The DOI matches its Crossref record; 62 of the 63 references it cites were found in a registry or an index.
Telomere Length Dynamics and Chromosomal Instability in Cells Derived from Telomerase Null Mice
Open accessAbstract
To study the effect of continued telomere shortening on chromosome stability, we have analyzed the telomere length of two individual chromosomes (chromosomes 2 and 11) in fibroblasts derived from wild-type mice and from mice lacking the mouse telomerase RNA (mTER) gene using quantitative fluorescence in situ hybridization. Telomere length at both chromosomes decreased with increasing generations of mTER−/− mice. At the 6th mouse generation, this telomere shortening resulted in significantly shorter chromosome 2 telomeres than the average telomere length of all chromosomes. Interestingly, the most frequent fusions found in mTER−/− cells were homologous fusions involving chromosome 2. Immortal cultures derived from the primary mTER−/− cells showed a dramatic accumulation of fusions and translocations, revealing that continued growth in the absence of telomerase is a potent inducer of chromosomal instability. Chromosomes 2 and 11 were frequently involved in these abnormalities suggesting that, in the absence of telomerase, chromosomal instability is determined in part by chromosome-specific telomere length. At various points during the growth of the immortal mTER−/− cells, telomere length was stabilized in a chromosome-specific man-ner. This telomere-maintenance in the absence of telomerase could provide the basis for the ability of mTER−/− cells to grow indefinitely and form tumors.
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“In the G5-G6 TERCÀ/À tissues, there was clear cytogenetic evidence of progressive telomere erosion including 'signal-free' ends, chromosomal end-to-end fusions and anaphase bridging at mitosis (60)(61)(62).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [61]
In the citing paper
“G5-G6 TERC mice became infertile, showed high rates of apoptosis in testis and germ cell depletion, exhibited impaired bone marrow function and diminished proliferation of lymphocytes (61).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [61]
In the citing paper
“Indeed, continued breeding of first generation (G1) TERCÀ/À mice to yield successive generations of TERCÀ/À mice resulted in progressive loss of telomere reserves and ultimately provoked severe degeneration of highly proliferative tissues.”
From Telomeres and telomerase in cancer (2010) · cites this paper as [61]
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Citations
Cites
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · cited 1×
“Indeed, telomere shortening to a critical length has been proposed to limit the life span of somatic cells in humans (Harley et al., 1990; Counter et al., 1992).”
BackgroundExtension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975 · cited 2×
“It has been recently shown that the introduction of the telomerase catalytic subunit in primary human cells is sufficient to restore enzymatic activity, to elongate and maintain telomeres, and, in some cell types, to sustain immortal growth ( Bodnar et al., 1998; Wang et al., 1998; Kiyono et al., 1998).”
Structure and function of telomeres
Blackburn, E. H. (1991) · Nature · doi:10.1038/350569a0 · Cited by 3,596
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400 · cited 1×
“In such cells the enzyme telomerase seems to be the main mechanism for the maintenance of telomere length (Greider and Blackburn, 1985; Morin, 1989; Yu et al., 1990; Singer and Gottschling, 1994; McEachern and Blackburn, 1996; Nakamura et al., 1997).”
BackgroundA survey of telomerase activity in human cancer
Shay, J. W., & Bacchetti, S. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00062-2 · Cited by 2,794 · cited 1×
“These mechanisms, which can be either telomerase dependent (reviewed in Shay and Bacchetti, 1997 ) or independent (this paper and Bryan et al., 1995, 1997), can prevent telomeres from further shortening, allowing the immortal growth of cells that have critically short telomeres and a high degree of genetic instability.”
BackgroundTodaro, G. J., & Green, H. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.2.299 · Cited by 2,747 · cited 1×
“col (Todaro and Green, 1963) in dishes of 10 cm diam, seeding 10 6 cells ev-”
Telomerase Catalytic Subunit Homologs from Fission Yeast and Human
Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256
The RNA Component of Human Telomerase
Feng, J., Funk, W. D., Wang, S.-S., Weinrich, S. L., Avilion, A. A., Chiu, C.-P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., et al. (1995) · Science · doi:10.1126/science.7544491 · Cited by 2,227 · cited 2×
“, 1998), an RNA molecule that contains the template for the synthesis of telomeric repeats (Greider and Blackburn, 1989; Singer and Gottschling, 1994; Blasco et al., 1995; Feng et al., 1995; McEachern and Blackburn, 1995), and other associated proteins (Collins et al.”
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108 · cited 15×
“The details are explained elsewhere (Blasco et al., 1997).”
InfluentialSelf-citationCounter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096 · cited 1×
“Indeed, telomere shortening to a critical length has been proposed to limit the life span of somatic cells in humans (Harley et al., 1990; Counter et al., 1992).”
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Items 301–313 of 313
Real, A. P. J., & Murcia, N. P. (2012) · Minerva Digital Library (Universidad EAN)
Telomerasa: regulación, diana terapéutica y significado clínico en neoplasias humanas
Albanell, J. (2001) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
Exposure, telomere length, and cancer risk
Li, H. (2014) · Lund University Publications (Lund University)
Telomeres and Telomerase in Adrenocortical Carcinoma
Else, T., & Hornsby, P. J. (2009) · Springer eBooks · doi:10.1007/978-0-387-77236-3_13
“These chromosomal alterations can be observed in metaphase spreads of mouse embryonic fibroblasts from several shelterin-deficient animals [35, 54, 56–58].”
BackgroundTelomere Length Assessment in Human Archival
Meeker, A. K., Gage, W. R., Hicks, J. L., Simon, I., Coffman, J. R., Platz, E. A., March, G. E., & Marzo, A. M. D. (2002)
Chang, S. S. (2007) · Springer eBooks · doi:10.1007/978-3-540-73709-4_4
Telomere dynamics and telomerase-independent cell survival in Arabidopsis thaliana
Watson, J. M. (2009) · OakTrust (Texas A&M University Libraries)
Jasti, M. (2009) · OakTrust (Texas A&M University Libraries)
Tissue Architecture Is Required for Chromosome Segregation Fidelity in Epithelia
Knouse, K. A. (2018) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
Telomerase-Deficient Mouse Model
Samper, E., & Blasco, M. A. (2003) · CRC Press eBooks · doi:10.1201/9780203911709.ch22
Self-citationImplication du système télomères/télomerase au cours de la mastocytose
Georgin‐Lavialle, S. (2011) · theses.fr (ABES) · doi:10.70675/7de7d9a4z35a6z4313z8cf3z261ec926493e · Cited by 1
Senescence Signatures of Human Hematopoietic Stem Cells
Zimmermann, S., & Martens, U. M. (2007) · Springer eBooks · doi:10.1007/978-3-540-73709-4_7
Metadata
- Authors
- Hande, M. P., Samper, E., Lansdorp, P., & Blasco, M. A.
- Affiliations
- University of British Columbia (CA)
- *Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Campus Cantoblanco, Madrid E-28049, Spain; ‡Terry Fox Laboratory, British Columbia Cancer Research Center, Vancouver, British Columbia V5Z 1L3, Canada; and §Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1999-02-22
- Volume
- 144
- Issue
- 4
- Pages
- 589-601
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2132934
- OpenAlex
- W2110286112
- Cited by
- 313
- References
- 63
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 1 · 2020: 1 · 2019: 6 · 2018: 7 · 2017: 5 · 2016: 10 · 2015: 8 · 2014: 8 · 2013: 10 · 2012: 7
- FWCI
- 16.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Cell Biology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r01gm056162-01)
- National Cancer Institute (P01CA013106)
- National Institute of General Medical Sciences (GM56162)
- National Institute of Allergy and Infectious Diseases (R01AI029524)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Keywords
- telomere length, chromosomal instability, telomerase RNA, telomere shortening, chromosome 2, chromosome 11, translocation, cell immortalization, fibroblasts, tumor formation, telomere maintenance
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Cells, Cultured, Chromosome Aberrations, Models, Genetic, Neoplasms, Experimental, Telomere, In Situ Hybridization, Fluorescence, Mice, Knockout, Telomerase, Mice
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