The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Active and inactive genes localize preferentially in the periphery of chromosome territories.
Open accessAbstract
The intranuclear position of a set of genes was analyzed with respect to the territories occupied by the whole chromosomes in which these genes are localized. Genes and their respective chromosome territories were simultaneously visualized in three-dimensionally preserved nuclei applying dual color fluorescence in situ hybridization. Three coding (DMD, MYH7, and HBB) and two noncoding sequences (D1Z2 and an anonymous sequence) were analyzed in four different cell types, including cells where DMD and MYH7 are actively transcribed. Spatial analysis by confocal laser scanning microscopy revealed that the genes are preferentially located in the periphery of chromosome territories. This positioning was independent from the activity of the genes. In contrast, the non-expressed anonymous fragment was found randomly distributed or localized preferentially in the interior of the corresponding chromosome territory. Furthermore, the distribution of the analyzed genes within the territorial peripheries was found to be highly characteristic for each gene, and, again, independent from its expression. The impact of these findings with regard to the three-dimensional arrangement of the linear DNA string within chromosome territories, as well as with respect to a putative nuclear subcompartment confining gene expression, are discussed.
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Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Saiki, R. K., Scharf, S., Faloona, F., Mullis, K. B., Horn, G. T., Erlich, H. A., & Arnheim, N. (1985) · Science · doi:10.1126/science.2999980 · Cited by 8,956
Agresti, A. (2002) · Wiley Series in Probability and Statistics · doi:10.1002/0471249688 · Cited by 6,746
High-Resolution Mapping of Human Chromosome 11 by in Situ Hybridization with Cosmid Clones
Lichter, P., Tang, C.-J. C., Call, K., Hermanson, G., Evans, G. A., Housman, D., & Ward, D. C. (1990) · Science · doi:10.1126/science.2294592 · Cited by 1,331
Self-citationPinkel, D., Landegent, J., Collins, C., Fuscoe, J., Segraves, R., Lucas, J., & Gray, J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.9138 · Cited by 1,330
Gunning, P., Ponte, P., Okayama, H., Engel, J., Blau, H., & Kedes, L. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.5.787-795.1983 · Cited by 1,196
Lichter, P., Cremer, T., Borden, J., Manuelidis, L., & Ward, D. C. (1988) · Human Genetics · doi:10.1007/bf01790090 · Cited by 1,160
Self-citationVisualization of focal sites of transcription within human nuclei.
Jackson, D. A., Hassan, A. B., Errington, R. J., & Cook, P. R. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05747.x · Cited by 663
Blobel, G. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8527 · Cited by 602
Cremer, T., Lichter, P., Borden, J., Ward, D. C., & Manuelidis, L. (1988) · Human Genetics · doi:10.1007/bf01790091 · Cited by 550
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Cited by
Nuclear organization of the genome and the potential for gene regulation
Fraser, P., & Bickmore, W. (2007) · Nature · doi:10.1038/nature05916 · Cited by 734
Chambeyron, S., & Bickmore, W. A. (2004) · Genes & Development · doi:10.1101/gad.292104 · Cited by 623
Volpi, E. V., Chevret, E., Jones, T., Vatcheva, R., Williamson, J., Beck, S., Campbell, R. D., Goldsworthy, M., Powis, S. H., Ragoussis, J., et al. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.9.1565 · Cited by 441
Experimental observations of a nuclear matrix
Nickerson, J. A. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.3.463 · Cited by 313
Chromosome painting: a useful art
Ried, T. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.10.1619 · Cited by 154
Metadata
- Authors
- Kurz, A., Lampel, S., Nickolenko, J. E., Bradl, J., Benner, A., Zirbel, R. M., Cremer, T., & Lichter, P.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1996-12-01
- Volume
- 135
- Issue
- 5
- Pages
- 1195-1205
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2162633623
- Cited by
- 265
- References
- 55
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- green
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- Kurz, A., Lampel, S., Nickolenko, J. E., Bradl, J., Benner, A., Zirbel, R. M., Cremer, T., & Lichter, P. (1996). Active and inactive genes localize preferentially in the periphery of chromosome territories. The Journal of cell biology. https://doi.org/10.1083/jcb.135.5.1195
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
