The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension
Open accessAbstract
The nonreceptor tyrosine kinase encoded by the c-Abl gene has the unique feature of an F-actin binding domain (FABD). Purified c-Abl tyrosine kinase is inhibited by F-actin, and this inhibition can be relieved through mutation of its FABD. The c-Abl kinase is activated by physiological signals that also regulate the actin cytoskeleton. We show here that c-Abl stimulated the formation of actin microspikes in fibroblasts spreading on fibronectin. This function of c-Abl is dependent on kinase activity and is not shared by c-Src tyrosine kinase. The Abl-dependent F-actin microspikes occurred under conditions where the Rho-family GTPases were inhibited. The FABD-mutated c-Abl, which is active in detached fibroblasts, stimulated F-actin microspikes independent of cell attachment. Moreover, FABD-mutated c-Abl stimulated the formation of F-actin branches in neurites of rat embryonic cortical neurons. The reciprocal regulation between F-actin and the c-Abl tyrosine kinase may provide a self-limiting mechanism in the control of actin cytoskeleton dynamics.
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Cites
Rapid Actin-Based Plasticity in Dendritic Spines
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Activation of Arp2/3 complex-mediated actin polymerization by cortactin
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BackgroundInfluentialLatrunculin alters the actin-monomer subunit interface to prevent polymerization
Morton, W. M., Ayscough, K. R., & McLaughlin, P. J. (2000) · Nature Cell Biology · doi:10.1038/35014075 · Cited by 523
Cited by
ABL Tyrosine Kinases: Evolution of Function, Regulation, and Specificity
Colicelli, J. (2010) · Science Signaling · doi:10.1126/scisignal.3139re6 · Cited by 347
Protein Kinase MARK/PAR-1 Is Required for Neurite Outgrowth and Establishment of Neuronal Polarity
Biernat, J., Wu, Y.-Z., Timm, T., Zheng-Fischhöfer, Q., Mandelkow, E., Meijer, L., & Mandelkow, E.-M. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.02-03-0046 · Cited by 279
Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation
Sini, P., Cannas, A., Koleske, A. J., Di Fiore, P. P., & Scita, G. (2004) · Nature Cell Biology · doi:10.1038/ncb1096 · Cited by 130
Activation of the neuronal c-Abl tyrosine kinase by amyloid-β-peptide and reactive oxygen species
Alvarez, A. R., Sandoval, P. C., Leal, N. R., Castro, P. U., & Kosik, K. S. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.06.007 · Cited by 125
GSK-3 Is Activated by the Tyrosine Kinase Pyk2 during LPA1-mediated Neurite Retraction
Sayas, C. L., Ariaens, A., Ponsioen, B., & Moolenaar, W. H. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0688 · Cited by 115
Metadata
- Authors
- Woodring, P. J., Litwack, E. D., O'Leary, D. D. M., Lucero, G. R., Wang, J. Y. J., & Hunter, T.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2002-02-25
- Volume
- 156
- Issue
- 5
- Pages
- 879-892
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2115491755
- Cited by
- 165
- References
- 3
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Woodring, P. J., Litwack, E. D., O'Leary, D. D. M., Lucero, G. R., Wang, J. Y. J., & Hunter, T. (2002). Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200110014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
