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ELECTRON MICROSCOPY OF LYSOSOME-RICH FRACTIONS FROM RAT LIVER
Open accessAbstract
A preliminary electron microscope study has revealed the presence in lysosome-rich fractions, isolated from rat liver, of hitherto undescribed cytoplasmic particles, called "dense bodies." Approximately 0.37 µ in length, the dense bodies often possess an internal cavity and external membrane. They contain many electron-dense granules 55 to 77 A, or less, in diameter. Such dense bodies are also visible in electron micrographs of parenchymatous cells in liver sections. The correlations between dense bodies and lysosomes are listed, but until pure preparations are available it is not possible to assert that dense bodies and lysosomes are identical.
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Cited by
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Ueno, T., & Komatsu, M. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.185 · Cited by 500
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Madeo, F., Zimmermann, A., Maiuri, M. C., & Kroemer, G. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73946 · Cited by 464
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Müller, T. D., Finan, B., Clemmensen, C., DiMarchi, R. D., & Tschöp, M. H. (2017) · Physiological Reviews · doi:10.1152/physrev.00025.2016 · Cited by 419
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Essner, E., & Novikoff, A. B. (1960) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(60)90016-2 · Cited by 351
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Metadata
- Authors
- Novikoff, A. B., Beaufay, H., & de Duve, C.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1956-07-25
- Volume
- 2
- Issue
- 4
- Pages
- 179-184
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1995616301
- Cited by
- 330
- References
- 0
- FWCI
- 17.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Novikoff, A. B., Beaufay, H., & de Duve, C. (1956). ELECTRON MICROSCOPY OF LYSOSOME-RICH FRACTIONS FROM RAT LIVER. The Journal of Cell Biology. https://doi.org/10.1083/jcb.2.4.179
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.