The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
DNA Methyltransferase Is Actively Retained in the Cytoplasm during Early Development
Open accessAbstract
The overall DNA methylation level sharply decreases from the zygote to the blastocyst stage despite the presence of high levels of DNA methyltransferase (Dnmt1). Surprisingly, the enzyme is localized in the cytoplasm of early embryos despite the presence of several functional nuclear localization signals. We mapped a region in the NH2-terminal, regulatory domain of Dnmt1 that is necessary and sufficient for cytoplasmic retention during early development. Altogether, our results suggest that Dnmt1 is actively retained in the cytoplasm, which prevents binding to its DNA substrate in the nucleus and thereby contributes to the erasure of gamete-specific epigenetic information during early mammalian development.
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Cites
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
Transcription of IAP endogenous retroviruses is constrained by cytosine methylation
Walsh, C. P., Chaillet, J. R., & Bestor, T. H. (1998) · Nature Genetics · doi:10.1038/2413 · Cited by 1,105
Cited by
Genomic Imprinting Disrupted by a Maternal Effect Mutation in the Dnmt1 Gene
Howell, C. Y., Bestor, T. H., Ding, F., Latham, K. E., Mertineit, C., Trasler, J. M., & Chaillet, J. R. (2001) · Cell · doi:10.1016/s0092-8674(01)00280-x · Cited by 688
Regulation and function of DNA methylation in plants and animals
He, X.-J., Chen, T., & Zhu, J.-K. (2011) · Cell Research · doi:10.1038/cr.2011.23 · Cited by 555
DNA methylation and chromatin – unraveling the tangled web
Robertson, K. D. (2002) · Oncogene · doi:10.1038/sj.onc.1205609 · Cited by 471
Reconfiguration of DNA methylation in aging
Zampieri, M., Ciccarone, F., Calabrese, R., Franceschi, C., Bürkle, A., & Caiafa, P. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.02.002 · Cited by 254
“…including down-regulation of DNMT enzymes (Oda et al., 2013; Reichard et al., 2007; Zampieri et al., 2009), cytosolic localization of DNMT (Cardoso and Leonhardt, 1999; Jurkowska et al., 2011), impairment of DNMT recruitment on DNA (Bostick et al., 2007; Oda et al., 2013), decrease of the…”
BackgroundEpigenetic Inheritance: Concepts, Mechanisms and Perspectives
Lacal, I., & Ventura, R. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00292 · Cited by 258
Metadata
- Authors
- Cardoso, M. C., & Leonhardt, H.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1999-10-04
- Volume
- 147
- Issue
- 1
- Pages
- 25-32
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2168980816
- Cited by
- 172
- References
- 2
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cardoso, M. C., & Leonhardt, H. (1999). DNA Methyltransferase Is Actively Retained in the Cytoplasm during Early Development. The Journal of Cell Biology. https://doi.org/10.1083/jcb.147.1.25
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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