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ELECTRON MICROSCOPY OF LYSOSOME-RICH FRACTIONS FROM RAT LIVER

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Novikoff, Alex B., Beaufay, H., de Duve, C.·1956·The Journal of Cell Biology

Abstract

A preliminary electron microscope study has revealed the presence in lysosome-rich fractions, isolated from rat liver, of hitherto undescribed cytoplasmic particles, called "dense bodies." Approximately 0.37 µ in length, the dense bodies often possess an internal cavity and external membrane. They contain many electron-dense granules 55 to 77 A, or less, in diameter. Such dense bodies are also visible in electron micrographs of parenchymatous cells in liver sections. The correlations between dense bodies and lysosomes are listed, but until pure preparations are available it is not possible to assert that dense bodies and lysosomes are identical.

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Metadata

Authors
Novikoff, A. B., Beaufay, H., & de Duve, C.
Venue
The Journal of Cell Biology
Published
1956-07-25
Volume
2
Issue
4
Pages
179-184
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
OpenAlex
W1995616301
Cited by
330
References
0
FWCI
17.47
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: ELECTRON MICROSCOPY OF LYSOSOME-RICH FRACTIONS FROM RAT LIVER. https://app.cochat.ai/papers/10.1083/jcb.2.4.179
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Novikoff, A. B., Beaufay, H., & de Duve, C. (1956). ELECTRON MICROSCOPY OF LYSOSOME-RICH FRACTIONS FROM RAT LIVER. The Journal of Cell Biology. https://doi.org/10.1083/jcb.2.4.179

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.