Kinesin Light Chains Are Essential for Axonal Transport in Drosophila

Gindhart, Joseph G., Desai, Chand J., Beushausen, Sven, Zinn, Kai, Goldstein, Lawrence S.B.·1998·The Journal of Cell Biology

Cited by (178)

Items 101–178 of 178

  1. Alternatively Spliced Products of the Human Kinesin Light Chain 1 (KNS2) Gene
    Amy E. McCart Reed, Donna Mahony, Joseph A. Rothnagel · 2003 · Traffic
  2. In-vivo evidence for the disruption of Rab11 vesicle transport by loss of huntingtin
    Derek Power, Shruthi Srinivasan, Shermali Gunawardena · 2012 · Neuroreport
  3. Distinct functional roles of cytoplasmic dynein defined by the intermediate chain isoforms
    K. Kevin Pfister · 2015 · Experimental Cell Research
  4. Rat kinesin light chain 3 associates with spermatid mitochondria
    Ying Zhang, Richard J. Oko, Frans A. van der Hoorn · 2004 · Developmental Biology
  5. The auto-inhibitory domain and ATP-independent microtubule-binding region of Kinesin heavy chain are major functional domains for transport in theDrosophilagermline
    Lucy S. Williams, Sujoy Ganguly, Philippe Loiseau, Bing Fu Ng, Isabel M. Palacios · 2013 · Development
  6. The Non-amyloidal Component Region of α-Synuclein Is Important for α-Synuclein Transport Within Axons
    Eric Nathaniel Anderson, Delnessaw Hirpa, Kan Hong Zheng, Rupkatha Banerjee, Shermali Gunawardena · 2020 · Frontiers in Cellular Neuroscience
  7. Association of Kinesin Light Chain with Outer Dense Fibers in a Microtubule-independent Fashion
    Bhupinder Bhullar, Ying Zhang, Albert Junco, Richard J. Oko, Frans A. van der Hoorn · 2003 · Journal of Biological Chemistry
  8. Hereditary spastic paraplegia with recessive trait caused by mutation in KLC4 gene
    Fatih Bayraklı, Hatice Gamze Poyrazoğlu, Şirin Yüksel, Cengiz Yakıcıer, Bekir Ergüner, Mahmut Şamil Sağıroğlu, Betül Yücetürk, Buğra Özer, Selim Doganay, Bahattin Tanrıkulu et al. · 2015 · Journal of Human Genetics
  9. The Gene for the Intermediate Chain Subunit of Cytoplasmic Dynein Is Essential in Drosophila
    Kristin L.M. Boylan, Thomas S. Hays · 2002 · Genetics
  10. Disruption of Axonal Transport Perturbs Bone Morphogenetic Protein (BMP) - Signaling and Contributes to Synaptic Abnormalities in Two Neurodegenerative Diseases
    Min‐Jung Kang, Timothy J. Hansen, Monique Mickiewicz, Tadeusz J. Kaczynski, Samantha Fye, Shermali Gunawardena · 2014 · PLoS ONE
  11. Drosophila Atlastin in motor neurons is required for locomotion and presynaptic function
    Cristian De Gregorio, Ricardo Delgado, Andrés Ibacache, Jimena A. Sierralta, Andrés Couve · 2017 · Journal of Cell Science
  12. KIF5C, a novel neuronal kinesin enriched in motor neurons
    Yoshimitsu Kanai · 2000 · Neuroscience Research
  13. Kinesin: the tail unfolds
    Robert Anthony Cross, Jonathan M. Scholey · 1999 · Nature Cell Biology
  14. Kinesin-Ii, Coming and Going
    Douglas G. Cole · 1999 · The Journal of Cell Biology
  15. Mechanisms controlling the trafficking, localization, and abundance of presynaptic Ca2+ channels
    Karen L Cunningham, J. Troy Littleton · 2023 · Frontiers in Molecular Neuroscience
  16. Abl Tyrosine Kinase and Its Substrate Ena/VASP Have Functional Interactions with Kinesin-1
    MaryAnn Martin, Shawn M. Ahern-Djamali, F. Michael Hoffmann, William M. Saxton · 2005 · Molecular Biology of the Cell
  17. Clonal Tests of Conventional Kinesin Function during Cell Proliferation and Differentiation
    Robert P. Brendza, Kathy B. Sheehan, F. Rudolf Turner, William M. Saxton · 2000 · Molecular Biology of the Cell
  18. A Functional Misexpression Screen Uncovers a Role for Enabled in Progressive Neurodegeneration
    Carolina Rezával, Jimena Berni, Ezequiel Axel Gorostiza, Santiago Werbajh, María Marta Fagilde, Maria P. Fernandez, Esteban J. Beckwith, Ezequiel J. Aranovich, Carmen Alejandra Sabio y García, M. Fernanda Ceriani · 2008 · PLoS ONE
  19. Activation by GDNF of a transcriptional program repressing neurite growth in dorsal root ganglia
    Sten Linnarsson, Åsa Mikaels, Christel Baudet, Patrik Ernfors · 2001 · Proceedings of the National Academy of Sciences
  20. A stop or go switch: glycogen synthase kinase 3β phosphorylation of the kinesin 1 motor domain at Ser314 halts motility without detaching from microtubules
    Rupkatha Banerjee, Piyali Chakraborty, Michael C. Yu, Shermali Gunawardena · 2021 · Development
  21. Phosphoregulation of Kinesins Involved in Long-Range Intracellular Transport
    Diksha Kumari, Krishanu Ray · 2022 · Frontiers in Cell and Developmental Biology
  22. Molecular pathogenesis of peripheral neuropathies: insights from Drosophila models
    Julia Bussmann, Erik Storkebaum · 2017 · Current Opinion in Genetics & Development
  23. Vesicular Axonal Transport is Modified In Vivo by Tau Deletion or Overexpression in Drosophila
    Yasmina Talmat-Amar, Yoan Arribat, Marie‐Laure Parmentier · 2018 · International Journal of Molecular Sciences
  24. The Actin-Binding Protein Capulet Genetically Interacts with the Microtubule Motor Kinesin to Maintain Neuronal Dendrite Homeostasis
    Paul Mark B. Medina, Ryan J. Worthen, Lawrence J. Forsberg, Jay E. Brenman · 2008 · PLoS ONE
  25. Kinesins in the nervous system
    MaryAnn Martin, Daryl D. Hurd, William M. Saxton · 1999 · Cellular and Molecular Life Sciences
  26. KLC4 shapes axon arbors during development and mediates adult behavior
    Elizabeth M. Haynes, Korri H Burnett, Jiaye He, Marcel W Jean-Pierre, Martin Jarzyna, Kevin W. Eliceiri, Jan Huisken, Mary C. Halloran · 2022 · eLife
  27. Unraveling the interplay of kinesin-1, tau, and microtubules in neurodegeneration associated with Alzheimer’s disease
    Siva Sundara Kumar Durairajan, Karthikeyan Selvarasu, Abhay Kumar Singh, Supriti Patnaik, Ashok Iyaswamy, Yogini Jaiswal, Leonard Lamont Williams, Jian‐Dong Huang · 2024 · Frontiers in Cellular Neuroscience
  28. The Overall Conformation of Conventional Kinesins Studied by Small Angle X-ray and Neutron Scattering
    Frank Kozielski, Dmitri I. Svergun, Giuseppe Zaccaı̈, Richard H. Wade, Michel H. J. Koch · 2001 · Journal of Biological Chemistry
  29. Atlas stumbled: Kinesin light chain‐1 variant E triggers a vicious cycle of axonal transport disruption and amyloid‐β generation in Alzheimer's disease
    Kathlyn J. Gan, Takashi Morihara, Michael A Silverman · 2014 · BioEssays
  30. The presenilin loop region is essential for glycogen synthase kinase 3 β (GSK3β) mediated functions on motor proteins during axonal transport
    Rupkatha Banerjee, Zoe Rudloff, Crystal Naylor, Michael C. Yu, Shermali Gunawardena · 2018 · Human Molecular Genetics
  31. A Genetic Screen Based onin VivoRNA Imaging Reveals Centrosome-Independent Mechanisms for LocalizinggurkenTranscripts inDrosophila
    Rippei Hayashi, S. Mark Wainwright, Sophie J. Liddell, Sheena M. Pinchin, Stuart D. Horswell, David Ish‐Horowicz · 2014 · G3 Genes Genomes Genetics
  32. Axonal transport and neurodegenerative disease: vesicle-motor complex formation and their regulation
    Shermali Gunawardena, Eric Nathaniel Anderson, Joseph White · 2014 · Degenerative Neurological and Neuromuscular Disease
  33. Kinesin-1 autoinhibition facilitates the initiation of dynein cargo transport
    Rongde Qiu, Jun Zhang, Xin Xiang · 2022 · The Journal of Cell Biology
  34. The Neural Receptor Protein Tyrosine Phosphatase DPTP69D Is Required During Periods of Axon Outgrowth in Drosophila
    Chand J. Desai, Joy Purdy · 2003 · Genetics
  35. Synaptic dysfunction in disease and following injury in the developing and adult nervous system: Caveats in the choice of therapeutic intervention☆
    T GOULD, Ronald W. Oppenheim · 2007 · Neuroscience & Biobehavioral Reviews
  36. A Unique Role for Endothelial Cell Kinesin Light Chain 1, Variant 1 in Leukocyte Transendothelial Migration
    Bita F. Cyrus, William A. Müller · 2016 · American Journal Of Pathology
  37. Kinesin Light Chain 1 Suppression Impairs Human Embryonic Stem Cell Neural Differentiation and Amyloid Precursor Protein Metabolism
    Rhiannon L. Killian, Jessica D. Flippin, Cheryl M. Herrera, Angels Almenar‐Queralt, Lawrence S.B. Goldstein · 2012 · PLoS ONE
  38. Role of Kinesin Heavy Chain in Crumbs Localization along the Rhabdomere Elongation in Drosophila Photoreceptor
    Garrett P. League, Sang‐Chul Nam · 2011 · PLoS ONE
  39. Dynein catch bond as a mediator of codependent bidirectional cellular transport
    Palka Puri, Nisha Gupta, Sameep Chandel, Supriyo Naskar, Anil Nair, Abhishek Chaudhuri, Mithun K. Mitra, Sudipto Muhuri · 2019 · Physical Review Research
  40. Single Molecular Observation of Self-Regulated Kinesin Motility
    Tomonobu M. Watanabe, Toshio Yanagida, Atsuko Hikikoshi Iwane · 2010 · Biochemistry
  41. Kinesin Delivers
    Peter J. Hollenbeck · 2001 · The Journal of Cell Biology
  42. The Drosophila kinesin‐I associated protein YETI binds both kinesin subunits
    Tiffany Wisniewski, C.L. Tanzi, Joseph G. Gindhart · 2003 · Biology of the Cell
  43. Tau Protein: Function and Pathology
    Hanna Rosenmann, David L Blum, Rakez Kayed, Lars Matthias Ittner · 2012 · International Journal of Alzheimer s Disease
  44. Drosophila Primary Neuronal Cultures as a Useful Cellular Model to Study and Image Axonal Transport
    André Voelzmann, Natalia Sánchez‐Soriano · 2022 · Methods in molecular biology
  45. PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport
    Paraskevi Tziortzouda, Jolien Steyaert, Wendy Scheveneels, Adrià Sicart, Katarina Stoklund Dittlau, Adriana Margarida Barbosa Correia, Thibaut Burg, Arun Pal, Andreas Hermann, Philip Van Damme et al. · 2024 · Acta Neuropathologica
  46. Techniques to Dissect Cellular and Subcellular Function in the Drosophila Nervous System
    Heinrich J. G. Matthies, Kendal S. Broadie · 2003 · Methods in cell biology
  47. Dynamic microtubule organization and mitochondrial transport are regulated by distinct Kinesin-1 pathways
    Anna Melkov, Yasmin Simchoni, Yehonatan Alcalay, Uri Abdu · 2015 · Biology Open
  48. Application of simple photobleaching microscopy techniques for the determination of the balance between anterograde and retrograde axonal transport
    Asparouh I. Iliev, Fred Silvester Wouters · 2006 · Journal of Neuroscience Methods
  49. Spatial and Temporal Characteristics of Normal and Perturbed Vesicle Transport
    Gary J. Iacobucci, Noura Abdel Rahman, Aida Andrades Valtueña, Tapan K. Nayak, Shermali Gunawardena · 2014 · PLoS ONE
  50. Methods to identify and analyze gene products involved in neuronal intracellular transport using Drosophila
    Amanda L. Neisch, Adam W. Avery, James B. Machamer, Min-gang Li, Thomas S. Hays · 2015 · Methods in cell biology
  51. Cytoplasmic Dynein Function Defined by Subunit Composition
    K. Kevin Pfister, Kevin W.‐H. Lo · 2011 · Elsevier eBooks
  52. Characterization of kinesin-like proteins in silkworm posterior silkgland cells
    Qiao Wang, Junlin Teng, Birong Shen, Wei Zhang, Yige Guo, Xiaolei Su, Chuan‐Xi Zhang, Albert Cheung‐Hoi Yu, Jianguo Chen · 2010 · Cell Research
  53. Kinesin-1 promotes centrosome clustering and nuclear migration in the Drosophila oocyte
    Maëlys Loh, Fred Bernard, Antoine Guichet · 2023 · Development
  54. Purification of Kinesin from the Brain
    Sergei A. Kuznetsov, Vladimir I. Gelfand · 2001 · Humana Press eBooks
  55. Loss and gain of motor protein function cause microtubule bundle damage in Drosophila axons
    Yu-Ting Liew, Milli Owens, David M.D. Bailey, William Cairns, Maureece Day, Ella Jones, Sophie McCann, Lydia Lorenzo-Cisneros, Thomas Murphy, Jill Parkin et al. · 2026 · Current Biology
  56. Different Mechanisms Link Gain and Loss of Kinesin Functions to Axonal Degeneration
    Yu-Ting Liew, David M. Bailey, William Cairns, Maureece Day, Federico Dajas‐Bailador, Ella Jones, Sophie McCann, Matthias Landgraf, Lydia Lorenzo-Cisneros, Thomas Murphy et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  57. New cell biological explanations for kinesin-linked axon degeneration
    Yu-Ting Liew, André Voelzmann, Liliana M. Pinho-Correia, Thomas Murphy, Haydn Tortoishell, Jill Parkin, David M. Bailey, Matthias Landgraf, Andreas Prokop · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  58. Causal relationship between tinnitus and 8 psychiatric phenotypes: a Mendelian randomization study
    Tao Guo, Hui Xie · 2025 · European Archives of Psychiatry and Clinical Neuroscience
  59. Consequences of the Novel ALS-Associated KIF5A Variant c.2993-6C > A for Exon 27 Splicing and Axonal Transport of SFPQ
    Ziqi Yu, Jay P. Ross, Daniel L. Rochefort, Boting Li, Kate Bornais, Marvin Chum, Sali M.K. Farhan, Patrick A. Dion, Guy Armand Rouleau · 2026 · Neurology Genetics
  60. Trio analysis in dystonia identifies de novo KLC1 variants in a kinesinopathy with distinct motor and neurodevelopmental features
    Elisa Peirano, Laura O’Regan, Philip Harrer, Ivana Dzinovic, Magda S. Chegkazi, Petra Havránková, Theresa Brunet, Rossella Capolino, Claudia Cesario, Stefania Ferro et al. · 2026 · EBioMedicine
  61. Identification of Kinesin-Associated Proteins
    Lisa C. Lindesmith, Janardan Kumar, Michael P. Sheetz · 2001 · Humana Press eBooks
  62. Drosophila cytoplasmic dynein
    Amanda L. Neisch, Adam W. Avery, Min-gang Li, Thomas S. Hays · 2017 · Elsevier eBooks
  63. Structural Studies on Kinesin-1 Motor Domain and Light Chain from Rattus norvegicus and Neurospora crassa
    Spyridon Mylonas · 2005
  64. Boxing: The Preparticipation Evaluation
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  65. Clustering of the Endoplasmic Reticulum in Aluminum Induced Apoptosis
    Adam Nathan Hertlein · 2003 · Scholars Crossing (Liberty University)
  66. Crosslinking studies on the conventional kinesin of Neurospora crassa
    Katrin Hahlen · 2004 · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München)
  67. Störungen des axonalen Transports bei der hereditären spastischen Spinalparalyse im Drosophila -Modell
    Ärztlicher Direktor, Thomas Gasser · 2011
  68. The β Subunit of Heterotrimeric G Protein Interacts Directly with Kinesin Heavy Chains, Kinesin-I
    Dae‐Hyun Seog · 2010 · Journal of Life Science
  69. Restraint of the Wallenda/DLK MAP Kinase cascade by the Kinesin-3 motor regulates the assembly of synapses
    Jiaxing Li · 2017 · Deep Blue (University of Michigan)
  70. Desvendando as bases moleculares da síndrome SPOAN: deleção em homozigose em região regulatória leva à superexpressão do gene KLC2
    Uirá Souto Melo · 2017
  71. Computational methods for analyzing ngs data to discover clinically relevant mutations
    Bekir Ergüner · 2017 · Sabanci University
  72. Dynein catch bond as a mediator of codependent bidirectional cellular transport
    Palka Puri, Nisha Gupta, Sameep Chandel, Supriyo Naskar, Anil Nair, Abhishek Chaudhuri, Mithun Kumar Mitra, Sudipto Muhuri · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  73. Cytoplasmic dynein function defined by subunit composition
    K. Kevin Pfister · 2017 · Elsevier eBooks
  74. Motor protein disruption critically alters organelle trafficking, NMJ formation, and excitation contraction coupling
    Himanshu Bansal, Tadros A. Hana, Andrew H. Michael, Sevinch U. Kamaridinova, J. Bransford, Kiel G. Ormerod · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  75. Endoplasmic reticulum stress-related genes contribute to lung cancer risk: a multiomics data integration study
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  76. Microtubule curling as an efficient readout to uncover fundamental concepts of axonal cell biology and neurodegeneration
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  77. Genetic evidence for a functional association between Parkinson’s disease proteins leucine-rich repeat kinase 2 and α-synuclein during axonal transport
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  78. Étude de la toxicité neuronale induite par la protéine Tau dans la maladie d’Alzheimer, sur un modèle Invertébré : Drosophila melanogaster
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