The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
βIV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier
Open accessAbstract
β-Spectrin and ankyrin are major components of the membrane cytoskeleton. We have generated mice carrying a null mutation in the βIV-spectrin gene using gene trapping in embryonic stem cells. Mice homozygous for the mutation exhibit tremors and contraction of hindlimbs. βIV-spectrin expression is mostly restricted to neurons, where it colocalizes with and binds to ankyrin-G at axon initial segments (AISs) and nodes of Ranvier (NR). In βIV-spectrin–null neurons, neither ankyrin-G nor voltage-gated sodium channels (VGSC) are correctly clustered at these sites, suggesting that impaired action potential caused by mislocalization of VGSC leads to the phenotype. Conversely, in ankyrin-G–null neurons, βIV-spectrin is not localized to these sites. These results indicate that βIV-spectrin and ankyrin-G mutually stabilize the membrane protein cluster and the linked membrane cytoskeleton at AIS and NR.
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Cites
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Sodium channel Na v 1.6 is localized at nodes of Ranvier, dendrites, and synapses
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Ankyrin and spectrin associate with voltage-dependent sodium channels in brain
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Cited by
Ogiwara, I., Miyamoto, H., Morita, N., Atapour, N., Mazaki, E., Inoue, I., Takeuchi, T., Itohara, S., Yanagawa, Y., Obata, K., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5270-06.2007 · Cited by 879
Action potential generation requires a high sodium channel density in the axon initial segment
Kole, M. H. P., Ilschner, S. U., Kampa, B. M., Williams, S. R., Ruben, P. C., & Stuart, G. J. (2008) · Nature Neuroscience · doi:10.1038/nn2040 · Cited by 703
Mechanisms of axon ensheathment and myelin growth
Sherman, D. L., & Brophy, P. J. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1743 · Cited by 668
The axon initial segment and the maintenance of neuronal polarity
Rasband, M. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2852 · Cited by 442
Polarized Domains of Myelinated Axons
Salzer, J. L. (2003) · Neuron · doi:10.1016/s0896-6273(03)00628-7 · Cited by 403
Metadata
- Authors
- Komada, M., & Soriano, P.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2002-01-21
- Volume
- 156
- Issue
- 2
- Pages
- 337-348
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1978553600
- Cited by
- 289
- References
- 35
- FWCI
- 4.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Komada, M., & Soriano, P. (2002). βIV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200110003
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
