The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Actinin-4, a Novel Actin-bundling Protein Associated with Cell Motility and Cancer Invasion
Open accessAbstract
Regulation of the actin cytoskeleton may play a crucial role in cell motility and cancer invasion. We have produced a monoclonal antibody (NCC- Lu-632, IgM, k) reactive with an antigenic protein that is upregulated upon enhanced cell movement. The cDNA for the antigen molecule was found to encode a novel isoform of nonmuscle α-actinin. This isoform (designated actinin-4) was concentrated in the cytoplasm where cells were sharply extended and in cells migrating and located at the edge of cell clusters, but was absent from focal adhesion plaques or adherens junctions, where the classic isoform (actinin-1) was concentrated. Actinin-4 shifted steadily from the cytoplasm to the nucleus upon inhibition of phosphatidylinositol 3 kinase or actin depolymerization. The cytoplasmic localization of actinin-4 was closely associated with an infiltrative histological phenotype and correlated significantly with a poorer prognosis in 61 cases of breast cancer. These findings suggest that cytoplasmic actinin-4 regulates the actin cytoskeleton and increases cellular motility and that its inactivation by transfer to the nucleus abolishes the metastatic potential of human cancers.
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Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Cell Migration: A Physically Integrated Molecular Process
Lauffenburger, D. A., & Horwitz, A. F. (1996) · Cell · doi:10.1016/s0092-8674(00)81280-5 · Cited by 3,915
Cited by
Mutations in ACTN4, encoding α-actinin-4, cause familial focal segmental glomerulosclerosis
Kaplan, J. M., H Kim, S., North, K. N., Rennke, H., A Correia, L., Tong, H.-Q., Mathis, B. J., Rodríguez-Pérez, J.-C., Allen, P. G., Beggs, A. H., et al. (2000) · Nature Genetics · doi:10.1038/73456 · Cited by 1,235
Actin stress fibers – assembly, dynamics and biological roles
Tojkander, S., Gateva, G., & Lappalainen, P. (2012) · Journal of Cell Science · doi:10.1242/jcs.098087 · Cited by 900
α-Actinin-4 drives invasiveness by regulating myosin IIB expression and myosin IIA localization
Barai, A., Mukherjee, A., Das, A., Saxena, N., & Sen, S. (2021) · Journal of Cell Science · doi:10.1242/jcs.258581 · Cited by 23
Metadata
- Authors
- Honda, K., Yamada, T., Endo, R., Ino, Y., Gotoh, M., Tsuda, H., Yamada, Y., Chiba, H., & Hirohashi, S.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1998-03-23
- Volume
- 140
- Issue
- 6
- Pages
- 1383-1393
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2040980668
- Cited by
- 483
- References
- 2
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- green
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