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The Mammalian Calcium-binding Protein, Nucleobindin (CALNUC), Is a Golgi Resident Protein
Open accessAbstract
We have identified CALNUC, an EF-hand, Ca2+-binding protein, as a Golgi resident protein. CALNUC corresponds to a previously identified EF-hand/calcium-binding protein known as nucleobindin. CALNUC interacts with Gαi3 subunits in the yeast two-hybrid system and in GST-CALNUC pull-down assays. Analysis of deletion mutants demonstrated that the EF-hand and intervening acidic regions are the site of CALNUC's interaction with Gαi3. CALNUC is found in both cytosolic and membrane fractions. The membrane pool is tightly associated with the luminal surface of Golgi membranes. CALNUC is widely expressed, as it is detected by immunofluorescence in the Golgi region of all tissues and cell lines examined. By immunoelectron microscopy, CALNUC is localized to cis-Golgi cisternae and the cis-Golgi network (CGN). CALNUC is the major Ca2+-binding protein detected by 45Ca2+-binding assay on Golgi fractions. The properties of CALNUC and its high homology to calreticulin suggest that it may play a key role in calcium homeostasis in the CGN and cis-Golgi cisternae.
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Cited by
Calreticulin: one protein, one gene, many functions
Michalak, M., Corbett, E. F., Mesaeli, N., Nakamura, K., & Opas, M. (1999) · Biochemical Journal · doi:10.1042/0264-6021:3440281 · Cited by 830
Calcium Pumps in Health and Disease
Brini, M., & Carafoli, E. (2009) · Physiological Reviews · doi:10.1152/physrev.00032.2008 · Cited by 676
Generation, Control, and Processing of Cellular Calcium Signals
Carafoli, E., Santella, L., Branca, D., & Brini, M. (2001) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/20014091074183 · Cited by 531
Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer’s Disease
Song, W.-J., Son, M.-Y., Lee, H.-W., Seo, H., Kim, J. H., & Chung, S.-H. (2015) · PLOS ONE · doi:10.1371/journal.pone.0136950 · Cited by 50
Calnuc Binds to LRP9 and Affects its Endosomal Sorting
Brodeur, J., Larkin, H., Boucher, R., Thériault, C., St‐Louis, S. C., Gagnon, H., & Lavoie, C. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00933.x · Cited by 44
Metadata
- Authors
- Lin, P., Le-Niculescu, H., Hofmeister, R., Michael McCaffery, J., Jin, M., Hennemann, H., McQuistan, T., De Vries, L., & Farquhar, M. G.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1998-06-29
- Volume
- 141
- Issue
- 7
- Pages
- 1515-1527
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2018833058
- Cited by
- 163
- References
- 0
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The Mammalian Calcium-binding Protein, Nucleobindin (CALNUC), Is a Golgi Resident Protein. https://app.cochat.ai/papers/10.1083/jcb.141.7.1515
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- Lin, P., Le-Niculescu, H., Hofmeister, R., Michael McCaffery, J., Jin, M., Hennemann, H., McQuistan, T., De Vries, L., & Farquhar, M. G. (1998). The Mammalian Calcium-binding Protein, Nucleobindin (CALNUC), Is a Golgi Resident Protein. The Journal of Cell Biology. https://doi.org/10.1083/jcb.141.7.1515
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