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Caveolin-2 Is Targeted to Lipid Droplets, a New “Membrane Domain” in the Cell
Open accessAbstract
Caveolin-1 and -2 constitute a framework of caveolae in nonmuscle cells. In the present study, we showed that caveolin-2, especially its β isoform, is targeted to the surface of lipid droplets (LD) by immunofluorescence and immunoelectron microscopy, and by subcellular fractionation. Brefeldin A treatment induced further accumulation of caveolin-2 along with caveolin-1 in LD. Analysis of mouse caveolin-2 deletion mutants revealed that the central hydrophobic domain (residues 87–119) and the NH2-terminal (residues 70–86) and COOH-terminal (residues 120–150) hydrophilic domains are all necessary for the localization in LD. The NH2- and COOH-terminal domains appeared to be related to membrane binding and exit from ER, respectively, implying that caveolin-2 is synthesized and transported to LD as a membrane protein. In conjunction with recent findings that LD contain unesterified cholesterol and raft proteins, the result implies that the LD surface may function as a membrane domain. It also suggests that LD is related to trafficking of lipid molecules mediated by caveolins.
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Citations
Cited by
Emerging Themes in Lipid Rafts and Caveolae
Galbiati, F., Razani, B., & Lisanti, M. P. (2001) · Cell · doi:10.1016/s0092-8674(01)00472-x · Cited by 567
Lipid droplets in inflammation and cancer
Bozza, P. T., & Viola, J. P. B. (2010) · Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) · doi:10.1016/j.plefa.2010.02.005 · Cited by 446
Thomsen, P., Roepstorff, K., Stahlhut, M., & van Deurs, B. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-06-0317 · Cited by 435
Imaging of Lipid Biosynthesis: How a Neutral Lipid Enters Lipid Droplets
Kuerschner, L., Moessinger, C., & Thiele, C. (2008) · Traffic · doi:10.1111/j.1600-0854.2007.00689.x · Cited by 411
Ozeki, S., Cheng, J., Tauchi-Sato, K., Hatano, N., Taniguchi, H., & Fujimoto, T. (2005) · Journal of Cell Science · doi:10.1242/jcs.02401 · Cited by 369
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Metadata
- Authors
- Fujimoto, T., Kogo, H., Ishiguro, K., Tauchi, K., & Nomura, R.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2001-03-05
- Volume
- 152
- Issue
- 5
- Pages
- 1079-1086
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2147963733
- Cited by
- 250
- References
- 0
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Fujimoto, T., Kogo, H., Ishiguro, K., Tauchi, K., & Nomura, R. (2001). Caveolin-2 Is Targeted to Lipid Droplets, a New “Membrane Domain” in the Cell. The Journal of Cell Biology. https://doi.org/10.1083/jcb.152.5.1079
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