex occupied sites throughout the nuclear volume, arguing against a role for the nuclear envelope in telomere function during interphase. These results are consistent with the view that mammalian telomeres form nuclear matrix-associated, TRF-containing higher order complexes at dispersed sites throughout the nuclear volume.
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Citations
Cites
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091
Telomeres shorten during ageing of human fibroblasts
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The RNA Component of Human Telomerase
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Telomere reduction in human colorectal carcinoma and with ageing
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“In agreement, telomerase is frequently activated in human and mouse tumors and restoration of telomere length is correlated with immortalization of human cells in vitro (Counter et al., 1992, 1994a, b; Kim et al., 1994; Blasco et al., 1996; Broccoli et al., 1996a).”
BackgroundHypervariable ultra-long telomeres in mice
Kipling, D., & Cooke, H. J. (1990) · Nature · doi:10.1038/347400a0 · Cited by 614
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Cited by
Mammalian Telomeres End in a Large Duplex Loop
Griffith, J. D., Comeau, L., Rosenfield, S., Stansel, R. M., Bianchi, A., Moss, H., & de Lange, T. (1999) · Cell · doi:10.1016/s0092-8674(00)80760-6 · Cited by 2,447
Control of telomere length by the human telomeric protein TRF1
van Steensel, B., & de Lange, T. (1997) · Nature · doi:10.1038/385740a0 · Cited by 1,219
Human telomeres contain two distinct Myb–related proteins, TRF1 and TRF2
Broccoli, D., Smogorzewska, A., Chong, L., & de Lange, T. (1997) · Nature Genetics · doi:10.1038/ng1097-231 · Cited by 926
Self-citationAlternative lengthening of telomeres in mammalian cells
Henson, J. D., Neumann, A. A., Yeager, T. R., & Reddel, R. R. (2002) · Oncogene · doi:10.1038/sj.onc.1205058 · Cited by 664
THE LEPTOTENE-ZYGOTENE TRANSITION OF MEIOSIS
Zickler, D., & Kleckner, N. (1998) · Annual Review of Genetics · doi:10.1146/annurev.genet.32.1.619 · Cited by 531
Metadata
- Authors
- Ludérus, M. E., van Steensel, B., Chong, L., Sibon, O. C., Cremers, F. F., & de Lange, T.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1996-11-15
- Volume
- 135
- Issue
- 4
- Pages
- 867-881
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2136420353
- Cited by
- 232
- References
- 14
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Ludérus, M. E., van Steensel, B., Chong, L., Sibon, O. C., Cremers, F. F., & de Lange, T. (1996). Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex. The Journal of cell biology. https://doi.org/10.1083/jcb.135.4.867
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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