The Role of Intraorganellar Ca2+In Late Endosome–Lysosome Heterotypic Fusion and in the Reformation of Lysosomes from Hybrid Organelles
Pryor, Paul R., Mullock, Barbara M., Bright, Nicholas A., Gray, Sally R., Luzio, J. Paul·2000·The Journal of Cell Biology
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- The Lysosome and Intracellular Signalling.G. Hesketh, L. Wartosch, Luther J. Davis, Nicholas A. Bright, J. P. Luzio · 2018 · Progress in molecular and subcellular biology
- Mucolipidosis Type IV: The Effect of Increased Lysosomal pH on the Abnormal Lysosomal StorageAviram Kogot‐Levin, Marsha Zeigler, Asher Ornoy, Gideon Bach · 2009 · Pediatric Research
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- Caenorhabditis elegans as a model for lysosomal storage disordersGert de Voer, Dorien J.M. Peters, Peter E.M. Taschner · 2008 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
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