The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Localization of Calmodulin and Dynein Light Chain Lc8 in Flagellar Radial Spokes
Open accessAbstract
Genetic and in vitro analyses have revealed that radial spokes play a crucial role in regulation of ciliary and flagellar motility, including control of waveform. However, the mechanisms of regulation are not understood. Here, we developed a novel procedure to isolate intact radial spokes as a step toward understanding the mechanism by which these complexes regulate dynein activity. The isolated radial spokes sediment as 20S complexes that are the size and shape of radial spokes. Extracted radial spokes rescue radial spoke structure when reconstituted with isolated axonemes derived from the radial spoke mutant pf14. Isolated radial spokes are composed of the 17 previously defined spoke proteins as well as at least five additional proteins including calmodulin and the ubiquitous dynein light chain LC8. Analyses of flagellar mutants and chemical cross-linking studies demonstrated calmodulin and LC8 form a complex located in the radial spoke stalk. We postulate that calmodulin, located in the radial spoke stalk, plays a role in calcium control of flagellar bending.
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Cites
Cole, D. G., Diener, D. R., Himelblau, A. L., Beech, P. L., Fuster, J. C., & Rosenbaum, J. L. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.4.993 · Cited by 898
Self-citation
Cited by
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Qin, H., Diener, D. R., Geimer, S., Cole, D. G., & Rosenbaum, J. L. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200308132 · Cited by 342
Self-citationFlagellar and ciliary beating: the proven and the possible
Lindemann, C. B., & Lesich, K. A. (2010) · Journal of Cell Science · doi:10.1242/jcs.051326 · Cited by 291
Sperm flagella: comparative and phylogenetic perspectives of protein components
Inaba, K. (2011) · Molecular Human Reproduction · doi:10.1093/molehr/gar034 · Cited by 287
Smith, E. F., & Yang, P. (2004) · Cell Motility · doi:10.1002/cm.10155 · Cited by 279
Self-citationMolecular Architecture of the Sperm Flagella: Molecules for Motility and Signaling
Inaba, K. (2003) · Zoological Science · doi:10.2108/zsj.20.1043 · Cited by 269
Metadata
- Authors
- Yang, P., Diener, D. R., Rosenbaum, J. L., & Sale, W. S.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2001-06-11
- Volume
- 153
- Issue
- 6
- Pages
- 1315-1326
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2150350177
- Cited by
- 187
- References
- 1
- FWCI
- 6.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Yang, P., Diener, D. R., Rosenbaum, J. L., & Sale, W. S. (2001). Localization of Calmodulin and Dynein Light Chain Lc8 in Flagellar Radial Spokes. The Journal of Cell Biology. https://doi.org/10.1083/jcb.153.6.1315
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
