Lipid droplets in inflammation and cancer

Bozza, Patricia T.; Viola, João P.B.

doi:10.1016/j.plefa.2010.02.005

Cited by 450Lipid metabolism and biosynthesisCancer, Lipids, and MetabolismFatty Acid Research and Health

Lipid droplets in inflammation and cancer

Bozza, Patricia T., Viola, João P.B.·2010·Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)

DOI 10.1016/j.plefa.2010.02.005

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Abstract

Accumulation of lipid droplets (also known as lipid bodies or adiposomes) within leukocytes, epithelial cells, hepatocytes and other non-adipocytic cells is a frequently observed phenotype in infectious, neoplastic and other inflammatory conditions. Lipid droplet biogenesis is a regulated cellular process that culminates in the compartmentalization of lipids and of an array of enzymes, protein kinases and other proteins, suggesting that lipid droplets are inducible organelles with roles in cell signaling, regulation of lipid metabolism, membrane trafficking and control of the synthesis and secretion of inflammatory mediators. Enzymes involved in eicosanoid synthesis are localized at lipid droplets and lipid droplets are sites for eicosanoid generation in cells during inflammation and cancer. In this review, we discuss the current evidence related to the biogenesis and function of lipid droplets in cell metabolism and signaling in inflammation and cancer. Moreover, the potential of lipid droplets as markers of disease and targets for novel anti-inflammatory and antineoplastic therapies will be discussed.

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Lipid droplets are production and storage sites for eicosanoids and inflammatory cytokines, and are involved in antigen presentation and pathogen clearance.
“Here, lipid droplets are production and storage sites for eicosanoids and inflammatory cytokines, and are further involved in antigen presentation and pathogen clearance9.”
From Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain (2020) · cites this paper as [9]
Myeloid cells form lipid droplets in response to inflammation and stress.
“Myeloid cells form lipid droplets in response to inflammation and stress, including the aforementioned macrophages in atherosclerotic lesions, leukocytes in inflammatory arthritis, and eosinophils in allergic inflammation.”
From Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain (2020) · cites this paper as [9]
In peripheral immune cells, lipid droplets form often as a response to inflammation and stress.
“In peripheral immune cells, lipid droplets form often as a response to inflammation and stress9.”
From Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain (2020) · cites this paper as [9]
Lipid droplets have also been correlated with beneficial functions, such as improved host defense and antigen cross presentation in myeloid cells.
“However, lipid droplets have also been correlated with beneficial functions, such as improved host defense and antigen cross presentation in myeloid cells9.”
From Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain (2020) · cites this paper as [9]
Metabolic changes towards increased fatty acid production cause lipid droplet formation in immune cells and cancer cells.
“Besides inflammation, metabolic changes towards increased fatty acid production have been reported to cause lipid droplet formation in immune cells9 and also in cancer cells41.”
From Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain (2020) · cites this paper as [9]

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Lipid bodies in oxidized LDL-induced foam cells are leukotriene-synthesizing organelles: a MCP-1/CCL2 regulated phenomenon
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Cytoplasmic lipid bodies of human neutrophilic leukocytes.
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Endogenous Platelet-Activating Factor Is Critically Involved in Effector Functions of Eosinophils Stimulated with IL-5 or IgG
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Prostaglandin Endoperoxide Synthase (Cyclooxygenase): Ultrastructural Localization to Nonmembrane-Bound Cytoplasmic Lipid Bodies in Human Eosinophils and 3T3 Fibroblasts
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Expression of Adipose Differentiation-Related Protein: A Predictor of Cancer-Specific Survival in Clear Cell Renal Carcinoma
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Enzymatically Degraded LDL Preferentially Binds to CD14 high CD16 + Monocytes and Induces Foam Cell Formation Mediated Only in Part by the Class B Scavenger-Receptor CD36
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IL-16 Promotes Leukotriene C4 and IL-4 Release from Human Eosinophils via CD4- and Autocrine CCR3-Chemokine-Mediated Signaling
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Cytosolic phospholipase A2-driven PGE2 synthesis within unsaturated fatty acids-induced lipid bodies of epithelial cells☆
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Cytoplasmic Lipid Bodies in Eosinophils: Central Roles in Eicosanoid Generation
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Lipid droplet and milk lipid globule membrane associated placental protein 17b (PP17b) is involved in apoptotic and differentiation processes of human epithelial cervical carcinoma cells
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Allergic Challenge–Elicited Lipid Bodies Compartmentalize In Vivo Leukotriene C4 Synthesis within Eosinophils
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Expression and Localization of Prostaglandin E Synthase Isoforms in Human Fetal Membranes in Term and Preterm Labor
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Ultrastructural Localization of Prostaglandin Endoperoxide Synthase (Cyclooxygenase) to Isolated, Purified Fractions of Guinea Pig Peritoneal Macrophage and Line 10 Hepatocarcinoma Cell Lipid Bodies
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Low-Density Lipoprotein From Apolipoprotein E-Deficient Mice Induces Macrophage Lipid Accumulation in a CD36 and Scavenger Receptor Class A-Dependent Manner
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Cutting Edge: Prostaglandin D2 Enhances Leukotriene C4 Synthesis by Eosinophils during Allergic Inflammation: Synergistic In Vivo Role of Endogenous Eotaxin
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Dynamics of Lipid Droplet-Associated Proteins during Hormonally Stimulated Lipolysis in Engineered Adipocytes: Stabilization and Lipid Droplet Binding of Adipocyte Differentiation-Related Protein/Adipophilin
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RNA is closely associated with human mast cell lipid bodies.
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Novel translocation responses of cytosolic phospholipase A2α fluorescent proteins
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Adipose Differentiation-Related Protein: A Gonadotropin- and Prostaglandin-Regulated Protein in Primate Periovulatory Follicles1
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Expression and Localization of Adipophilin and Perilipin in Human Fetal Membranes: Association with Lipid Bodies and Enzymes Involved in Prostaglandin Synthesis
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Induction of the lipocyte phenotype in murine hepatic stellate cells: reorganisation of the actin cytoskeleton
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Synergism Between Platelet-Activating Factor-Like Phospholipids and Peroxisome Proliferator-Activated Receptor γ Agonists Generated During Low Density Lipoprotein Oxidation That Induces Lipid Body Formation in Leukocytes
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Possible involvement of protein kinase C in the induction of adipose differentiation‐related protein by Sterol ester in RAW 264.7 macrophages
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NS-398: cyclooxygenase-2 independent inhibition of leukocyte priming for lipid body formation and enhanced leukotriene generation
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Mast Cell Secretory Granules and Lipid Bodies Contain the Necessary Machinery Important for the in situ Synthesis of Proteins
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Electron microscope immunocytochemical localization of cyclooxygenase-1 and -2 in pseudopregnant rat corpus luteum during luteolysis
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In vitro and in vivo localization of prostaglandin H synthase in fetal sheep neurons
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Cellular Fatty Acid Metabolism and Cancer
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Ultrabright and Fluorogenic Probes for Multicolor Imaging and Tracking of Lipid Droplets in Cells and Tissues
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HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma
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Bright Near-Infrared Aggregation-Induced Emission Luminogens with Strong Two-Photon Absorption, Excellent Organelle Specificity, and Efficient Photodynamic Therapy Potential
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Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators
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Lipid Droplets and the Management of Cellular Stress.
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Lipid Droplets: A New Player in Colorectal Cancer Stem Cells Unveiled by Spectroscopic Imaging
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An Overview of Lipid Droplets in Cancer and Cancer Stem Cells
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Lipid Droplets: A Key Cellular Organelle Associated with Cancer Cell Survival under Normoxia and Hypoxia
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Lipid droplet proteins and metabolic diseases
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Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases
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Protein Correlation Profiles Identify Lipid Droplet Proteins with High Confidence
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Three-dimensional label-free imaging and quantification of lipid droplets in live hepatocytes
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The life cycle of lipid droplets
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The expanded role of fatty acid metabolism in cancer: new aspects and targets
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Specific Fluorescence Probes for Lipid Droplets Based on Simple AIEgens
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Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: a putative mechanism for host lipid acquisition and bacterial survival in phagosomes
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Leukocyte lipid bodies — Biogenesis and functions in inflammation
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Authors: Bozza, P. T., & Viola, J. P. B.
Affiliations: Instituto Nacional de Câncer - INCA (BR)
ORCID: Viola, João P.B.
Venue: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
Publisher: Elsevier BV
Published: 2010-04
Volume: 82
Issue: 4-6
Pages: 243-250
ISSN: 0952-3278 (ISSN-L)
DOI: 10.1016/j.plefa.2010.02.005
OpenAlex: W2149056596
Cited by: 446
References: 116
Citations by year: 2026: 18 · 2025: 31 · 2024: 27 · 2023: 35 · 2022: 34 · 2021: 39 · 2020: 47 · 2019: 26 · 2018: 28 · 2017: 34 · 2016: 19 · 2015: 26 · 2014: 28 · 2013: 22 · 2012: 17
FWCI: 1.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Prostaglandins Leukotrienes and Essential Fatty Acids (publishedVersion)
PubMed (publishedVersion)
Arca - Repositório Institucional da Fiocruz (submittedVersion)
Funders: Institut National Du Cancer
Fundação Oswaldo Cruz
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords: lipid droplets, lipid droplet formation, inflammation, cancer, eicosanoid biosynthesis, lipid metabolism, signal transduction, membrane trafficking, leukocytes, inflammatory mediators, disease biomarkers, anti-inflammatory therapy, antineoplastic therapy
MeSH terms: Animals, Anti-Inflammatory Agents, Non-Steroidal, Humans, Inflammation, Leukocytes, Lipids, Neoplasms, Eicosanoids, Cytoplasmic Vesicles, Lipid Metabolism

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Lipid droplets in inflammation and cancer

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