The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Left-Right Asymmetry and Kinesin Superfamily Protein KIF3A: New Insights in Determination of Laterality and Mesoderm Induction by kif3A−/− Mice Analysis
Open accessAbstract
KIF3A is a classical member of the kinesin superfamily proteins (KIFs), ubiquitously expressed although predominantly in neural tissues, and which forms a heterotrimeric KIF3 complex with KIF3B or KIF3C and an associated protein, KAP3. To elucidate the function of the kif3A gene in vivo, we made kif3A knockout mice. kif3A−/− embryos displayed severe developmental abnormalities characterized by neural tube degeneration and mesodermal and caudal dysgenesis and died during the midgestational period at ∼10.5 dpc (days post coitum), possibly resulting from cardiovascular insufficiency. Whole mount in situ hybridization of Pax6 revealed a normal pattern while staining by sonic hedgehog (shh) and Brachyury (T) exhibited abnormal patterns in the anterior-posterior (A-P) direction at both mesencephalic and thoracic levels. These results suggest that KIF3A might be involved in mesodermal patterning and in turn neurogenesis.
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Cites
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Metadata
- Authors
- Takeda, S., Yonekawa, Y., Tanaka, Y., Okada, Y., Nonaka, S., & Hirokawa, N.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1999-05-17
- Volume
- 145
- Issue
- 4
- Pages
- 825-836
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2112331825
- Cited by
- 438
- References
- 46
- FWCI
- 8.16
- Type
- journal article
- Language
- en
- Open access
- green
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- Takeda, S., Yonekawa, Y., Tanaka, Y., Okada, Y., Nonaka, S., & Hirokawa, N. (1999). Left-Right Asymmetry and Kinesin Superfamily Protein KIF3A: New Insights in Determination of Laterality and Mesoderm Induction by kif3A−/− Mice Analysis. The Journal of Cell Biology. https://doi.org/10.1083/jcb.145.4.825
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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