The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Docking Stage of Yeast Vacuole Fusion Requires the Transfer of Proteins from a Cis-Snare Complex to a Rab/Ypt Protein
Open accessAbstract
The homotypic fusion of yeast vacuoles requires Sec18p (NSF)-driven priming to allow vacuole docking, but the mechanism that links priming and docking is unknown. We find that a large multisubunit protein called the Vam2/6p complex is bound to cis-paired SNAP receptors (SNAREs) on isolated vacuoles. This association of the Vam2/6p complex with the cis-SNARE complex is disrupted during priming. The Vam2/6p complex then binds to Ypt7p, a guanosine triphosphate binding protein of the Rab family, to initiate productive contact between vacuoles. Thus, cis-SNARE complexes can contain Rab/Ypt effectors, and these effectors can be mobilized by NSF/Sec18p-driven priming, allowing their direct association with a Rab/Ypt protein to activate docking.
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Citations
Cites
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417 · cited 1×
“The core of this and other SNARE complexes is undoubtedly composed of a four-helix bundle (Katz et al., 1998; Poirier et al., 1998; Sutton et al., 1998) with a t-SNARE, v-SNARE, and s-SNARE.”
The Rab5 effector EEA1 is a core component of endosome docking
Christoforidis, S., McBride, H. M., Burgoyne, R. D., & Zerial, M. (1999) · Nature · doi:10.1038/17618 · Cited by 854
McBride, H. M., Rybin, V., Murphy, C., Giner, A., Teasdale, R., & Zerial, M. (1999) · Cell · doi:10.1016/s0092-8674(00)81966-2 · Cited by 520
Cited by
Rab proteins as membrane organizers
Zerial, M., & McBride, H. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052055 · Cited by 3,381
Role of Rab GTPases in Membrane Traffic and Cell Physiology
Hutagalung, A. H., & Novick, P. J. (2011) · Physiological Reviews · doi:10.1152/physrev.00059.2009 · Cited by 1,460
Rabs and their effectors: achieving specificity in membrane traffic
Grosshans, B. L., Ortiz, D., & Novick, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601617103 · Cited by 1,005
Wurmser, A. E., Sato, T. K., & Emr, S. D. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.3.551 · Cited by 425
Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion
Allan, B. B., Moyer, B. D., & Balch, W. E. (2000) · Science · doi:10.1126/science.289.5478.444 · Cited by 418
Metadata
- Authors
- Price, A., Seals, D., Wickner, W., & Ungermann, C.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2000-03-20
- Volume
- 148
- Issue
- 6
- Pages
- 1231-1238
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2045466386
- Cited by
- 206
- References
- 3
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Price, A., Seals, D., Wickner, W., & Ungermann, C. (2000). The Docking Stage of Yeast Vacuole Fusion Requires the Transfer of Proteins from a Cis-Snare Complex to a Rab/Ypt Protein. The Journal of Cell Biology. https://doi.org/10.1083/jcb.148.6.1231
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