Cell Migration: A Physically Integrated Molecular Process
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Cell-substrate adhesions affect migration speed, with low or high adhesive strength slowing down migration, while intermediate adhesive strength enables optimal migration.
“Cell-substrate adhesions affect migration speed, with low or high adhesive strength slowing down migration, while intermediate adhesive strength enables optimal migration47.”
From PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages (2021) · cites this paper as [47]
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Ji, H., Wang, J., Nika, H., Hawke, D., Keezer, S., Ge, Q., Fang, B., Fang, X., Fang, D., Litchfield, D. W., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.034 · Cited by 270 · see citing works
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Astrof, S., Crowley, D., & Hynes, R. O. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.07.005 · Cited by 136 · see citing works
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Easley, C. A., Brown, C. M., Horwitz, A. F., & Tombes, R. M. (2008) · Cell Motility · doi:10.1002/cm.20294 · Cited by 56 · see citing works
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Obst, J., Hall-Roberts, H. L., Smith, T. B., Kreuzer, M., Magno, L., Di Daniel, E., Davis, J. B., & Mead, E. (2021) · Scientific Reports · doi:10.1038/s41598-021-96144-7 · Cited by 36 · see citing works
Ernest James Phillips, T., & Maguire, E. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.652593 · Cited by 33 · see citing works
- Authors
- Lauffenburger, D. A., & Horwitz, A. F.
- Affiliations
- Massachusetts Institute of Technology (US)
- University of Illinois Urbana-Champaign (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-02
- Volume
- 84
- Issue
- 3
- Pages
- 359-369
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1967265143
- Cited by
- 3,915
- References
- 0
- Citations by year
- 2026: 41 · 2025: 60 · 2024: 52 · 2023: 79 · 2022: 83 · 2021: 77 · 2020: 107 · 2019: 117 · 2018: 108 · 2017: 131 · 2016: 140 · 2015: 141 · 2014: 189 · 2013: 163 · 2012: 187
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM 53905, GM 23244, R01GM053905)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- cell migration, mechanobiology, embryonic morphogenesis, leukocyte migration, wound healing, metastasis, tissue engineering, biomaterial scaffolds
- MeSH terms
- Actins, Animals, Biophysics, Cell Adhesion, Cell Membrane, Cell Movement, Humans, Signal Transduction, Cell Polarity, Biophysical Phenomena
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