The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer’s Disease
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
BACE1 is phosphorylated, with phosphorylation at threonine 252 via p25/Cdk5 pathways found to stimulate protease activity.
“BACE1 is also phosphorylated, with phosphorylation at threonine 252 via p25/Cdk5 pathways found to stimulate protease activity.”
From BACE1: More than just a β‐secretase (2022) · cites this paper as [78]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kawarabayashi, T., Younkin, L. H., Saido, T. C., Shoji, M., Ashe, K. H., & Younkin, S. G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00372.2001 · Cited by 1,053
β-Secretase Activity Increases with Aging in Human, Monkey, and Mouse Brain
Fukumoto, H., Rosene, D. L., Moss, M. B., Raju, S., Hyman, B. T., & Irizarry, M. C. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63159-8 · Cited by 294
Yu, W. H., Kumar, A., Peterhoff, C., Shapiro Kulnane, L., Uchiyama, Y., Lamb, B. T., Cuervo, A. M., & Nixon, R. A. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.05.010 · Cited by 279
Fischer, A., Sananbenesi, F., Pang, P. T., Lu, B., & Tsai, L.-H. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.033 · Cited by 277
A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains
Tseng, H.-C., Zhou, Y., Shen, Y., & Tsai, L.-H. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02934-4 · Cited by 198
Flagged first, then by citations
Research works printed but not linked: 55
- R Vassar, 1999, Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE, Science, 286, 735, 10.1126/science.286.5440.735 · DOI · Paper page
- J Apelt, 2004, Aging-related increase in oxidative stress correlates with developmental pattern of beta-secretase activity and beta-amyloid plaque formation in transgenic Tg2576 mice with Alzheimer-like pathology, Int J Dev Neurosci, 22, 475, 10.1016/j.ijdevneu.2004.07.006 · DOI
- H Fukumoto, 2002, Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease, Arch Neurol, 59, 1381, 10.1001/archneur.59.9.1381 · DOI · Paper page
- RM Holsinger, 2002, Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease, Ann Neurol, 51, 783, 10.1002/ana.10208 · DOI · Paper page
- KR Sadleir, 2012, Cdk5 protein inhibition and Abeta42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer disease, J Biol Chem, 287, 7224, 10.1074/jbc.M111.333914 · DOI
- LB Yang, 2003, Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease, Nat Med, 9, 3, 10.1038/nm0103-3 · DOI · Paper page
- H Harada, 2006, Beta-site APP cleaving enzyme 1 (BACE1) is increased in remaining neurons in Alzheimer's disease brains, Neurosci Res, 54, 24, 10.1016/j.neures.2005.10.001 · DOI
- JH Stockley, 2006, Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain, FEBS Lett, 580, 6550, 10.1016/j.febslet.2006.10.076 · DOI
- G Leuba, 2005, Neuronal and nonneuronal quantitative BACE immunocytochemical expression in the entorhinohippocampal and frontal regions in Alzheimer's disease, Dement Geriatr Cogn Disord, 19, 171, 10.1159/000083496 · DOI
- SS Hebert, 2008, Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression, Proc Natl Acad Sci U S A, 105, 6415, 10.1073/pnas.0710263105 · DOI · Paper page
- K Yasojima, 2001, Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain, Brain Res, 919, 115, 10.1016/S0006-8993(01)03008-6 · DOI
- P Preece, 2003, Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease, Brain Res Mol Brain Res, 116, 155, 10.1016/S0169-328X(03)00233-X · DOI
- JH Stockley, 2008, Understanding BACE1: essential protease for amyloid-beta production in Alzheimer's disease, Cell Mol Life Sci, 65, 3265, 10.1007/s00018-008-8271-3 · DOI
- R Dhavan, 2001, A decade of CDK5, Nat Rev Mol Cell Biol, 2, 749, 10.1038/35096019 · DOI
- GN Patrick, 1999, Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration, Nature, 402, 615, 10.1038/45159 · DOI
- JE Swatton, 2004, Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain, Eur J Neurosci, 19, 2711, 10.1111/j.0953-816X.2004.03365.x · DOI
- A Tandon, 2003, Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles, J Neurochem, 86, 572, 10.1046/j.1471-4159.2003.01865.x · DOI
- Y Wen, 2008, Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing, Neuron, 57, 680, 10.1016/j.neuron.2008.02.024 · DOI
- MY Son, 2010, Expression of p25, an aberrant cyclin-dependent kinase 5 activator, stimulates basal secretion in PC12 cells, Mol Cells, 29, 51, 10.1007/s10059-010-0016-0 · DOI
- SH Chung, 1995, Evidence that the Rab3a-binding protein, rabphilin3a, enhances regulated secretion. Studies in adrenal chromaffin cells, J Biol Chem, 270, 16714, 10.1074/jbc.270.28.16714 · DOI
- MK Ahlijanian, 2000, Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5, Proc Natl Acad Sci U S A, 97, 2910, 10.1073/pnas.040577797 · DOI
- H Seo, 2004, Generalized brain and skin proteasome inhibition in Huntington's disease, Ann Neurol, 56, 319, 10.1002/ana.20207 · DOI · Paper page
- JH Park, 2012, Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11alpha, J Neurochem, 122, 1081, 10.1111/j.1471-4159.2012.07861.x · DOI
- SR Ryoo, 2007, DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease, J Biol Chem, 282, 34850, 10.1074/jbc.M707358200 · DOI
- MS Lee, 2003, APP processing is regulated by cytoplasmic phosphorylation, J Cell Biol, 163, 83, 10.1083/jcb.200301115 · DOI
- P Lin, 1998, The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident protein, J Cell Biol, 141, 1515, 10.1083/jcb.141.7.1515 · DOI
- SY Lee, 2004, Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses, Proc Natl Acad Sci U S A, 101, 546, 10.1073/pnas.0307813100 · DOI
- A Schmechel, 2004, Human BACE forms dimers and colocalizes with APP, J Biol Chem, 279, 39710, 10.1074/jbc.M402785200 · DOI
- C Sidera, 2002, Pro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pH, BMC Biochem, 3, 25, 10.1186/1471-2091-3-25 · DOI
- L Marlow, 2003, Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP), J Mol Neurosci, 20, 233, 10.1385/JMN:20:3:233 · DOI
- K Iijima, 2000, Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5, J Neurochem, 75, 1085, 10.1046/j.1471-4159.2000.0751085.x · DOI
- GG Westmeyer, 2004, Dimerization of BACE, J Biol Chem, 279, 53205
- L Hong, 2000, Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor, Science, 290, 150, 10.1126/science.290.5489.150 · DOI
- HW Lee, 2007, Overexpression of BACE1 stimulates spontaneous basal secretion in PC12 cells, Neurosci Lett, 421, 178, 10.1016/j.neulet.2007.01.082 · DOI
- JT Huse, 2000, Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase, J Biol Chem, 275, 33729, 10.1074/jbc.M004175200 · DOI · Paper page
- X Sun, 2012, Regulation of beta-site APP-cleaving enzyme 1 gene expression and its role in Alzheimer's disease, J Neurochem, 120, 62, 10.1111/j.1471-4159.2011.07515.x · DOI
- R Sultana, 2007, Regional expression of key cell cycle proteins in brain from subjects with amnestic mild cognitive impairment, Neurochem Res, 32, 655, 10.1007/s11064-006-9123-x · DOI
- P Giusti-Rodriguez, 2011, Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of beta-secretase (BACE1), J Neurosci, 31, 15751, 10.1523/JNEUROSCI.3588-11.2011 · DOI
- AD Snow, 1990, Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein-containing lesions of Alzheimer's disease and Down's syndrome, Am J Pathol, 137, 1253
- G Perry, 1991, Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease, J Neurosci, 11, 3679, 10.1523/JNEUROSCI.11-11-03679.1991 · DOI
- AM Cataldo, 2000, Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations, Am J Pathol, 157, 277, 10.1016/S0002-9440(10)64538-5 · DOI · Paper page
- AM Cataldo, 2004, Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome, Neurobiol Aging, 25, 1263, 10.1016/j.neurobiolaging.2004.02.027 · DOI · Paper page
- CM Fader, 2009, Autophagy and multivesicular bodies: two closely related partners, Cell Death Differ, 16, 70, 10.1038/cdd.2008.168 · DOI
- WH Yu, 2005, Macroautophagy—a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease, J Cell Biol, 171, 87, 10.1083/jcb.200505082 · DOI · Paper page
- RA Nixon, 2005, Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study, J Neuropathol Exp Neurol, 64, 113, 10.1093/jnen/64.2.113 · DOI · Paper page
- RA Nixon, 2011, Autophagy failure in Alzheimer's disease—locating the primary defect, Neurobiol Dis, 43, 38, 10.1016/j.nbd.2011.01.021 · DOI · Paper page
- K Ditaranto, 2001, Lysosomal membrane damage in soluble Abeta-mediated cell death in Alzheimer's disease, Neurobiol Dis, 8, 19, 10.1006/nbdi.2000.0364 · DOI
- AJ Yang, 1998, Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis, J Neurosci Res, 52, 691, 10.1002/(SICI)1097-4547(19980615)52:6<691::AID-JNR8>3.0.CO;2-3 · DOI
- VF Taelman, 2010, Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes, Cell, 143, 1136, 10.1016/j.cell.2010.11.034 · DOI · Paper page
- RH Takahashi, 2002, Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology, Am J Pathol, 161, 1869, 10.1016/S0002-9440(10)64463-X · DOI · Paper page
- PA Lochhead, 2005, Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs, Cell, 121, 925, 10.1016/j.cell.2005.03.034 · DOI
- L Liu, 2013, Palmitate-activated astrocytes via serine palmitoyltransferase increase BACE1 in primary neurons by sphingomyelinases, Neurobiol Aging, 34, 540, 10.1016/j.neurobiolaging.2012.05.017 · DOI
- W Noble, 2003, Cdk5 is a key factor in tau aggregation and tangle formation in vivo, Neuron, 38, 555, 10.1016/S0896-6273(03)00259-9 · DOI
- JC Cruz, 2003, Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles, Neuron, 40, 471, 10.1016/S0896-6273(03)00627-5 · DOI · Paper page
- JC Cruz, 2006, p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo, J Neurosci, 26, 10536, 10.1523/JNEUROSCI.3133-06.2006 · DOI
Cited by
Sorted by citations
The β-Secretase BACE1 in Alzheimer’s Disease
Hampel, H., Vassar, R., De Strooper, B., Hardy, J., Willem, M., Singh, N., Zhou, J., Yan, R., Vanmechelen, E., De Vos, A., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.02.001 · Cited by 694
Nixon, R. A. (2017) · The FASEB Journal · doi:10.1096/fj.201700359 · Cited by 400
BACE1: More than just a β‐secretase
Taylor, H. A., Przemylska, L., Clavane, E. M., & Meakin, P. J. (2022) · Obesity Reviews · doi:10.1111/obr.13430 · Cited by 107
Li, Z., Yin, B., Zhang, S., Lan, Z., & Zhang, L. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115817 · Cited by 54
Vergallo, A., Houot, M., Cavedo, E., Lemercier, P., Vanmechelen, E., De Vos, A., Habert, M., Potier, M., Dubois, B., Lista, S., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.07.001 · Cited by 32
Metadata
- Authors
- Song, W.-J., Son, M.-Y., Lee, H.-W., Seo, H., Kim, J. H., & Chung, S.-H.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-08-28
- Volume
- 10
- Issue
- 8
- Pages
- e0136950
- ISSN
- 1932-6203
- PMC
- PMC4552876
- Cited by
- 50
- References
- 5
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review