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Cited by 306

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

CELL PROLIFERATION AND SPECIALIZATION DURING ENDOCHONDRAL OSTEOGENESIS IN YOUNG RATS

Open access
Young, Richard W.·1962·The Journal of Cell Biology
DOI 10.1083/jcb.14.3.357
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Abstract

Endochondral osteogenesis was studied autoradiographically in ribs and tibiae of 32 Long-Evans rats injected with 1 µc/gm H3-thymidine at 6 days of age and sacrificed at intervals between 1 hour and 2 weeks later. Proliferation and specialization of bone cells were studied by analyses of (a) the percentage of mitoses which were labeled, (b) the percentage of labeled nuclei in bone cells, and (c) grain counts. The following conclusions were derived: The various types of bone cells represent different functional states of the same cell. Cell division is usually restricted to cells in the morphologically unspecialized "osteoprogenitor" state. Specialized bone cells arise by modulation of osteoprogenitor cells. The average cell generation time is shortest in the metaphysis, longest in the periosteum, and intermediate in the endosteum. The average duration of DNA synthesis is relatively constant (about 8 hours). With increasing length of generation time there is a slight increase in G2 + mitosis, but the major change is a lengthening of G1. After dividing, cells in the osteoprogenitor state may remain within the progenitor pool or undergo modulation of cell type, specializing as osteoblasts or becoming incorporated in osteoclasts.

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Metadata

Authors
Young, R. W.
Venue
The Journal of Cell Biology
Publisher
Rockefeller University Press
Published
1962-09-01
Volume
14
Issue
3
Pages
357-370
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
DOI
10.1083/jcb.14.3.357
OpenAlex
W2028011522
Cited by
306
References
10
FWCI
4.88
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: CELL PROLIFERATION AND SPECIALIZATION DURING ENDOCHONDRAL OSTEOGENESIS IN YOUNG RATS. https://app.cochat.ai/papers/10.1083/jcb.14.3.357
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Young, R. W. (1962). CELL PROLIFERATION AND SPECIALIZATION DURING ENDOCHONDRAL OSTEOGENESIS IN YOUNG RATS. The Journal of Cell Biology. https://doi.org/10.1083/jcb.14.3.357

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.