The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Septins Are Required for the Mitosis-specific Activation of the Gin4 Kinase
Open accessAbstract
In budding yeast, a protein kinase called Gin4 is specifically activated during mitosis and functions in a pathway initiated by the Clb2 cyclin to control bud growth. We have used genetics and biochemistry to identify additional proteins that function with Gin4 in this pathway, and both of these approaches have identified members of the septin family. Loss of septin function produces a phenotype that is very similar to the phenotype caused by loss of Gin4 function, and the septins are required early in mitosis to activate Gin4 kinase activity. Furthermore, septin mutants display a prolonged mitotic delay at the short spindle stage, consistent with a role for the septins in the control of mitotic events. Members of the septin family bind directly to Gin4, demonstrating that the functions of Gin4 and the septins must be closely linked within the cell. These results demonstrate that the septins in budding yeast play an integral role in the mitosis-specific regulation of the Gin4 kinase and that they carry out functions early in mitosis.
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Cites
The GTPase superfamily: conserved structure and molecular mechanism
Bourne, H. R., Sanders, D. A., & McCormick, F. (1991) · Nature · doi:10.1038/349117a0 · Cited by 3,392
Cited by
The pathobiology of the septin gene family
Hall, P. A., & Russell, S. H. (2004) · The Journal of Pathology · doi:10.1002/path.1654 · Cited by 323
A Mitotic Septin Scaffold Required for Mammalian Chromosome Congression and Segregation
Spiliotis, E. T., Kinoshita, M., & Nelson, W. J. (2005) · Science · doi:10.1126/science.1106823 · Cited by 256
Cyclin-Dependent Kinases Control Septin Phosphorylation in Candida albicans Hyphal Development
Sinha, I., Wang, Y.-M., Philp, R., Li, C.-R., Yap, W. H., & Wang, Y. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.06.011 · Cited by 120
Three-dimensional ultrastructure of the septin filament network in Saccharomyces cerevisiae
Bertin, A., McMurray, M. A., Pierson, J., Thai, L., McDonald, K. L., Zehr, E. A., García, G., Peters, P., Thorner, J., & Nogales, E. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-10-0850 · Cited by 106
González-Novo, A., Correa-Bordes, J., Labrador, L., Sánchez, M., Vázquez de Aldana, C. R., & Jiménez, J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-09-0876 · Cited by 75
Metadata
- Authors
- Carroll, C. W., Altman, R., Schieltz, D., Yates, J. R., & Kellogg, D.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1998-11-02
- Volume
- 143
- Issue
- 3
- Pages
- 709-717
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2028234211
- Cited by
- 169
- References
- 1
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Carroll, C. W., Altman, R., Schieltz, D., Yates, J. R., & Kellogg, D. (1998). The Septins Are Required for the Mitosis-specific Activation of the Gin4 Kinase. The Journal of Cell Biology. https://doi.org/10.1083/jcb.143.3.709
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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