Syntaxin 7 Complexes with Mouse Vps10p Tail Interactor 1b, Syntaxin 6, Vesicle-associated Membrane Protein (VAMP)8, and VAMP7 in B16 Melanoma Cells
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Syntaxin 7 is a mammalian target soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) involved in membrane transport between late endosomes and lysosomes. The aim of the present study was to use immunoaffinity techniques to identify proteins that interact with Syntaxin 7. We reasoned that this would be facilitated by the use of cells producing high levels of Syntaxin 7. Screening of a large number of tissues and cell lines revealed that Syntaxin 7 is expressed at very high levels in B16 melanoma cells. Moreover, the expression of Syntaxin 7 increased in these cells as they underwent melanogenesis. From a large scale Syntaxin 7 immunoprecipitation, we have identified six polypeptides using a combination of electrospray mass spectrometry and immunoblotting. These polypeptides corresponded to Syntaxin 7, Syntaxin 6, mouse Vps10p tail interactor 1b (mVti1b), alpha-synaptosome-associated protein (SNAP), vesicle-associated membrane protein (VAMP)8, VAMP7, and the protein phosphatase 1M regulatory subunit. We also observed partial colocalization between Syntaxin 6 and Syntaxin 7, between Syntaxin 6 and mVti1b, but not between Syntaxin 6 and the early endosomal t-SNARE Syntaxin 13. Based on these and data reported previously, we propose that Syntaxin 7/mVti1b/Syntaxin 6 may form discrete SNARE complexes with either VAMP7 or VAMP8 to regulate fusion events within the late endosomal pathway and that these events may play a critical role in melanogenesis.
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This complex brings endosomes/phagosomes in close proximity as a prerequisite for fusion, probably involving VAMP7 and 8.
“This complex brings endosomes/phagosomes in close proximity as a prerequisite for fusion (probably involving VAMP7 and 8) (35, 36).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [35]
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SNAP receptors implicated in vesicle targeting and fusion
Söllner, T. H., Whiteheart, S. W., Brunner, M., Erdjument‐Bromage, H., Geromanos, S. J., Tempst, P., & Rothman, J. E. (1993) · Nature · doi:10.1038/362318a0 · Cited by 3,239 · see citing works
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417 · see citing works
Yates, J. R., Eng, J. K., McCormack, A. L., & Schieltz, D. M. (1995) · Analytical Chemistry · doi:10.1021/ac00104a020 · Cited by 1,254 · see citing works
Compartmental specificity of cellular membrane fusion encoded in SNARE proteins
McNew, J. A., Parlati, F., Fukuda, R., Johnston, R. J., Paz, K., Paumet, F., Söllner, T. H., & Rothman, J. E. (2000) · Nature · doi:10.1038/35025000 · Cited by 691 · see citing works
The syntaxin family of vesicular transport receptors
Bennett, M. K., Garcia-Arrarás, J., Elferink, L. A., Peterson, K., Fleming, A. M., Hazuka, C. D., & Scheller, R. H. (1993) · Cell · doi:10.1016/0092-8674(93)90466-4 · Cited by 649 · see citing works
Dell’Angelica, E. C., Mullins, C., Caplan, S., & Bonifacino, J. S. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.10.1265 · Cited by 503 · see citing works
A mutation in Rab27a causes the vesicle transport defects observed in ashen mice
Wilson, S. M., Yip, R., Swing, D. A., O’Sullivan, T. N., Zhang, Y., Novak, E. K., Swank, R. T., Russell, L. B., Copeland, N. G., & Jenkins, N. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.140212797 · Cited by 406 · see citing works
Pryor, P. R., Mullock, B. M., Bright, N. A., Gray, S. R., & Luzio, J. P. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.5.1053 · Cited by 347 · see citing works
Self-citationGalli, T., Zahraoui, A., Vaidyanathan, V. V., Raposo, G., Tian, J. M., Karin, M., Niemann, H., & Louvard, D. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.6.1437 · Cited by 313 · see citing works
Syntaxin 6 functions in trans-Golgi network vesicle trafficking.
Bock, J. B., Klumperman, J., Davanger, S., & Scheller, R. H. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.7.1261 · Cited by 288 · see citing works
Topological restriction of SNARE-dependent membrane fusion
Parlati, F., McNew, J. A., Fukuda, R., Miller, R. B., Söllner, T. H., & Rothman, J. E. (2000) · Nature · doi:10.1038/35025076 · Cited by 287 · see citing works
Syntaxin 13 Mediates Cycling of Plasma Membrane Proteins via Tubulovesicular Recycling Endosomes
Prekeris, R., Klumperman, J., Chen, Y. A., & Scheller, R. H. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.4.957 · Cited by 286 · see citing works
SNAP family of NSF attachment proteins includes a brain-specific isoform
Whiteheart, S. W., Griff, I. C., Brunner, M., Clary, D. O., Mayer, T. U., Buhrow, S. A., & Rothman, J. E. (1993) · Nature · doi:10.1038/362353a0 · Cited by 275 · see citing works
Functional architecture of an intracellular membrane t-SNARE
Fukuda, R., McNew, J. A., Weber, T., Parlati, F., Engel, T., Nickel, W., Rothman, J. E., & Söllner, T. H. (2000) · Nature · doi:10.1038/35025084 · Cited by 245 · see citing works
von Mollard, G. F., Nothwehr, S. F., & Stevens, T. H. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.7.1511 · Cited by 216 · see citing works
Characterization of Munc-18c and Syntaxin-4 in 3T3-L1 Adipocytes
Tellam, J., Macaulay, S. L., McIntosh, S. R., Hewish, D. R., Ward, C. W., & James, D. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6179 · Cited by 210 · see citing works
Self-citationVamp-7 Mediates Vesicular Transport from Endosomes to Lysosomes
Advani, R. J., Yang, B., Prekeris, R., Lee, K. C., Klumperman, J., & Scheller, R. H. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.4.765 · Cited by 206 · see citing works
BAP-135, a target for Bruton’s tyrosine kinase in response to B cell receptor engagement
Yang, W., & Desiderio, S. V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.604 · Cited by 178 · see citing works
Mullock, B. M., Smith, C. W., Ihrke, G., Bright, N. A., Lindsay, M. R., Parkinson-Lawrence, E. J., Brooks, D. A., Parton, R. G., James, D. E., Luzio, J. P., et al. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.9.3137 · Cited by 164 · see citing works
Self-citationControl of the Terminal Step of Intracellular Membrane Fusion by Protein Phosphatase 1
Peters, C., Andrews, P. D., Stark, M. J. R., Cesaro-Tadic, S., Glatz, A., Podtelejnikov, A., Mann, M., & Mayer, A. (1999) · Science · doi:10.1126/science.285.5430.1084 · Cited by 160 · see citing works
SNAREs and the Secretory Pathway—Lessons from Yeast
Pelham, H. R. B. (1999) · Experimental Cell Research · doi:10.1006/excr.1998.4356 · Cited by 157 · see citing works
The R-SNARE Endobrevin/VAMP-8 Mediates Homotypic Fusion of Early Endosomes and Late Endosomes
Antonin, W., Holroyd, C., Tikkanen, R., Höning, S., & Jahn, R. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.10.3289 · Cited by 156 · see citing works
von Mollard, G. F., & Stevens, T. H. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.6.1719 · Cited by 154 · see citing works
A model for structural similarity between different SNARE complexes based on sequence relationships
Weimbs, T., Mostov, K. E., Low, S. H., & Hofmann, K. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01285-9 · Cited by 153 · see citing works
Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis
Martı́n-Martı́n, B., Nabokina, S. M., Blasi, J., Lazo, P. A., & Mollinedo, F. (2000) · Blood · doi:10.1182/blood.v96.7.2574 · Cited by 141 · see citing works
Ward, D. M., Pevsner, J., Scullion, M. A., Vaughn, M. B., & Kaplan, J. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.7.2327 · Cited by 139 · see citing works
Regulation of Melanosome Movement in the Cell Cycle by Reversible Association with Myosin V
Rogers, S. L., Karcher, R. L., Roland, J. T., Minin, A. А., Steffen, W., & Gelfand, V. I. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.6.1265 · Cited by 131 · see citing works
Sammak, P. J., Adams, S., Harootunian, A. T., Schliwa, M., & Tsien, R. Y. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.117.1.57 · Cited by 128 · see citing works
Chen, Y. H., Chen, M. X., Alessi, D. R., Campbell, D. G., Shanahan, C. M., Cohen, P., & Cohen, P. T. W. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01231-8 · Cited by 125 · see citing works
Wong, S. H., Zhang, T., Xu, Y., Subramaniam, V. N., Griffiths, G. W., & Hong, W. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.6.1549 · Cited by 115 · see citing works
The SNARE Vti1a-β Is Localized to Small Synaptic Vesicles and Participates in a Novel SNARE Complex
Antonin, W., Riedel, D., & von Mollard, G. F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-05724.2000 · Cited by 113 · see citing works
Tlg2p, a Yeast Syntaxin Homolog That Resides on the Golgi and Endocytic Structures
Abeliovich, H., Grote, E., Novick, P., & Ferro‐Novick, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.19.11719 · Cited by 111 · see citing works
Characterization of a Novel Yeast SNARE Protein Implicated in Golgi Retrograde Traffic
Lupashin, V. V., Pokrovskaya, I. D., McNew, J. A., & Waters, M. G. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.12.2659 · Cited by 111 · see citing works
Coco, S., Raposo, G., Martı́nez-Arca, S., Fontaine, J., Takamori, S., Zahraoui, A., Jahn, R., Matteoli, M., Louvard, D., & Galli, T. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-22-09803.1999 · Cited by 110 · see citing works
Moritz, R. L., Eddes, J. S., Reid, G. E., & Simpson, R. J. (1996) · Electrophoresis · doi:10.1002/elps.1150170512 · Cited by 103 · see citing works
Self-citationSyntaxin 7 Mediates Endocytic Trafficking to Late Endosomes
Nakamura, N., Yamamoto, A., Wada, Y., & Futai, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.9.6523 · Cited by 101 · see citing works
Rat Basophilic Leukemia Cells Express Syntaxin-3 and VAMP-7 in Granule Membranes
Hibi, T., Hirashima, N., & Nakanishi, M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2591 · Cited by 99 · see citing works
Bock, J. B., & Scheller, R. H. (1997) · Nature · doi:10.1038/387133a0 · Cited by 98 · see citing works
Nascimento, A. A. C., Amaral, R. G., Bizário, J. C. S., Larson, R. E., & Espreáfico, E. M. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.10.1971 · Cited by 90 · see citing works
Watson, R. T., & Pessin, J. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1261 · Cited by 65 · see citing works
Tang, B. L., Low, D. Y. H., Lee, S. S., Tan, A. E. H., & Hong, W. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.8029 · Cited by 64 · see citing works
von Mollard, G. F., & Stevens, T. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.2624 · Cited by 60 · see citing works
Preferential association of syntaxin 8 with the early endosome
Subramaniam, V. N., Loh, E., Horstmann, H., Habermann, A., Xu, Y., Coe, J. G. S., Griffiths, G. W., & Hong, W. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.6.997 · Cited by 53 · see citing works
Myosin-V is present in synaptosomes from rat cerebral cortex.
Mani, F., Espreáfico, E. M., & Larson, R. E. (1994) · PubMed · Cited by 18 · see citing works
Ota, Park, & Jimbow (1998) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1998.02356.x · Cited by 7 · see citing works
Flagged first, then by citations
1 of the 46 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Yang, W., and Desiderio, S. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 604 -609
- Wilson, S. M., Yip, R., Swing, D. A., O'Sullivan, T. N., Zhang, Y., Novak, E. K., Swant, R. T., Russell, L. B., Copeland, N. G., and Jenkins, N. A.. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 7933-7938
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Weiss, G., & Schaible, U. E. (2015) · Immunological Reviews · doi:10.1111/imr.12266 · Cited by 989 · see citing works
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies
Flannagan, R. S., Cosío, G., & Grinstein, S. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2128 · Cited by 947 · see citing works
Melanosomes — dark organelles enlighten endosomal membrane transport
Raposo, G., & Marks, M. S. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2258 · Cited by 587 · see citing works
Phagocytosis: A Fundamental Process in Immunity
Rosales, C., & Uribe‐Querol, E. (2017) · BioMed Research International · doi:10.1155/2017/9042851 · Cited by 562 · see citing works
Functions of Adaptor Protein (AP)-3 and AP-1 in Tyrosinase Sorting from Endosomes to Melanosomes
Theos, A. C., Tenza, D., Martina, J. A., Hurbain, I., Peden, A. A., Sviderskaya, E. V., Stewart, A., Robinson, M. S., Bennett, D. C., Cutler, D. F., et al. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0626 · Cited by 273 · see citing works
Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events
Pryor, P. R., Mullock, B. M., Bright, N. A., Lindsay, M. R., Gray, S. R., Richardson, S. C. W., Stewart, A., James, D. E., Piper, R. C., & Luzio, J. P. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400150 · Cited by 266 · see citing works
Self-citationSanderfoot, A. A., Kovaleva, V., Bassham, D. C., & Raikhel, N. V. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.12.3733 · Cited by 258 · see citing works
The Quest for the Mechanism of Melanin Transfer
Bossche, K. V. D., Naeyaert, J., & Lambert, J. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00425.x · Cited by 246 · see citing works
Late Endosomes: Sorting and Partitioning in Multivesicular Bodies
Piper, R. C., & Luzio, J. P. (2001) · Traffic · doi:10.1034/j.1600-0854.2001.20904.x · Cited by 215 · see citing works
Self-citationShewan, A. M., van Dam, E. M., Martin, S., Luen, T., Hong, W., Bryant, N. J., & James, D. E. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-06-0315 · Cited by 210 · see citing works
Self-citationA Role of VAMP8/Endobrevin in Regulated Exocytosis of Pancreatic Acinar Cells
Wang, C.-C., Ng, C. P., Lü, L., Atlashkin, V., Zhang, W., Seet, L., & Hong, W. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.08.002 · Cited by 172 · see citing works
Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators
ROSSI, V., Banfield, D. K., Vacca, M., Dietrich, L. E. P., Ungermann, C., D’Esposito, M., Galli, T., & Filippini, F. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.10.002 · Cited by 165 · see citing works
Raposo, G., & Marks, M. S. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.030401.x · Cited by 161 · see citing works
Membrane dynamics and the biogenesis of lysosomes (Review)
Luzio, J. P., Poupon, V., Lindsay, M. R., Mullock, B. M., Piper, R. C., & Pryor, P. R. (2003) · Molecular Membrane Biology · doi:10.1080/0968768031000089546 · Cited by 153 · see citing works
Self-citationMultiple roles of the vesicular‐SNARE TI‐VAMP in post‐Golgi and endosomal trafficking
Chaineau, M., Danglot, L., & Galli, T. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.10.026 · Cited by 149 · see citing works
Phagosome Maturation: A Few Bugs in the System
Scott, C. C., Botelho, R. J., & Grinstein, S. (2003) · The Journal of Membrane Biology · doi:10.1007/s00232-002-2008-2 · Cited by 138 · see citing works
Murray, R. Z., Wylie, F. G., Khromykh, T., Hume, D. A., & Stow, J. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414420200 · Cited by 157 · see citing works
Xu, Y., Martin, S., James, D. E., & Hong, W. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-01-0004 · Cited by 128 · see citing works
Self-citationRichardson, S. C. W., Winistorfer, S. C., Poupon, V., Luzio, J. P., & Piper, R. C. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-06-0358 · Cited by 127 · see citing works
Self-citationDeletion of the SNARE vti1b in Mice Results in the Loss of a Single SNARE Partner, Syntaxin 8
Atlashkin, V., Kreykenbohm, V., Eskelinen, E., Wenzel, D., Fayyazi, A., & von Mollard, G. F. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5198-5207.2003 · Cited by 123 · see citing works
What is the role of SNARE proteins in membrane fusion?
Duman, J. G., & Forte, J. G. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00091.2003 · Cited by 121 · see citing works
Melanosome Biogenesis in the Pigmentation of Mammalian Skin
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Syntaxin 6: The Promiscuous Behaviour of a SNARE Protein
Wendler, F., & Tooze, S. A. (2001) · Traffic · doi:10.1034/j.1600-0854.2001.20903.x · Cited by 117 · see citing works
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Roles of BLOC-1 and Adaptor Protein-3 Complexes in Cargo Sorting to Synaptic Vesicles
Litwa, K., Salazar, G., Smith, Y., & Faúndez, V. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-05-0456 · Cited by 94 · see citing works
Dennis, M. K., Delevoye, C., Acosta-Ruiz, A., Hurbain, I., Romao, M., Hesketh, G. G., Goff, P. S., Sviderskaya, E. V., Bennett, D. C., Luzio, J. P., et al. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201605090 · Cited by 92 · see citing works
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Nakamura, N., Fukuda, H., Kato, A., & Hirose, S. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-03-0216 · Cited by 88 · see citing works
Alberts, P., Rudge, R. E., Hinners, I., Muzerelle, A., Martı́nez-Arca, S., Irinopoulou, T., Marthiens, V., Tooze, S. A., Rathjen, F. G., Gaspar, P., et al. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-03-0147 · Cited by 86 · see citing works
Hasegawa, H., Zinsser, S., Rhee, Y., Vik-Mo, E. O., Davanger, S., & Hay, J. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-09-0556 · Cited by 85 · see citing works
Vesicular traffic in cell navigation
Zylbersztejn, K., & Galli, T. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08168.x · Cited by 82 · see citing works
Variations in the requirement for v-SNAREs in GLUT4 trafficking in adipocytes
Zhao, P., Lü, Y., Lopez, J. A., Fan, J., Burchfield, J. G., Bai, L., Hong, W., Xu, T., & James, D. E. (2009) · Journal of Cell Science · doi:10.1242/jcs.047449 · Cited by 82 · see citing works
Self-citationProux‐Gillardeaux, V., Rudge, R. E., & Galli, T. (2005) · Traffic · doi:10.1111/j.1600-0854.2005.00288.x · Cited by 78 · see citing works
Meng, J., & Wang, J.-F. (2015) · Biochimica et Biophysica Acta · doi:10.1016/j.bbcan.2015.04.002 · Cited by 70 · see citing works
Misura, K. M. S., Gonzalez, L. C., May, A. P., Scheller, R. H., & Weis, W. I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106853200 · Cited by 69 · see citing works
Lapierre, L. A., Avant, K. M., Caldwell, C. M., Ham, A. L., Hill, S., Williams, J. A., Smolka, A. J., & Goldenring, J. R. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00505.2006 · Cited by 64 · see citing works
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BOGDANOVIC, A., Bennett, N., Kieffer‐Jaquinod, S., Louwagie, M., Morio, T., Garin, J., Satre, M., & Brückert, F. (2002) · Biochemical Journal · doi:10.1042/bj20020845 · Cited by 62 · see citing works
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Ullmann, P., Qureshi-Baig, K., Rodriguez, F., Ginolhac, A., Nonnenmacher, Y., Ternes, D., Weiler, J., Gäbler, K., Bahlawane, C., Hiller, K., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11772 · Cited by 60 · see citing works
Richardson, S. C. W., Wallom, K., Ferguson, E. L., Deacon, S. P. E., Davies, M. W., Powell, A. J., Piper, R. C., & Duncan, R. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.12.015 · Cited by 57 · see citing works
Self-citationThree-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog
Misura, K. M. S., Bock, J. B., Gonzalez, L. C., Scheller, R. H., & Weis, W. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132274599 · Cited by 54 · see citing works
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Vats, S., & Galli, T. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.884020 · Cited by 51 · see citing works
Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16
Wang, Y., Tai, G., Lü, L., Johannes, L., Hong, W., & Tang, B. L. (2005) · Molecular Membrane Biology · doi:10.1080/09687860500143829 · Cited by 48 · see citing works
Oxidized phagosomal NOX2 complex is replenished from lysosomes
Dingjan, I., Linders, P. T. A., van den Bekerom, L., Baranov, M. V., Halder, P., ter Beest, M., & van den Bogaart, G. (2017) · Journal of Cell Science · doi:10.1242/jcs.196931 · Cited by 47 · see citing works
Ectopic expression of syntaxin 1 in the ER redirects TI-VAMP- and cellubrevin-containing vesicles
Martı́nez-Arca, S., Proux‐Gillardeaux, V., Alberts, P., Louvard, D., & Galli, T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00467 · Cited by 45 · see citing works
Suzuki, J., Ohnishi, H., Wada, A., Hirayama, T., Ohno, H., Ueda, N., Yasuda, H., Iiri, T., Wada, Y., Futai, M., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212445200 · Cited by 43 · see citing works
Zhang, Y., Shu, L., & Chen, X. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801711200 · Cited by 40 · see citing works
Spatial organization of lysosomal exocytosis relies on membrane tension gradients
Lachuer, H., Le, L., Lévêque‐Fort, S., Goud, B., & Schauer, K. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2207425120 · Cited by 33 · see citing works
Martín-Gómez, L., Villalba, A., Carballal, M. J., & Abollo, E. (2013) · Gene · doi:10.1016/j.gene.2013.09.085 · Cited by 34 · see citing works
Over-expression of microRNA-1 causes arrhythmia by disturbing intracellular trafficking system
Su, X., Liang, H., Wang, H., Chen, G., Jiang, H., Wu, Q., Liu, T., Liu, Q., Yu, T., Gu, Y., et al. (2017) · Scientific Reports · doi:10.1038/srep46259 · Cited by 29 · see citing works
Bowman, S. L., Le, L., Zhu, Y., Harper, D. C., Sitaram, A., Theos, A. C., Sviderskaya, E. V., Bennett, D. C., Raposo, G., Owen, D. J., et al. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202005173 · Cited by 28 · see citing works
Mashima, H., Suzuki, J., Hirayama, T., Yoshikumi, Y., Ohno, H., Ohnishi, H., Yasuda, H., Fujita, T., & Omata, M. (2008) · Infection and Immunity · doi:10.1128/iai.01573-07 · Cited by 26 · see citing works
Selective Expression of Syntaxin-7 Protein in Benign Melanocytes and Malignant Melanoma
Strömberg, S., Agnarsdóttir, M., Magnusson, K., Rexhepaj, E., Bolander, Å., Lundberg, E. K., Asplund, A., Ryan, D., Rafferty, M., Gallagher, W. M., et al. (2009) · Journal of Proteome Research · doi:10.1021/pr800745e · Cited by 24 · see citing works
Genetic risk factors for Creutzfeldt-Jakob disease
Jones, E. L., & Mead, S. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104973 · Cited by 43 · see citing works
An Emerging Role for SNARE Proteins in Dendritic Cell Function
Collins, L. E., DeCourcey, J., Luca, M. D., Rochfort, K. D., & Loscher, C. E. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00133 · Cited by 22 · see citing works
Delevoye, C., Giordano, F., van Niel, G., & Raposo, G. (2011) · médecine/sciences · doi:10.1051/medsci/2011272153 · Cited by 21 · see citing works
Cueto, J. A., Vanrell, M. C., Salassa, B. N., Nola, S., Galli, T., Colombo, M. I., & Romano, P. S. (2016) · Cellular Microbiology · doi:10.1111/cmi.12713 · Cited by 16 · see citing works
Margiotta, A., Frei, D. M., Sendstad, I. H., Janssen, L., Neefjes, J., & Bakke, O. (2020) · Journal of Cell Science · doi:10.1242/jcs.244624 · Cited by 16 · see citing works
Syntaxin6 separates from GM1a-rich membrane microdomain during granule maturation
Katsumata, O., Fujita‐Yoshigaki, J., Hara‐Yokoyama, M., Yanagishita, M., Furuyama, S., & Sugiya, H. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.053 · Cited by 15 · see citing works
SNARE dynamics during melanosome maturation
Ohbayashi, N., & Fukuda, M. (2018) · Biochemical Society Transactions · doi:10.1042/bst20180130 · Cited by 11 · see citing works
Aspirin regulates SNARE protein expression and phagocytosis in dendritic cells
Cai, D. T., Ho, Y. H. S., Chiow, K. H., Wee, S. H., Han, Y., Peh, M. T., & Wong, S. H. (2011) · Molecular Membrane Biology · doi:10.3109/09687688.2010.525756 · Cited by 11 · see citing works
Delevoye, C., Giordano, F., Marks, M. S., & Raposo, G. (2011) · Melanins and Melanosomes · doi:10.1002/9783527636150.ch9 · Cited by 10 · see citing works
SNARE Proteins in Synaptic Vesicle Fusion
Palfreyman, M. T., West, S. E., & Jørgensen, E. M. (2023) · Advances in neurobiology · doi:10.1007/978-3-031-34229-5_4 · Cited by 10 · see citing works
SNAREs in the maturation and function of LROs
Jani, R. A., Mahanty, S., & Setty, S. R. G. (2016) · BioArchitecture · doi:10.1080/19490992.2015.1131890 · Cited by 8 · see citing works
VAMP8/Endobrevin is a critical factor for the homotypic granule growth in pancreatic acinar cells
Hammel, I., Wang, C.-C., Hong, W., & Amihai, D. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1400-1 · Cited by 7 · see citing works
Exocytic machineries differentially control mediator release from allergen-triggered RBL-2H3 cells
Adhikari, P., Ayo, T. E., Vines, J. C., Sugita, S., & Xu, H. (2023) · Inflammation Research · doi:10.1007/s00011-023-01698-z · Cited by 7 · see citing works
Intracellular location of syntaxin 7 in human neutrophils
Xie, L.-X., Calafat, J., Janssen, H., de la Iglesia-Vicente, J., & Mollinedo, F. (2010) · Immunology Letters · doi:10.1016/j.imlet.2010.02.003 · Cited by 7 · see citing works
Green fluorescent protein (GFP): is seeing believing and is that enough?
Shorter, S. A., Pettit, M. W., Dyer, P. D. R., Coakley-Youngs, E., Gorringe-Pattrick, M. A. M., El-Daher, S. S., & Richardson, S. C. W. (2017) · Journal of drug targeting · doi:10.1080/1061186x.2017.1358725 · Cited by 5 · see citing works
Physiologic Exocytosis in Pancreatic Acinar Cells and Pathologic Fusion Underlying Pancreatitis
Dolai, S. (2020) · doi:10.3998/panc.2020.04 · Cited by 5 · see citing works
Spotting genome-wide pigmentation variation in a brown trout admixture contextPreprint
Valette, T., Leitwein, M., LASCAUX, J. M., Desmarais, É., Berrebi, P., & Guinand, B. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.23.217109 · Cited by 4 · see citing works
Tracking Intracellular Polymer Localization Via Fluorescence Microscopy
Richardson, S. C. W. (2010) · doi:10.1002/9780470875780.ch10 · Cited by 3 · see citing works
Transport and Distribution of Melanosomes
Gele, M. V., & Lambert, J. (2011) · doi:10.1002/9783527636150.ch10 · Cited by 3 · see citing works
The clues offered by SNAREs on the vacuoles of plants and animals
Barozzi, F., Sampaio, M., Pereira, C., & Sansebastiano, G. P. D. (2025) · Frontiers in Plant Science · doi:10.3389/fpls.2025.1599323 · Cited by 2 · see citing works
Botulinum neurotoxin type DC (BoNT/DC) cleavage of VAMP3 reduces melanin production in melanocytes
Malik, S. Z., Le, L., Boissy, R. E., Brideau-Andersen, A. D., & Sondergaard, B. (2025) · Toxicon · doi:10.1016/j.toxicon.2025.108372 · Cited by 2 · see citing works
Characterisation of Vti1b and Vti1a proteins and generation of knock-out mice.
Atlachkine, V. (2002) · doi:10.53846/goediss-91 · Cited by 2 · see citing works
Membrane tension spatially organizes lysosomal exocytosisPreprint
Lachuer, H., Le, L., Lévêque‐Fort, S., Goud, B., & Schauer, K. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.22.489160 · Cited by 2 · see citing works
Lysosome Biogenesis and Dynamics
Ward, D. M., Shiflett, S. L., & Kaplan, J. (2007) · Springer eBooks · doi:10.1007/0-387-26867-7_6 · Cited by 1 · see citing works
Layani, A., Meningher, T., Sidi, Y., Avni, D., & Leibowitz‐Amit, R. (2025) · Cancers · doi:10.3390/cancers17132197 · Cited by 1 · see citing works
Galli, T., D’Esposito, M., & Sotirakis, E. (2006) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a003510.01 · Cited by 1 · see citing works
Prognostic Factors in Malignant Melanoma
Bolander, Å. (2008) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 1 · see citing works
Delevoye, C., Giordano, F., van Niel, G., & Raposo, G. (2011)
Regulation of SNARE proteins in macrophages by colony stimulating factor-1
Achuthan, A. A. (2007) · Minerva Access (University of Melbourne)
Identification and Characterization of the Interaction between VPS33B and SNAREs
Puhacz, M. (2011) · TSpace (University of Toronto)
Invariant chain regulates endosomal fusion and maturation through the SNARE Vti1bPreprint
Frei, D. M., Margiotta, A., Distefano, M. B., Moulefera, M. A., Janssen, L., Thibodeau, J., Neefjes, J., & Bakke, O. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/771857
Characterising the intracellular trafficking of matrix Metalloproteinase 14 in macrophages
West, Z. E. (2021) · Queensland University of Technology · doi:10.5204/thesis.eprints.213196
Hossain, M. R., Kimura-Sashikawa, M., & Komine, M. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.103943
- Authors
- Wade, N., Bryant, N. J., Connolly, L. M., Simpson, R. J., Luzio, J. P., Piper, R. C., & James, D. E.
- Affiliations
- The University of Queensland (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- University of Cambridge (GB)
- University of Iowa (US)
- Corresponding author
- James, David E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 276
- Issue
- 23
- Pages
- 19820-19827
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2002982584
- Cited by
- 89
- References
- 46
- Citations by year
- 2025: 3 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 4 · 2013: 1 · 2012: 2
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- Australian Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- syntaxin 7, Vti1b, syntaxin 6, VAMP8, VAMP7, SNARE complex, protein-protein interaction, melanogenesis, B16 melanoma, t-SNARE
- MeSH terms
- Amino Acid Sequence, Animals, Antibody Specificity, Carrier Proteins, Melanoma, Experimental, Membrane Proteins, Molecular Sequence Data, Precipitin Tests, Protein Binding, Tumor Cells, Cultured, R-SNARE Proteins, Qa-SNARE Proteins, Qb-SNARE Proteins, Mice
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