Kinesin Light Chains Are Essential for Axonal Transport in Drosophila

Gindhart, Joseph G.; Desai, Chand J.; Beushausen, Sven; Zinn, Kai; Goldstein, Lawrence S.B.

doi:10.1083/jcb.141.2.443

Cited by 179Microtubule and mitosis dynamicsHereditary Neurological DisordersCellular transport and secretion

Kinesin Light Chains Are Essential for Axonal Transport in Drosophila

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Gindhart, Joseph G., Desai, Chand J., Beushausen, Sven, Zinn, Kai, Goldstein, Lawrence S.B.·1998·The Journal of Cell Biology

DOI 10.1083/jcb.141.2.443PMC PMC2148443

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Abstract

Kinesin is a heterotetramer composed of two 115-kD heavy chains and two 58-kD light chains. The microtubule motor activity of kinesin is performed by the heavy chains, but the functions of the light chains are poorly understood. Mutations were generated in the Drosophila gene Kinesin light chain (Klc), and the phenotypic consequences of loss of Klc function were analyzed at the behavioral and cellular levels. Loss of Klc function results in progressive lethargy, crawling defects, and paralysis followed by death at the end of the second larval instar. Klc mutant axons contain large aggregates of membranous organelles in segmental nerve axons. These aggregates, or organelle jams (Hurd, D.D., and W.M. Saxton. 1996. Genetics. 144: 1075-1085), contain synaptic vesicle precursors as well as organelles that may be transported by kinesin, kinesin-like protein 68D, and cytoplasmic dynein, thus providing evidence that the loss of Klc function blocks multiple pathways of axonal transport. The similarity of the Klc and Khc (. Cell 64:1093-1102; Hurd, D.D., and W.M. Saxton. 1996. Genetics 144: 1075-1085) mutant phenotypes indicates that KLC is essential for kinesin function, perhaps by tethering KHC to intracellular cargos or by activating the kinesin motor.

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Mutants lacking KLC in Drosophila melanogaster exhibit neuronal phenotypes similar to those seen when KHC is removed.
“Mutants lacking KLC in Drosophila melanogaster (Gindhart et al. 1998) exhibit neuronal phenotypes similar to that seen when KHC is removed.”
From Defective kinesin heavy chain behavior in mouse kinesin light chain mutants (1999) · cites this paper as Gindhart et al. 1998
Both KLC and KHC mutants in Drosophila exhibit membranous clogs in the segmental nerves.
“In fact, both KLC and KHC mutants in Drosophila exhibit membranous clogs in the segmental nerves (Hurd and Saxton 1996; Gindhart et al. 1998).”
From Defective kinesin heavy chain behavior in mouse kinesin light chain mutants (1999) · cites this paper as Gindhart et al. 1998
Results of disruption of KLC in Drosophila and mice suggest an essential role for KLC in kinesin function.
“However, the results of disruption of KLC in Drosophila and mice suggest an essential role for KLC in kinesin function (Gindhart et al. 1998).”
From Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules (2001) · cites this paper as Gindhart et al. 1998

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Dalby, B., Pereira, A., & Goldstein, L. S. B. (1995) · Genetics · doi:10.1093/genetics/139.2.757 · Cited by 48 · see citing works
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Molecular cloning and characterization of human kinectin.
Fütterer, A., Kruppa, G., Krämer, B., Lemke, H., & Krönke, M. (1995) · Molecular Biology of the Cell · doi:10.1091/mbc.6.2.161 · Cited by 48 · see citing works
Sequences of Sea Urchin Kinesin Light Chain Isoforms
Wedaman, K. P., Knight, A. E., Kendrick‐Jones, J., & Scholey, J. M. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1267 · Cited by 47 · see citing works
Motor activity and mitotic spindle localization of the Drosophila kinesin-like protein KLP61F.
Barton, N. R., Pereira, A., & Goldstein, L. S. B. (1995) · Molecular Biology of the Cell · doi:10.1091/mbc.6.11.1563 · Cited by 45 · see citing works
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AVEC-DIC and electron microscopic analyses of axonally transported particles in cold-blocked squid giant axons
Fahim, M. A., Lasek, R. J., Brady, S. T., & Hodge, A. J. (1985) · Journal of Neurocytology · doi:10.1007/bf01170822 · Cited by 45 · see citing works
Phosphotransferases Associated with the Regulation of Kinesin Motor Activity
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Light chains of sea urchin kinesin identified by immunoadsorption
Johnson, C. S., Buster, D., & Scholey, J. M. (1990) · Cell Motility · doi:10.1002/cm.970160307 · Cited by 37 · see citing works
Kinesin Light Chains: Identification and Characterization of a Family of Proteins from the Optic Lobe of the Squid Loligo pealii
Beushausen, S. A., Kladakis, A., & Jaffe, H. (1993) · DNA and Cell Biology · doi:10.1089/dna.1993.12.901 · Cited by 36 · see citing works
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The axonal transport motor ‘kinesin’ is bound to anterogradely transported organelles: quantitative cytofluorimetric studies of fast axonal transport in the rat
Dahlström, A. B., Pfister, K. K., & Brady, S. T. (1991) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1991.tb09107.x · Cited by 35 · see citing works
A kinesin-like mechanoenzyme from the zygomycete Syncephalastrum racemosum shares biochemical similarities with conventional kinesin from Neurospora crassa.
Steinberg, G. (1997) · PubMed · Cited by 33 · see citing works
Evidence that the 116 kDa component of kinesin binds and hydrolyses ATP
Penningroth, S. M., Rose, P. M., & Peterson, D. D. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80220-x · Cited by 31 · see citing works
Kinesin Light Chain Isoforms in Caenorhabditis elegans
Fan, J., & Amos, L. (1994) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.1465 · Cited by 26 · see citing works
Cargo-activated ATPase activity of kinesin.
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Cloning and Genetic Characterization of the Human Kinesin Light-Chain (KLC) Gene
Cabeza-Arvelaiz, Y., SHIH, L.-C. N., Hardman, N., ASSELBERGS, F., Bilbe, G., Schmitz, A., WHITE, B., Siciliano, M. J., & Lachman, L. B. (1993) · DNA and Cell Biology · doi:10.1089/dna.1993.12.881 · Cited by 23 · see citing works
Drosophila Genetics and the Functions of Synaptic ProteinsPreprint
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Human Kinesin Light (β) Chain Gene: DNA Sequence and Functional Characterization of Its Promoter and First Exon
Chernajovsky, Y., BROWN, A., & CLARK, J. (1996) · DNA and Cell Biology · doi:10.1089/dna.1996.15.965 · Cited by 5 · see citing works
Kinesin Light Chain in a Eubacterium
Celerin, M., Gilpin, A., dosSantos, G., Laudenbach, D. E., CLARKE, M. W., & Beushausen, S. A. (1997) · DNA and Cell Biology · doi:10.1089/dna.1997.16.787 · Cited by 5 · see citing works
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Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia
Hakak, Y., Walker, J. R., Li, C., Wong, W. H., Davis, K. L., Buxbaum, J. D., Haroutunian, V., & Fienberg, A. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081071198 · Cited by 1,192 · see citing works
The axonal transport of mitochondria
Saxton, W. M., & Hollenbeck, P. J. (2012) · Journal of Cell Science · doi:10.1242/jcs.053850 · Cited by 1,198 · see citing works
Molecular motors and mechanisms of directional transport in neurons
Hirokawa, N., & Takemura, R. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1624 · Cited by 830 · see citing works
The axonal transport of mitochondria
Hollenbeck, P. J., & Saxton, W. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02745 · Cited by 771 · see citing works
Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent
Glater, E. E., Megeath, L. J., Stowers, R. S., & Schwarz, T. L. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200601067 · Cited by 667 · see citing works
Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules
Verhey, K. J., Meyer, D., Deehan, R., Blenis, J., Schnapp, B. J., Rapoport, T. A., & Margolis, B. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.5.959 · Cited by 609 · see citing works
Microtubule-Based Transport Systems in Neurons: The Roles of Kinesins and Dyneins
Goldstein, L. S. B., & Yang, Z. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.39 · Cited by 552 · see citing works
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Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I
Kamal, A., Stokin, G. B., Yang, Z., Xia, C.-H., & Goldstein, L. S. B. (2000) · Neuron · doi:10.1016/s0896-6273(00)00124-0 · Cited by 544 · see citing works
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Intracellular Transport and Kinesin Superfamily Proteins, KIFs: Structure, Function, and Dynamics
Hirokawa, N., & Noda, Y. (2008) · Physiological Reviews · doi:10.1152/physrev.00023.2007 · Cited by 510 · see citing works
Drosophila Futsch/22C10 Is a MAP1B-like Protein Required for Dendritic and Axonal Development
Hummel, T., Krukkert, K., Roos, J., Davis, G. W., & Klämbt, C. (2000) · Neuron · doi:10.1016/s0896-6273(00)81169-1 · Cited by 464 · see citing works
Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila
Gunawardena, S., & Goldstein, L. S. B. (2001) · Neuron · doi:10.1016/s0896-6273(01)00496-2 · Cited by 428 · see citing works
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Consequences of Motor Copy Number on the Intracellular Transport of Kinesin-1-Driven Lipid Droplets
Shubeita, G. T., Tran, S. L., Xu, J., Vershinin, M. D., Cermelli, S., Cotton, S. L., Welte, M. A., & Gross, S. P. (2008) · Cell · doi:10.1016/j.cell.2008.10.021 · Cited by 368 · see citing works
Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport
Martin, M., Iyadurai, S. J., Gassman, A., Gindhart, J. G., Hays, T. S., & Saxton, W. M. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.11.3717 · Cited by 365 · see citing works
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KIF5C, a Novel Neuronal Kinesin Enriched in Motor Neurons
Kanai, Y., Okada, Y., Tanaka, Y., Harada, A., Terada, S., & Hirokawa, N. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06374.2000 · Cited by 334 · see citing works
Kinesin-Dependent Axonal Transport Is Mediated by the Sunday Driver (SYD) Protein
Bowman, A. B., Kamal, A., Ritchings, B. W., Philp, A. V., McGrail, M. A., Gindhart, J. G., & Goldstein, L. S. B. (2000) · Cell · doi:10.1016/s0092-8674(00)00162-8 · Cited by 331 · see citing works
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Axonal Transport and Alzheimer's Disease
Stokin, G. B., & Goldstein, L. S. B. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142637 · Cited by 292 · see citing works
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MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function
Metzger, T. E., Gache, V., Xu, M., Cadot, B., Folker, E. S., Richardson, B. E., Gomes, E. R., & Baylies, M. K. (2012) · Nature · doi:10.1038/nature10914 · Cited by 280 · see citing works
The Road Less Traveled: Emerging Principles of Kinesin Motor Utilization
Goldstein, L. S. B., & Philp, A. V. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.141 · Cited by 269 · see citing works
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GSK-3β inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila
Mudher, A., Shepherd, D., Newman, T. A., Mildren, P., Jukes, J. P., Squire, A., Mears, A., Berg, S., MacKay, D., Asuni, A. A., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001483 · Cited by 265 · see citing works
Drosophila VAP-33A Directs Bouton Formation at Neuromuscular Junctions in a Dosage-Dependent Manner
Pennetta, G., Hiesinger, P. R., Fabian‐Fine, R., Meinertzhagen, I. A., & Bellen, H. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00769-9 · Cited by 215 · see citing works
Drosophila Lis1 is required for neuroblast proliferation, dendritic elaboration and axonal transport
Liu, Z., Steward, R., & Luo, L. (2000) · Nature Cell Biology · doi:10.1038/35041011 · Cited by 203 · see citing works
Membrane trafficking, organelle transport, and the cytoskeleton
Rogers, S. L., & Gelfand, V. I. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00057-5 · Cited by 194 · see citing works
Kinesin light chain -independent function of the Kinesin heavy chain in cytoplasmic streaming and posterior localisation in the Drosophila oocyte
Palacios, I. M., & Johnston, D. S. (2002) · Development · doi:10.1242/dev.00119 · Cited by 184 · see citing works
Identification of an Axonal Kinesin-3 Motor for Fast Anterograde Vesicle Transport that Facilitates Retrograde Transport of Neuropeptides
Barkus, R. V., Klyachko, O., Horiuchi, D., Dickson, B. J., & Saxton, W. M. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-03-0261 · Cited by 185 · see citing works
Transport of Drosophila fragile X mental retardation protein-containing ribonucleoprotein granules by kinesin-1 and cytoplasmic dynein
Ling, S., Fahrner, P. S., Greenough, W. T., & Gelfand, V. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408114101 · Cited by 169 · see citing works
Kinesin-1 structural organization and conformational changes revealed by FRET stoichiometry in live cells
Cai, D., Hoppe, A. D., Swanson, J. A., & Verhey, K. J. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200605097 · Cited by 164 · see citing works
A Direct Interaction between Cytoplasmic Dynein and Kinesin I May Coordinate Motor Activity
Ligon, L. A., Tokito, M. K., Finklestein, J. M., Grossman, F. E., & Holzbaur, E. L. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313472200 · Cited by 164 · see citing works
Involvement of conventional kinesin in glucose-stimulated secretory granule movements and exocytosis in clonal pancreatic β-cells
Varadi, A., Ainscow, E. K., Allan, V. J., & Rutter, G. A. (2002) · Journal of Cell Science · doi:10.1242/jcs.00083 · Cited by 156 · see citing works
The Cytoplasmic Dynein and Kinesin Motors Have Interdependent Roles in Patterning the Drosophila Oocyte
Duncan, J. E., & Warrior, R. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01303-9 · Cited by 155 · see citing works
Control of a Kinesin-Cargo Linkage Mechanism by JNK Pathway Kinases
Horiuchi, D., Collins, C. A., Bhat, P., Barkus, R. V., DiAntonio, A., & Saxton, W. M. (2007) · Current Biology · doi:10.1016/j.cub.2007.06.062 · Cited by 154 · see citing works
Drosophila roadblock and Chlamydomonas Lc7
Bowman, A. B., Patel, R., Benashski, S. E., McCaffery, J. M., Goldstein, L. S. B., & King, S. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.1.165 · Cited by 153 · see citing works
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The Genetics of Axonal Transport and Axonal Transport Disorders
Duncan, J. E., & Goldstein, L. S. B. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020124 · Cited by 150 · see citing works
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Cargo binding and regulatory sites in the tail of fungal conventional kinesin
Seiler, S., Kirchner, J., Horn, C., Kallipolitou, A., Woehlke, G., & Schliwa, M. (2000) · Nature Cell Biology · doi:10.1038/35014022 · Cited by 147 · see citing works
Cargo‐carrying motor vehicles on the neuronal highway: Transport pathways and neurodegenerative disease
Gunawardena, S., & Goldstein, L. S. B. (2003) · Journal of Neurobiology · doi:10.1002/neu.10319 · Cited by 147 · see citing works
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APLIP1, a Kinesin Binding JIP-1/JNK Scaffold Protein, Influences the Axonal Transport of Both Vesicles and Mitochondria in Drosophila
Horiuchi, D., Barkus, R. V., Pilling, A. D., Gassman, A., & Saxton, W. M. (2005) · Current Biology · doi:10.1016/j.cub.2005.10.047 · Cited by 141 · see citing works
UNC-51/ATG1 kinase regulates axonal transport by mediating motor–cargo assemblyPreprint
Toda, H., Mochizuki, H., Flores, R., Josowitz, R., Krasieva, T. B., LaMorte, V. J., Suzuki, E., Gindhart, J. G., Furukubo-Tokunaga, K., & Tomoda, T. (2008) · Genes & Development · doi:10.1101/gad.1734608 · Cited by 141 · see citing works
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Walking on two heads: the many talents of kinesin
Woehlke, G., & Schliwa, M. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036069 · Cited by 138 · see citing works
AMP-Activated Protein Kinase Regulates Neuronal Polarization by Interfering with PI 3-Kinase Localization
Amato, S., Liu, X., Zheng, B., Cantley, L. C., RAKIC, P. T., & Man, H. (2011) · Science · doi:10.1126/science.1201678 · Cited by 129 · see citing works
Dynactin Is Required for Coordinated Bidirectional Motility, but Not for Dynein Membrane Attachment
Haghnia, M., Cavalli, V., Shah, S. B., Schimmelpfeng, K., Brusch, R., Yang, G., Herrera, C. M., Pilling, A. D., & Goldstein, L. S. B. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-08-0695 · Cited by 128 · see citing works
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Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?
Götz, J., Ittner, L. M., & Kins, S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03955.x · Cited by 114 · see citing works
Kinesin-II Is Required for Axonal Transport of Choline Acetyltransferase in Drosophila
Ray, K., Perez, S. E., Yang, Z., Xu, J., Ritchings, B. W., Steller, H., & Goldstein, L. S. B. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.3.507 · Cited by 113 · see citing works
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Dynein light chain regulates axonal trafficking and synaptic levels of Bassoon
Fejtová, A., Davydova, D., Bischof, F., Lazarevic, V., Altrock, W. D., Romorini, S., Schöne, C., Zuschratter, W., Kreutz, M. R., Garner, C. C., et al. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200807155 · Cited by 113 · see citing works
Fast transport of neurofilament protein along microtubules in squid axoplasm
Prahlad, V., Helfand, B. T., Langford, G. M., Vale, R. D., & Goldman, R. D. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.22.3939 · Cited by 111 · see citing works
Sunday Driver/JIP3 binds kinesin heavy chain directly and enhances its motility
Sun, F., Zhu, C., Dixit, R., & Cavalli, V. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.229 · Cited by 107 · see citing works
Targeted Expression of TruncatedGluedDisrupts Giant Fiber Synapse Formation inDrosophila
Allen, M. J., Shan, X., Caruccio, P., Froggett, S. J., Moffat, K. G., & Murphey, R. K. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09374.1999 · Cited by 103 · see citing works
Mutations in Caenorhabditis elegans Cytoplasmic Dynein Components Reveal Specificity of Neuronal Retrograde Cargo
Koushika, S. P., Schaefer, A. M., Vincent, R., Willis, J. H., Bowerman, B. A., & Nonet, M. L. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5039-03.2004 · Cited by 103 · see citing works
Defective kinesin heavy chain behavior in mouse kinesin light chain mutants
Rahman, A., Kamal, A., Roberts, E. A., & Goldstein, L. S. B. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.6.1277 · Cited by 102 · see citing works
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High‐resolution imaging demonstrates dynein‐based vesicular transport of activated trk receptors
Bhattacharyya, A., Watson, F. L., Pomeroy, S. L., Zhang, Y. Z., Stiles, C. D., & Segal, R. A. (2002) · Journal of Neurobiology · doi:10.1002/neu.10062 · Cited by 100 · see citing works
Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington’s disease model
Zhang, S., Feany, M. Β., Saraswati, S., Littleton, J. T., & Perrimon, N. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.000653 · Cited by 94 · see citing works
Cargo selection by specific kinesin light chain 1 isoforms
Wozniak, M. J., & Allan, V. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601427 · Cited by 96 · see citing works
TheCaenorhabditis elegansJIP3 Protein UNC-16 Functions As an Adaptor to Link Kinesin-1 with Cytoplasmic Dynein
Arimoto, M., Koushika, S. P., Choudhary, B. C., Li, C., Matsumoto, K., & Hisamoto, N. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2653-10.2011 · Cited by 95 · see citing works
Biophysical Challenges to Axonal Transport: Motor-Cargo Deficiencies and Neurodegeneration
Encalada, S. E., & Goldstein, L. S. B. (2014) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-051013-022746 · Cited by 93 · see citing works
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Release of Kinesin from Vesicles by hsc70 and Regulation of Fast Axonal Transport
Tsai, M.-Y., Morfini, G. A., Szebenyi, G., & Brady, S. T. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.6.2161 · Cited by 94 · see citing works
Motor and cargo interactions
Sheetz, M. P. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00340.x · Cited by 91 · see citing works
The Kinesin-associated Protein UNC-76 Is Required for Axonal Transport in theDrosophilaNervous System
Gindhart, J. G., Chen, J., Faulkner, M., Gandhi, R., Doerner, K., Wisniewski, T., & Nandlestadt, A. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-12-0800 · Cited by 90 · see citing works
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A New Component in Synaptic Plasticity: Upregulation of Kinesin in the Neurons of the Gill-Withdrawal Reflex
Puthanveettil, S. V., Monje, F. J., Miniaci, M. C., Choi, Y., Karl, K. A., Khandros, E., Gawinowicz, M. A., Sheetz, M. P., & Kandel, E. R. (2008) · Cell · doi:10.1016/j.cell.2008.11.003 · Cited by 88 · see citing works
Defects in Mitochondrial Axonal Transport and Membrane Potential without Increased Reactive Oxygen Species Production in aDrosophilaModel of Friedreich Ataxia
Shidara, Y., & Hollenbeck, P. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0529-10.2010 · Cited by 86 · see citing works
Role of kinesin-1–based microtubule sliding in Drosophila nervous system development
Winding, M., Kelliher, M. T., Lü, W., Wildonger, J., & Gelfand, V. I. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522416113 · Cited by 85 · see citing works
Conventional Kinesin Mediates Microtubule-Microtubule Interactions In Vivo
Straube, A., Hause, G., Fink, G., & Steinberg, G. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-06-0542 · Cited by 81 · see citing works
Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in<i>Drosophila</i>
Reis, G. F., Yang, G., Szpankowski, L., Weaver, C., Shah, S. B., Robinson, J. T., Hays, T. S., Danuser, G., & Goldstein, L. S. B. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-11-0938 · Cited by 80 · see citing works
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The machinery of mitochondrial fusion, division, and distribution, and emerging connections to apoptosis
Hales, K. G. (2004) · Mitochondrion · doi:10.1016/j.mito.2004.05.007 · Cited by 70 · see citing works
Increasing Tip60 HAT Levels Rescues Axonal Transport Defects and Associated Behavioral Phenotypes in aDrosophilaAlzheimer's Disease Model
Johnson, A. A., Sarthi, J. B., Pirooznia, S. K., Reube, W., & Elefant, F. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3739-12.2013 · Cited by 69 · see citing works
An Organelle Gatekeeper Function for Caenorhabditis elegans UNC-16 (JIP3) at the Axon Initial Segment
Edwards, S. L., Yu, S.-C., Hoover, C., Phillips, B. C., Richmond, J. E., & Miller, K. G. (2013) · Genetics · doi:10.1534/genetics.112.147348 · Cited by 68 · see citing works
Presynaptic LRP4 promotes synapse number and function of excitatory CNS neurons
Mosca, T. J., Luginbuhl, D. J., Wang, I. E., & Luo, L. (2017) · eLife · doi:10.7554/elife.27347 · Cited by 65 · see citing works
Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies
Falzone, T. L., Gunawardena, S., McCleary, D. F., Reis, G. F., & Goldstein, L. S. B. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq363 · Cited by 65 · see citing works
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Translocating myonuclei have distinct leading and lagging edges that require Kinesin and Dynein
Folker, E. S., Schulman, V. K., & Baylies, M. K. (2013) · Development · doi:10.1242/dev.095612 · Cited by 62 · see citing works
Insights into Kinesin-1 Activation from the Crystal Structure of KLC2 Bound to JIP3
Cockburn, J. J. B., Hesketh, S. J., Mulhair, P. O., Thomsen, M., O’Connell, M. J., & Way, M. (2018) · Structure · doi:10.1016/j.str.2018.07.011 · Cited by 57 · see citing works
Drosophila Models of Tauopathies: What Have We Learned?
Gistelinck, M., Lambert, J., Callaerts, P., Dermaut, B., & Dourlen, P. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/970980 · Cited by 58 · see citing works
Crystal Structures of the Tetratricopeptide Repeat Domains of Kinesin Light Chains: Insight into Cargo Recognition Mechanisms
Zhu, H., Lee, H. Y., Tong, Y., Hong, B., Kim, K.-P., Shen, Y., Lim, K. J., MacKenzie, F., Tempel, W., & Park, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033943 · Cited by 58 · see citing works
mNUDC is required for plus‐end‐directed transport of cytoplasmic dynein and dynactins by kinesin‐1
Yamada, M., Toba, S., Takitoh, T., Yoshida, Y., Mori, D., Nakamura, T., Iwane, A. H., Yanagida, T., Imai, H., Yu-Lee, L.-Y., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.378 · Cited by 58 · see citing works
Bruchpilot in Ribbon-Like Axonal Agglomerates, Behavioral Defects, and Early Death in SRPK79D Kinase Mutants of Drosophila
Nieratschker, V., Schubert, A., Jauch, M., Bock, N., Bucher, D. B., Dippacher, S., Krohne, G., Asan, E., Buchner, S., & Buchner, E. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000700 · Cited by 56 · see citing works
Enhanced -secretase processing alters APP axonal transport and leads to axonal defects
Rodrigues, E. M., Weissmiller, A. M., & Goldstein, L. S. B. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds297 · Cited by 55 · see citing works
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Building Blocks of Functioning Brain: Cytoskeletal Dynamics in Neuronal Development
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Self-citation

Authors: Gindhart, J. G., Desai, C. J., Beushausen, S., Zinn, K., & Goldstein, L. S. B.
Affiliations: California Institute of Technology (US)
ORCID: Zinn, Kai
Goldstein, Lawrence S.B.
Venue: The Journal of Cell Biology
Publisher: Rockefeller University Press
Published: 1998-04-20
Volume: 141
Issue: 2
Pages: 443-454
ISSN: 0021-9525 (ISSN-L)
1540-8140
DOI: 10.1083/jcb.141.2.443
PMC: PMC2148443
OpenAlex: W2099198611
Cited by: 179
References: 105
Citations by year: 2026: 4 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 6 · 2017: 9 · 2016: 3 · 2015: 5 · 2014: 8 · 2013: 7 · 2012: 10
FWCI: 4.32
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: The Journal of Cell Biology (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion, cc-by-nc-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: kinesin light chain, axonal transport, kinesin heavy chain, Drosophila, cytoplasmic dynein, cargo binding, paralysis, larval mortality
MeSH terms: Animals, Axonal Transport, Drosophila, Larva, Microtubule-Associated Proteins, Movement, Mutation, Nerve Tissue Proteins, Neurons, Paralysis, Phenotype, Kinesins, Genes, Insect, Animals, Genetically Modified

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Kinesin Light Chains Are Essential for Axonal Transport in Drosophila

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